Thermo Finnigan LTQ-Orbitrap

Thermo Finnigan LTQ-Orbitrap

• 批准号: 7214610
• 负责人: JULIE Ann LEARY
• 金额: $ 49.9万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-15 至 2008-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214610
• 关键词: California; Communities; Consultations; Data; Electrons; Funding; Genome; Mass Spectrum Analysis; Measurement; Proteomics; Research; Research Personnel; Resolution; Running; Sampling; Students; System; Training; Universities; Week; Work; base; day; instrument; mass spectrometer; professor; small molecule

DESCRIPTION (provided by applicant): The University of California at Davis seeks funding for an accurate mass, high resolution mass spectrometer. The Thermo Electron Orbitrap instrument has been identified as the best instrument for the campus Satellite Mass Spectrometry Facilities (CSMSF). The two satellite Facilities, which comprise the CSMSF, are available 24hrs/day, 7 days/week to campus researchers. Currently there are no high resolution mass spectrometers on the Davis campus for small molecule analysis. There are several PI owned high resolution instruments (FTICR) however, these are not available to the general research community on campus. An FT in the Genome center is used exclusively for proteomics. The Orbitrap can be easily integrated into the existing CSMSF which is composed of three other instruments all of which are operated on a 24/7 basis. This open access system has worked remarkably well and the Orbitrap would finally bring high resolution mass measurements to the general scientific campus community. Demonstration samples run on the Orbitrap (see data in proposal) have shown it to be very reliable, very accurate and easily operated by graduate students and postdoctoral associates. The lack of cryogens makes this instrument particularly attractive and will serve as a robust high resolution, student operated instrument. A mechanism is in place to train and oversee student researchers and Professor Leary's group is available for consultation, advice and data interpretation.

描述（由申请人提供）：加州大学戴维斯分校为一个精确质量、高分辨率质谱仪寻求资助。热电子轨道阱仪器已被确定为校园卫星质谱设施（CSMSF）的最佳仪器。这两个卫星设施组成了CSMSF，每周7天，每天24小时为校园研究人员提供服务。目前，戴维斯校区没有用于小分子分析的高分辨率质谱仪。有几个PI拥有的高分辨率仪器（FTICR），然而，这些是不可用的一般研究社区在校园。基因组中心的FT专门用于蛋白质组学。Orbitrap可以很容易地集成到现有的CSMSF中，CSMSF由其他三个仪器组成，这些仪器都是全天候运行的。这个开放访问系统运行得非常好，Orbitrap最终将为一般的科学校园社区带来高分辨率的质量测量。在Orbitrap上运行的演示样本（见提案中的数据）表明，它非常可靠，非常准确，并且易于研究生和博士后同事操作。由于缺乏冷冻装置，这款仪器特别具有吸引力，将成为一款强大的高分辨率、学生操作的仪器。一个培训和监督学生研究人员的机制已经到位，Leary教授的小组可以提供咨询、建议和数据解释。