Annual Midwest DNA Repair Symposium

年度中西部 DNA 修复研讨会

• 批准号: 7264255
• 负责人: ALTAF A WANI
• 金额: $ 0.8万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7264255
• 关键词: Address; Area; Cells; Collaborations; DNA Damage; DNA Repair; DNA Repair Pathway; Diagnostic; Disease; Ensure; Fostering; Future; Genetic Materials; Genomic Instability; Genomics; Goals; Knowledge; Lesion; Life; Mind; Postdoctoral Fellow; Process; Purpose; Range; Research; Research Personnel; Scientist; Students; System; Testing; Therapeutic; Thinking; Work; Xenobiotics; base; human disease; innovation; novel strategies; peer; prevent; prognostic; repaired; symposium

DESCRIPTION (provided by applicant) Exposure of living cells to environmental xenobiotic agents produces critical structural changes in our genetic material and cause genomic instability. Living cells prevent genomic instability through elaborate repair systems which ensure the prompt reversal of genomic lesions and error-free duplication and distribution of genetic material to progeny cells. The latest discoveries in the specialized DNA repair processes provide conceptual framework for not only diagnostic and prognostic strategies but novel DNA repair driven therapeutics. Annual Midwest DNA Repair Symposium (AMDRS) provides a regular forum for deliberating a range of such discoveries in the field of basic and applied DNA repair research. The 9th AMDRS will be bringing together scientists from the U.S. Midwestern States for the goal of enhancing collaborations, and to disseminate the current state of knowledge regarding the mechanisms of DNA repair pathways and their influence on environmentally induced DNA damage and human disease. The basic objectives, guiding the conduct of this symposium, were established in 1999 at the first meeting in Ann Arbor, MI. In all subsequent meetings the theme and objectives have been carried out by subsequent symposia organizers without major deviations. The three specific aims of the AMDRS, to be continued at the 9th annual session, are: (1) to provide a venue for scientists, from principally Midwestern States, to present and discuss the current research in the field; (2) to provide students, postdoctoral fellows, and beginning independent investigators the opportunity to present their work to peers and interact with leaders in the field; and (3) to enhance interactions between researchers and foster collaborations to address important issues in the field of environmentally induced DNA damage and its impact on human disease. A congregation of innovative, creative and scientifically tested ideas and their dissemination in an intimate meeting setting is expected to allow meaningful cross-talk amongst leading area researchers for the purpose of unraveling mechanism based strategies for combating disease and establishing realistic future directions. A more important purpose served by AMDRS will be inspiring students and instigating new thoughts in fertile minds of young prot¿g¿s upon whom lies the responsibility of sustaining and advancing the field of DNA repair research.

描述（由申请人提供） 活细胞暴露于环境外源物质会导致我们的遗传物质发生关键的结构变化，并导致基因组不稳定。 活细胞通过复杂的修复系统防止基因组不稳定，确保基因组损伤的迅速逆转以及遗传物质向子代细胞的无差错复制和分配。专门 DNA 修复过程的最新发现不仅为诊断和预后策略提供了概念框架，而且为新颖的 DNA 修复驱动疗法提供了概念框架。 年度中西部 DNA 修复研讨会 (AMDRS) 提供了一个定期论坛，用于审议基础和应用 DNA 修复研究领域的一系列此类发现。 第九届 AMDRS 将汇集来自美国中西部各州的科学家，以加强合作，并传播有关 DNA 修复途径机制及其对环境引起的 DNA 损伤和人类疾病影响的最新知识。 1999 年在密歇根州安娜堡举行的第一次会议确定了指导本次研讨会开展的基本目标。 在随后的所有会议中，随后的研讨会组织者都贯彻了主题和目标，没有出现重大偏差。的三个具体目标 AMDRS 将在第九届年会上继续，其目标是：(1) 为主要来自中西部各州的科学家提供一个展示和讨论该领域当前研究的场所； (2) 提供 学生、博士后研究员和刚起步的独立研究人员有机会向同行展示他们的工作并与该领域的领导者互动； (3) 加强研究人员之间的互动并促进合作，以解决环境引起的 DNA 损伤及其对人类疾病的影响领域的重要问题。 创新、创造性和经过科学检验的想法的聚集及其在亲密会议环境中的传播预计将允许领先领域研究人员之间进行有意义的交叉对话，以阐明基于机制的抗击疾病策略并建立现实的未来方向。 AMDRS 更重要的目的是激励学生并在年轻学生的丰富思想中激发新思想，他们有责任维持和推进 DNA 修复研究领域。