Academic Leadership Award - The Translational Rehabilitation in Geroscience Initiative

摘要 NIA领导力奖的长期目标是创建一个强大、高度可见、创新和 可持续的“跨学科转化性康复--以老年科学为重点的研究和教育计划” 作为波士顿大学卓越研究的基石。这包括从BASE到早期临床研究和 在高度流行的疾病特定情况下，如关节炎、中风和虚弱，情况正好相反。要完成其任务 从长远目标来看，本届领导力奖将开展三个具体目标。目标1：扩展知识 通过建立促进研究和教育的翻译康复和老年科学 一个有凝聚力的基础设施--老年科学翻译性康复倡议(TRIG倡议)。目标2： 创造一个卓越的研究和教育环境，促进成功的发展 基于老年科学的多学科翻译康复研究人员，具有定制的专业知识 临床前和临床科学。目标3：建立一个试点赠款计划，以支持最有前途的 以老年科学为重点的翻译康复研究。这些具体目标将通过 候选人对TRIG倡议的领导，打破孤岛，以及与 用于跨学科研究和教育的大量现有资源。为了支持目标1，Trig 计划将通过积极招募一个由科学家、临床医生和 波士顿学术和临床机构的受训人员以及关于翻译康复的定期讨论 研究和老年科学主题。为支持目标2，与主要利益攸关方建立跨学科伙伴关系 整个大学和波士顿社区将发展为提供丰富的研究和教育 具有翻译专业知识的学生和调查人员的职业发展机会 康复科学和老年科学(例如，研讨会、讲习班、协作实验室会议、课程)。 为了支持AIM 3，一项年度试点拨款计划将资助跨领域的多学科翻译研究 介于基础科学和早期临床科学之间。这位候选人是国际公认的肌肉专家。 生理学家，在导致石棺减少的机制方面的领先权威，并确定了老鼠的虚弱 表型评估工具，以便进行翻译研究，以梳理出脆弱的病因。这个 应聘者具有必要的科学专业知识、领导技能、临床和研究培训以及指导 和教学经验，以领导TRIG计划，实施新的活动和课程，并完成 这项提案所宣称的目标。通过NIA K07领导力奖的支持，并利用 令人印象深刻的一系列有价值的研究和教育资源，通过波士顿大学和波士顿地区，TRIG 计划设想积极的跨学科教职员工和受训人员参与合作研究、出版 和教育，建立以老年科学为基础的翻译康复研究，最终形成计划 项目资助金提交和奖励。

ABSTRACT The long-term objective of this NIA Leadership Award is to create a robust, highly visible, innovative, and sustainable “interdisciplinary translational rehabilitation Geroscience-focused research and education program” as a cornerstone of research excellence at BU. This includes both bench to early-stage clinical investigations and the reverse in highly prevalent disease-specific conditions such as arthritis, stroke, and frailty. To accomplish its long-term objective, this Leadership Award will carry out three specific aims. Aim#1: Expand the knowledge in translational rehabilitation and Geroscience by catalyzing research and education through the establishment of a cohesive infrastructure, the Translational Rehabilitation in Geroscience Initiative (TRIG Initiative). Aim#2: Create an exceptional research and educational environment that fosters development of successful multidisciplinary translational rehabilitation Geroscience-based investigators with customized expertise in preclinical and clinical science. Aim#3: Establish a pilot grant program to support the most promising translational rehabilitation Geroscience-focused studies. These specific aims will be achieved through the candidate’s leadership of the TRIG Initiative, the breaking down of silos, and the meaningful collaboration with the multitude of existing resources for interdisciplinary research and education. In support of Aim 1, the TRIG Initiative will be created through active recruitment of an interdisciplinary group of scientists, clinicians, and trainees across Boston’s academic and clinical institutions and regular discussions on translational rehabilitation research and Geroscience themes. In support of Aim 2, interdisciplinary partnerships with key stakeholders across the entire university and Boston community will be developed to offer rich research and educational opportunities for the career development of students and investigators with tailored expertise in translational rehabilitation science and Geroscience (e.g., seminars, workshops, collaborative laboratory meetings, courses.) In support of Aim 3, an annual pilot grant program will fund multidisciplinary, translational research that spans between basic and early-stage clinical sciences. The candidate is an internationally recognized muscle physiologist, a leading authority on mechanisms contributing to sarcopenia, and established the mouse frailty phenotype assessment tool in order to conduct translational research to tease out the etiology of frailty. The candidate has the necessary scientific expertise, leadership skills, clinical and research training, and mentoring and teaching experience to lead the TRIG Initiative, implement new activities and curriculum, and accomplish the stated aims of this proposal. Through the support of this NIA K07 Leadership Award and leveraging an impressive array of valuable research and educational resources through BU and the Boston area, the TRIG Initiative envisions active interdisciplinary faculty and trainees engaging in collaborative research, publications and education, building translational rehabilitation Geroscience-based research that culminates in program project grant submission and awards.