Evidence-based Principles of Treatment

NIDA确定了药物滥用者有效治疗的原则，"安德鲁斯小组" 确定了有效的康复矫正治疗原则。虽然有个别研究， 支持NIDA为药物滥用者确定的原则， 安德鲁斯组对矫正为主的治疗方法，没有进行系统综述或荟萃分析的充分研究 已进行文献研究来验证药物滥用者有效治疗的原则。前几 研究中，NDRI和ISAP的研究团队开发了两个元分析数据库， 数百项关于药物滥用者治疗的主要研究，这些数据库包含 可用于测试治疗原则中的9个的变量：13个NIDA原则中的6个， 安德鲁斯集团的三项原则。这项研究的主要目的是进行一个方法学上强有力的 这九个原则的考验。所采用的方法是系统回顾和荟萃分析现有的 NDRI和ISAP元分析数据库，扩展到包括为该项目收集的最新研究。 估计共有700项治疗有效性研究可用于荟萃分析。次级 目的是加强元分析技术，提高方法质量，方法包括：（a）确定 关于同一主题进行的荟萃分析中不一致的来源，并建议改进 协议，（B）调整和验证改进的措施的方法质量的主要研究 （c）评估处理缺失数据的不同方法的使用情况。该项目 对实践的影响，因为它将为研究人员和从业人员提供更多的知识（1） 哪些治疗原则确实有效地改善了客户的结果，可能在特定的 调节因素（例如，（2）科学的力量和局限性， 使用当前协议的荟萃分析以及如何改进这种基本方法。

NIDA has identified principles of effective treatment for substance abusers and the "Andrews Group" has identified principles of effective rehabilitative correctional treatment. Although there are individual studies to support the principles identified by NIDA for substance abusers and there are meta-analytic studies by the Andrews group on corrections-based treatment, no systematic review or meta-analysis of the full research literature has been conducted to verify principles of effective treatment for substance abusers. In previous studies, the research teams from NDRI and ISAP developed two meta-analytic databases containing hundreds of primary research studies of treatment for substance abusers, and these databases contain variables that can be used to test nine of the principles of treatment: six of the thirteen NIDA principles and all three of the Andrews group's principles. The primary aim of this study is to conduct a methodologically strong test of these nine principles. The method employed is systematic reviews and meta-analyses of the existing NDRI and ISAP meta-analytic databases, expanded to include recent studies to be collected for this project. An estimated total of 700 studies of treatment effectiveness will be available for meta-analyses. A secondary aim is to strengthen meta-analytic techniques and improve the methodological quality by (a) identifying sources of inconsistencies in meta-analyses conducted on the same topic and recommending improved protocols, (b) adapting and validating improved measures of the methodological quality of primary research studies, and (c) evaluating the use of different methods for dealing with missing data. The project has implications for practice as it will provide researchers and practitioners substantially more knowledge of (1) which principles of treatment are indeed effective in improving client outcomes, possibly under specific moderating factors (e.g., with specific types of clients), and (2) the scientific strength and limitations of meta-analysis using current protocols and how this essential method can be improved.