Cannabinoid

描述（由申请人提供）：大麻素在中枢神经系统中的功能是戈登会议，其目的是汇集对内源性和外源性大麻素的神经生物学感兴趣的知名科学家，博士后和研究生。它将每隔一年举行一次，在美国和欧洲轮流举行。下一次会议将于2007年初秋在瑞士的Les diableet举行。许多实验室正在进行的研究表明，内源性大麻素（内源性大麻素）在调节短期和长期可塑性、神经发育和神经保护方面发挥着重要作用。同时，越来越清楚的是，内源性大麻素与几种形式的行为有关，包括对常用药物的特定奖励形式。最后，大麻素的广泛娱乐性和治疗性使用对内源性大麻素信号传导效果的影响才刚刚开始得到重视。本次会议的目标是定期深入探索和整合这些关系，并确定未来几年大麻素领域最重要和最有价值的研究领域。要研究的主题包括：内源性大麻素系统的药理学探针；内源性大麻素合成与失活；大麻素受体与信号转导；大麻素与其他信号系统的相互作用；大麻素与短期和长期可塑性；大麻素和奖励：食物、性和厌恶；内源性大麻素参与神经元发育；以及长期使用大麻素后的适应性变化。

DESCRIPTION (provided by applicant): Cannabinoid function in the CNS is a Gordon Conference whose aim is to bring together established scientists, post-docs, and graduate students interested in the neurobiology of endogenous and exogenous cannabinoids. It will be held every other year, alternating between US and European sites. The next meeting, in 2007 will be held in early fall in Les Diablerets, Switzerland. Ongoing work from a number of labs suggests that endogenous cannabinoids (endocannabinoids) play a major role in regulating short and long-term plasticity, neurodevelopment, and neuroprotection. Simultaneously, it is becoming clear that endocannabinoids are involved in several forms of behavior, including specific forms of reward for commonly abused drugs. Finally, the implications of the widespread recreational and therapeutic use of cannabinoids on the efficacy of endocannabinoid signaling are just beginning to be appreciated. It is the goal of this conference to periodically explore and integrate these relationships in depth and to identify the most important and rewarding areas to be investigated in the cannabinoid field for the next several years. Examples of topics to be investigated include: Pharmacological probes of the endocannabinoid system; Endocannabinoid synthesis and inactivation; Cannabinoid receptors and signal transduction; Cannabinoid interaction with other signaling systems; Cannabinoids and short & long term plasticity; Cannabinoids and reward: food, sex, & aversion; Endocannabinoid involvement in neuronal development; and Adaptive changes following chronic cannabinoid use.