TERRY BEIRN COMMUNITY PROGRAMS FOR CLINICAL RESEARCH ON

艾滋病临床研究社区项目（CPCRA）是一个以社区为基础的临床试验小组，它建议包括美国的19个单位以及澳大利亚、加拿大和英国的临床站点。这是统计和数据管理中心（SDMC）对该试验组的建议。SDMC对随附的核心提案中概述的科学议程的统计部分负有主要责任。SDMC还主要负责制定数据收集、管理和报告程序，以确保研究得到适当实施和监测。目标分为四个广泛而相互关联的领域：1)通过合作制定综合科学议程、在研究设计中采用创新方法、进行中期和最后分析以及举办研究方法研讨会，为小组提供统计领导；2)继续完善系统，以便及时有效地收集、处理和报告数据，以达到研究目标；3)与澳大利亚、加拿大和英国的国家试验协调中心合作，协助随机化程序、数据管理和数据分析，并与其他临床试验组就特定研究进行合作；4)与CPCRA的所有组织小组和委员会密切合作，以执行科学议程，并保持SDMC的组织结构和人员与更大的CPCRA组织保持一致，并提供激励的工作氛围和同伴支持。

The Community Programs for Clinical Research on AIDS (CPCRA) is a community-based clinical trials group which proposes to include 19 units in the United States and clinical sites in Australia, Canada, and the United Kingdom. This is a proposal for the Statistical and Data Management Center (SDMC) for this trials group. The SDMC bears primary responsibility for the statistical components of the science agenda outlined in the accompanying core proposal. The SDMC also has primary responsibility for the development of data collection, management, and reporting procedures that ensure that the studies are properly implemented and monitored. Objectives fall into four broad and interrelated areas: l) to provide statistical leadership to the group by collaborating on the development of an integrated scientific agenda, by using innovative approaches in the design of studies, by carrying out interim and final analyses, and by conducting seminars on research methods; 2) to continue to enhance systems for collecting, processing and reporting data in a timely and efficient way so that study objectives are met; 3) to collaborate with national trial coordinating centers in Australia, Canada, and the United Kingdom which will assist with randomization procedures, data management, and data analysis, and to collaborate with other clinical trial groups on specific studies; and 4) to work closely with all of the organizational groups and committees in the CPCRA to carry out the scientific agenda, and to maintain a SDMC organizational structure and staff that aligns with the larger CPCRA organization and provides a stimulating work atmosphere and peer support.