2007 Aging, Biology of Gordon Conference

2007年戈登会议的衰老、生物学

• 批准号: 7329978
• 负责人: LaDora V Thompson
• 金额: $ 5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7329978
• 关键词: Aging; Aging-Related Process; Area; Biological; Biological Models; Biology of Aging; Caenorhabditis elegans; Cell physiology; Cells; Cellular Stress; Clinical; DNA; DNA Damage; DNA Repair; Dietary Intervention; Disease; Elderly; Faculty; Funding; Funding Applicant; Future; Genetic; Goals; Health; Holly; Human; Intervention; Link; Lipids; Longevity; Maintenance; Modeling; Molecular; Molecular and Cellular Biology; Nature; Nuclear Receptors; Numbers; Organism; Physiology; Postdoctoral Fellow; Proteins; Purpose; Quality of life; Range; Research; Research Personnel; Resistance; Rodent; Science; Scientist; Stem cells; Stress; Students; Switzerland; System; Therapeutic; Tissues; Translating; Translational Research; age related; macromolecule; novel; prevent; programs; repaired; symposium

DESCRIPTION (provided by applicant): Funds are requested to provide partial support for the Gordon Research Conference (GRC) on the Biology of Aging. The theme of the 2007 conference will be "Maintenance of Macromolecular Integrity in Aging" to be held at the Les Diablerets Conference Center, Les Diablerets, Switzerland, from September 23 - 28, 2007. Drs. LaDora V. Thompson, Holly Brown-Borg and Alexander B¿rkle will organize the scientific program. Our aim here is to provide funds to support invited speakers, discussion leaders, and junior scientists (postdoctoral fellows, advanced graduate students, or new, junior faculty) who would benefit from and contribute to the conference. The speakers we have invited are internationally recognized for their research on the molecular and cellular biology of aging, physiology of aging, and genetics of aging. These speakers are known to be strong communicators of their science, who stimulate, and participate in, lively discussion. Accumulating damage of DNA has long been suggested as one of the major forms of damage that contribute to the aging process, and life spans of mammalian species positively correlate with the cellular capacity for DNA repair. But other biological macromolecules such as proteins and lipids are also known to undergo molecular damage, aggregation, and misfolding which could contribute to the aging process. Stem cells and nuclear receptors are currently being intensively investigated in their contribution to the aging process. In recent years, a large number of genetic, pharmacological and dietary interventions have been described that slow down aging in various systems ranging from unicellular organisms to humans. Many such interventions have been mechanistically linked with cellular maintenance functions and/or cellular stress resistance; they can be expected to reduce the vulnerability of cells and tissues and thus prevent age-related pathological changes. Lastly, models of accelerated aging have enhanced our understanding of cellular maintenance and stress resistance. The Gordon Research Conference will focus on these hot topics. The rationale behind the choice of these themes is the remarkable convergence of the results from the models systems to investigate cellular maintenance and integrity. The goals of the conference:-To critically assess progress in the biology of aging; To determine whether the biology of aging informs on the nature/causes of age-related decline and disease; To emphasize integrative and translational research findings as a means to develop novel future avenues for therapeutic options that extend health span. The overall purpose of the Gordon Research Conference on The Biology of Aging, "Maintenance of Macromolecular Integrity in Aging" is to bring together investigators in diverse areas of aging and investigators outside the field to discuss the current research in the field and to consider the potential to translate scientific progress into clinical interventions. The ability of cellular macromolecules (e.g., DNA, proteins, lipids) to maintain integrity, using various cellular processes (e.g. repair, degradation and replacement) and several model systems (C. elegans, rodents, fungal, accelerated aging models), is at the forefront of the biology of aging and the extension of health span. We fully anticipate that progress in this field will pave the way for interventions and quality of life for the older adult.

描述（由申请人提供）：要求资金为戈登研究会议（GRC）提供部分支持衰老生物学。2007年会议的主题是“衰老过程中大分子完整性的维持”，将于2007年9月23日至28日在瑞士的Les diableets会议中心举行。Drs。LaDora V. Thompson， Holly Brown-Borg和Alexander B¿rkle将组织这个科学项目。我们的目标是提供资金支持特邀演讲者、讨论领导者和初级科学家（博士后研究员、高级研究生或新的初级教师），他们将从会议中受益并做出贡献。我们邀请的演讲者在衰老的分子和细胞生物学、衰老生理学和衰老遗传学方面的研究是国际公认的。这些演讲者被认为是他们的科学强有力的沟通者，他们激发并参与生动的讨论。长期以来，DNA的累积损伤一直被认为是导致衰老的主要损伤形式之一，哺乳动物物种的寿命与细胞DNA修复能力呈正相关。但其他生物大分子，如蛋白质和脂质，也会经历分子损伤、聚集和错误折叠，这可能会导致衰老过程。干细胞和核受体在衰老过程中的作用目前正在被深入研究。近年来，大量的遗传、药理学和饮食干预被描述为减缓从单细胞生物到人类的各种系统的衰老。许多此类干预措施与细胞维持功能和/或细胞抗逆性有机械联系；它们可以减少细胞和组织的脆弱性，从而防止与年龄相关的病理变化。最后，加速衰老的模型增强了我们对细胞维持和抗逆性的理解。戈登研究会议将集中讨论这些热点话题。选择这些主题背后的基本原理是研究细胞维持和完整性的模型系统的结果的显著收敛。会议的目标是：-批判性地评估衰老生物学的进展；确定衰老生物学是否反映与年龄有关的衰退和疾病的性质/原因；强调综合和转化的研究成果，作为一种手段，开发新的治疗选择的未来途径，延长健康寿命。戈登衰老生物学研究会议“维持衰老中的大分子完整性”的总体目的是将衰老不同领域的研究人员和该领域以外的研究人员聚集在一起，讨论该领域的当前研究，并考虑将科学进展转化为临床干预的潜力。细胞大分子（如DNA、蛋白质、脂质）利用各种细胞过程（如修复、降解和替换）和几种模型系统（秀丽隐杆线虫、啮齿动物、真菌、加速衰老模型）维持完整性的能力，处于衰老生物学和延长健康寿命的前沿。我们充分预期，这一领域的进展将为老年人的干预措施和生活质量铺平道路。