A High-Resolution, Large Bore MicroPET System for Translational Imaging Research

用于转化成像研究的高分辨率、大口径 MicroPET 系统

• 批准号: 7389751
• 负责人: MICHAEL DUFF DAVIS
• 金额: $ 50万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389751
• 关键词: Adult; Animal Model; Animal Organ; Animals; Arts; Basic Science; Biomedical Research; Caliber; Clinical; Clinical Research; Communities; Complement; Complex; Coupled; Cyclotrons; Development; Disease; Equipment and supply inventories; Evaluation; Foundations; Funding; Future; Human; Image; Interdisciplinary Study; Invasive; Laboratories; Ligands; Macaca mulatta; Magnetic Resonance Imaging; Malignant Neoplasms; National Center for Research Resources; Papio; Positron-Emission Tomography; Primates; Production; Radiochemistry; Research; Research Personnel; Research Proposals; Resolution; Resources; Rodent; Stroke; System; Technology; Texas; Translational Research; United States National Institutes of Health; Universities; University Hospitals; Validation; Veterans; age related; body system; catalyst; human disease; innovation; instrumentation; molecular imaging; nonhuman primate; novel; pre-clinical; radiotracer; tool

DESCRIPTION (provided by applicant): The charter of the Research Imaging Center (RIC) is to provide access to a comprehensive array of cutting- edge, non-invasive PET and MRI imaging instrumentation for prosecuting the highest quality preclinical and clinical research. With this proposal, funds are sought to expand the existing small-animal PET laboratory by adding a new, state-of-the-art Siemens Focus 220 microPET system. In the past, numerous investigators wielding attractive research proposals were turned away for practical considerations; because either their subjects were too large to fit in the RIC's older rodent PET, or the resolution of this unit, and that of our clinical PET scanners, lack sufficient resolving power. The advanced features of the Focus 220 include superior resolution; nearly double that of any other human or large animal PET camera in production, and a wider field of view. With twice the bore diameter of the rodent PET, the Focus 220 aperture will now permit studies using much larger subjects, including adult non-human primates such as rhesus and baboons. In timely complement to this PET system will be the RIC's new cyclotron and radiochemistry complex, expected to be commissioned in spring 2007. This $5.2M facility was successfully funded through a campaign of private philanthropy and a special allocation from the University of Texas System; a demonstration of the continuing commitment to develop the RIC as a formidable regional resource in translational research. Cyclotron-generated radiotracer development and validation would be accelerated with the Focus 220 using animal models. The prospect of acquiring a high-resolution, wide-bore microPET, coupled with access to a diverse inventory of classical and novel PET ligands for molecular imaging, was the catalyst in generating the 34 interdisciplinary research proposals described herein from the RIC's current and future collaborators. This is a testament to the potential impact the Focus 220 would bring in serving a multi-disciplinary, cross-institutional scientific community that includes UTHSCSA, the Southwest Foundation for Biomedical Research (SFBR), the Audie Murphy Veterans Hospital and the University of Texas. Another strategic asset is the RIC's interactive partnership with the nearby NCRR Southwest National Primate Research Center (SNPRC), where an eclectic colony of non-human primates is maintained. This affords an exceptional opportunity for those wishing to use subjects that are more phylogenetically related to humans. Acquisition of the Focus 220 system will provide a powerful new tool that will drive high-caliber, high-impact translatable research and serve to spawn future innovative NIH proposals. Steady advances in basic science have yielded valuable animal models of human disease, just as improvements in technology have given us increasingly more powerful research tools with which to study them. This PET system will enhance our ability to non-invasively and non-destructively image animal organ systems for biomedical research and accelerate the evaluation of emerging therapies for treating human disorders, such as cancer, stroke and aging-related diseases.

描述（由申请人提供）：研究成像中心（RIC）的章程旨在提供一系列尖端、非侵入性PET和MRI成像仪器，以进行最高质量的临床前和临床研究。通过该提案，寻求资金通过添加新的最先进的西门子Focus 220 microPET系统来扩大现有的小动物PET实验室。在过去，许多研究人员挥舞着有吸引力的研究建议被拒绝的实际考虑;因为他们的主题太大，以适应在RIC的旧啮齿动物PET，或该单位的分辨率，我们的临床PET扫描仪，缺乏足够的分辨率。Focus 220的先进功能包括上级分辨率;几乎是生产中任何其他人类或大型动物PET相机的两倍，以及更宽的视野。Focus 220的孔径是啮齿动物PET的两倍，现在可以使用更大的受试者进行研究，包括成年非人类灵长类动物，如恒河猴和狒狒。在及时补充这一PET系统将是RIC的新的回旋加速器和放射化学复合体，预计将在2007年春季投产。这个520万美元的设施是通过私人慈善活动和德克萨斯大学系统的特别拨款成功资助的;这表明了将RIC发展为转化研究领域强大的区域资源的持续承诺。使用动物模型，使用Focus 220加速回旋加速器产生的放射性示踪剂的开发和验证。获得高分辨率，宽口径microPET的前景，再加上获得用于分子成像的经典和新型PET配体的多样化库存，是RIC当前和未来合作者产生本文所述的34个跨学科研究提案的催化剂。这证明了Focus 220将为包括UTHSCSA，西南生物医学研究基金会（SFBR），Audie Murphy退伍军人医院和德克萨斯大学在内的多学科，跨机构科学界带来的潜在影响。另一个战略资产是RIC与附近的NCRR西南国家灵长类动物研究中心（SNPRC）的互动伙伴关系，在那里维持着一个非人类灵长类动物的折衷殖民地。这为那些希望使用与人类遗传学更相关的受试者提供了一个特殊的机会。收购Focus 220系统将提供一个强大的新工具，推动高质量、高影响力的可翻译研究，并有助于催生未来的创新NIH提案。基础科学的稳步发展已经产生了有价值的人类疾病动物模型，正如技术的进步为我们提供了越来越强大的研究工具来研究它们一样。该PET系统将增强我们对动物器官系统进行非侵入性和非破坏性成像的能力，用于生物医学研究，并加速评估用于治疗人类疾病的新兴疗法，如癌症，中风和衰老相关疾病。