Nervous System Development and Injury

描述（由申请人提供）：本申请寻求继续资助华盛顿大学医学院的一个培训项目，该项目在过去24年中由神经病学和神经外科部门联合管理。该补助金的学员和教师进行的研究主题是神经系统损伤和变性的转化研究。四个申请名额的主要申请人是该机构成人神经病学，儿科神经病学和神经外科的MD或MD/PhD居民。数量有限的博士。在教师实验室进行与主题一致的研究的候选人也将被考虑，以及来自其他神经科学相关临床部门的居民或寻求与我们的教师培训的其他机构的居民。37名教师由几个临床和基础科学部门的资金充足的成员组成，其中大多数人在培训年轻科学家和医生科学家方面拥有丰富的经验。预计由该补助金支持的学员将进行至少两年的实验室和/或临床转化研究，因为这是培养经过科学培训的神经系统或神经外科临床科学家所需的最短时间，以促进我们对这些神经系统疾病的发病机制和治疗的理解。除了指导的研究项目，学员将参加，根据兴趣和经验，在单独设计的教学（课程，研讨会，期刊俱乐部）计划，以开发所需的背景，专业技术技能和沟通技巧，为独立的研究生涯做准备。所有学员还将接受与其经验和科学兴趣相适应的研究道德行为培训（例如，临床与实验室研究）。程序描述选择，评估和咨询学员。我们在确定该计划的优秀少数民族参与者方面取得了合理的成功（在过去10年中，我们的学员占15-20%），并描述了进一步加强我们计划这方面的努力。该计划已经并将继续建立在华盛顿大学优秀的基础和临床神经科学的悠久传统之上，旨在培养下一代致力于理解和治疗这些神经系统破坏性疾病的临床科学家。

DESCRIPTION (provided by applicant): The present application seeks continued funding for a training program at Washington University Medical School that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 24 years. The theme of the research carried out by the trainees and faculty of this grant is translational research in nervous system injury and degeneration. The primary applicant pool for the four slots requested are MD or MD/PhD residents in adult neurology, pediatric neurology, and neurosurgery at this institution. A limited number of Ph.D. candidates carrying out research consistent with the theme in the laboratories of the faculty members will also be considered, as will residents from other neuroscience-related clinical departments or residents from other institutions that seek training with our faculty. The faculty of 37 is composed of well-funded members of several clinical and basic science departments, most of whom have extensive experience in training young scientists and physician scientists. It is expected that trainees supported by this grant will carry out laboratory-based and/or clinically-based translational research for a minimum of two years as this is the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinician scientists needed to advance our understanding of the pathogenesis and treatment of these neurological disorders. In addition to the mentored research projects, trainees will participate, depending upon interests and experience, in individually designed didactic (courses, workshops, journal clubs) programs to develop needed background, specialized technical skills, and communication skills in preparation for an independent research career. All trainees will also receive training in the ethical conduct of research appropriate their experience and scientific interest (e.g., clinical- versus laboratory-based research). Procedures are described to select, evaluate, and counsel trainees. We have enjoyed reasonable success in identifying excellent minority participants in the program (15-20% of our trainees over the last 10 years) and efforts to further strengthen this aspect of our program are described. This program has, and will continue to, build upon the long tradition of excellent basic and clinical neuroscience at Washington University toward the objective of training the next generation of clinician scientists dedicated to understanding and treating these devastating disorders of the nervous system.