Training Grant: Functional Proteomics of Aging

描述（由申请人提供）：我们寻求支持的跨学科培训计划在功能蛋白质组学的老化在明尼苏达大学的博士前和博士后学员。该培训计划包括两个主要部分：（1）研究培训，重点是使用蛋白质组学技术来揭示与年龄相关的组织功能丧失背后的分子细节。(2)在老年学和蛋白质组学的教学和经验培训，为学员提供一个坚实的基础，在老龄化研究成功的职业生涯。该培训计划的研究部分包括三个研究领域，重点是在衰老过程中保持生理功能：肌肉（托马斯，汤普森，劳，阿里亚加，Ervasti），中枢神经系统（奥尔森，费灵顿，低，Ervasti）和新陈代谢和长寿（Bernlohr，阿里亚加，格里芬，亨德里克森，金，低）。这些课程教师来自明尼苏达大学的两个研究生课程：生物化学，分子生物学和生物物理学（BMBB）和康复科学（RSc）。蛋白质组学分析是利用培训教师揭示改变蛋白质含量，结合伙伴，和翻译后修饰发生在老化的组织。这些信息有助于确定蛋白质结构和功能中与年龄相关的变化的机制基础。我们的研究得到了配备各种最先进的质谱仪的优秀核心的支持，如质谱和蛋白质组学中心，以及培训学院实验室的其他分析设备。培训计划还将包括通过老年学和蛋白质组学课程进行的教学培训，以及通过研讨会，研讨会，期刊俱乐部和与计划教师的小组会议进行的老龄化研究体验式培训。完成培训计划课程将使学员有资格获得老年学研究生辅修课程，从而为学员未来的职业目标提供方向。体验式培训旨在最大限度地提高学员和来自多个实验室的培训教师之间的互动。总而言之，该培训计划的主要目标是帮助杰出的年轻科学家开发作为老龄化研究中的独立调查员和教育工作者的富有成效的职业所需的知识和技术工具。

DESCRIPTION (provided by applicant): We seek support for an interdisciplinary Training Program in Functional Proteomics of Aging for both predoctoral and postdoctoral trainees at the University of Minnesota. This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component of this Training Program consists of three research areas that focus on retaining physiological function during aging: muscle (Thomas, Thompson, Lowe, Arriaga, Ervasti), the central nervous system (Olsen, Ferrington, Low, Ervasti) and metabolism and longevity (Bernlohr, Arriaga, Griffin, Hendrickson, Kim, Low). These Program Faculty members are drawn from two graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB) and Rehabilitation Sciences (RSc). Proteomic analysis is utilized by Training Faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers, such as the Center for Mass Spectrometry and Proteomics, and other analytical equipment in Training Faculty laboratories. The Training Program will also include both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via seminars, symposia, journal clubs, and group meetings with Program Faculty members. Completion of the Training Program coursework will qualify trainees for a Gerontology Graduate Minor, thus providing direction for trainees' future career goals. The experiential training is designed to maximize interaction among trainees and Training Faculty from multiple labs. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.