Nervous System Development and Injury

描述(由申请人提供)：本申请寻求继续为华盛顿大学医学院的培训计划提供资金，该培训计划在过去24年里一直由神经科和神经外科联合管理。该基金的受训者和教职员工开展的研究主题是神经系统损伤和退化的转化性研究。申请四个名额的主要申请者是该机构成人神经病学、儿科神经病学和神经外科的医学博士或医学博士住院医师。少数博士生在教职员工的实验室进行与主题一致的研究也将被考虑，其他神经科学相关临床科室的住院医生或寻求与我们教员一起培训的其他机构的住院医生也将被考虑。37名教员由几个临床和基础科学系的资金充足的成员组成，他们中的大多数人在培养年轻科学家和内科科学家方面拥有丰富的经验。预计这笔赠款支持的受训人员将进行基于实验室和/或临床的转化性研究，为期至少两年，因为这是培养经过科学培训的神经学或神经外科临床医生所需的最低期限，科学家需要这些科学家来促进我们对这些神经性疾病的发病机制和治疗的了解。除了指导研究项目外，受训者还将根据兴趣和经验，参加个人设计的教学(课程、研讨会、期刊俱乐部)计划，以发展所需的背景、专业技术技能和沟通技能，为独立的研究生涯做准备。所有受训人员还将接受与其经验和科学兴趣相适应的研究道德行为方面的培训(例如，基于临床的研究与基于实验室的研究)。描述了选择、评估和咨询受训人员的程序。我们在寻找优秀的少数族裔参与者方面取得了相当大的成功(在过去10年中，我们有15%-20%的实习生参加了该计划)，并描述了进一步加强我们计划这方面的努力。该项目已经并将继续以华盛顿大学优秀的基础和临床神经科学的悠久传统为基础，朝着培养致力于了解和治疗这些神经系统破坏性疾病的下一代临床科学家的目标迈进。

DESCRIPTION (provided by applicant): The present application seeks continued funding for a training program at Washington University Medical School that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 24 years. The theme of the research carried out by the trainees and faculty of this grant is translational research in nervous system injury and degeneration. The primary applicant pool for the four slots requested are MD or MD/PhD residents in adult neurology, pediatric neurology, and neurosurgery at this institution. A limited number of Ph.D. candidates carrying out research consistent with the theme in the laboratories of the faculty members will also be considered, as will residents from other neuroscience-related clinical departments or residents from other institutions that seek training with our faculty. The faculty of 37 is composed of well-funded members of several clinical and basic science departments, most of whom have extensive experience in training young scientists and physician scientists. It is expected that trainees supported by this grant will carry out laboratory-based and/or clinically-based translational research for a minimum of two years as this is the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinician scientists needed to advance our understanding of the pathogenesis and treatment of these neurological disorders. In addition to the mentored research projects, trainees will participate, depending upon interests and experience, in individually designed didactic (courses, workshops, journal clubs) programs to develop needed background, specialized technical skills, and communication skills in preparation for an independent research career. All trainees will also receive training in the ethical conduct of research appropriate their experience and scientific interest (e.g., clinical- versus laboratory-based research). Procedures are described to select, evaluate, and counsel trainees. We have enjoyed reasonable success in identifying excellent minority participants in the program (15-20% of our trainees over the last 10 years) and efforts to further strengthen this aspect of our program are described. This program has, and will continue to, build upon the long tradition of excellent basic and clinical neuroscience at Washington University toward the objective of training the next generation of clinician scientists dedicated to understanding and treating these devastating disorders of the nervous system.