Ophthalmic Imaging Using Adaptive Optics and OCT

使用自适应光学和 OCT 进行眼科成像

• 批准号: 7118940
• 负责人: JOHN S WERNER
• 金额: $ 101.29万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118940
• 关键词: aging; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; cell morphology; clinical biomedical equipment; clinical research; computer human interaction; cone cell; cooperative study; density; eye disorder diagnosis; glaucoma; glaucoma test; human subject; image enhancement; light scattering; macular degeneration; optical tomography; patient oriented research; retinal ganglion; retinal pigment epithelium; rod cell; three dimensional imaging /topography; visual perception

DESCRIPTION (provided by applicant): The purpose of this BRP is to develop and evaluate new instrumentation that will permit unprecedented three dimensional imaging of single cells in the human retina, specifically rod and cone photoreceptors and ganglion cells. An interdisciplinary team will combine adaptive optics (AO), enabling the best lateral resolution for retinal imaging, with optical coherence tomography (OCT), providing the best axial resolution for retinal imaging. Two instruments will be developed using complementary OCT imaging modalities, flood illumination and enface scanning. These instruments will be used to study cellular morphology associated with normal aging, age-related macular degeneration (AMD) and glaucoma. The instruments will be compared quantitatively with each other and with existing retinal imaging devices. The project will be led by UC-Davis COCD), where a high-performance AO system has been developed in collaboration with the Lawrence Livermore National Laboratory (LLNL). This collaboration will be expanded to include a team of OCT experts at LLNL and Indiana University (IU). The IU team has previously collaborated with LLNL through the Center for Adaptive Optics and has already developed a working prototype AO-OCT system for retinal imaging. In this BRP project, LLNL will construct one AO-OCT instrument at the UCD site to be tested clinically in years 3-5, while the second AO-OCT instrument will be developed at IU in collaboration with LLNL and tested in the laboratory in years 4-5. Comparisons of AO-OCT and functional measures will be obtained at UCD and IU. Both instruments will be made available for use by scientists and clinicians who are not part of the BRP, and will be refined through the course of the project period. UCD has expertise in vision science, aging, and evaluation of AMD and glaucoma progression and treatment LLNL has a long history of research on AO for astronomy and has transferred some of its AO technology to vision science at UCD. LLNL also has expertise in OCT, and has pioneered its application to in vivo imaging of oral and vascular structures. The IU team has experience in AO-OCT and vision science with specific expertise in visual optics and retinal electrophysiology. This BRP is buttressed by consultants who have developed ophthalmic OCT technology at the University of Texas and Carl Zeiss Meditec. The Zeiss group has already transferred OCT technology to the clinic via commercial development and will facilitate incorporation of user friendly interfaces for our AO-OCT systems. This BRP thus combines the unique expertise of engineers, vision scientists and clinicians who have experience working together to effect a smooth transition from the laboratory to applications. This synergistic team will develop a new generation of instruments to advance vision science, permit retinal dysfunction to be studied in vivo in a way that will offer new insights into normal aging, the pathogenesis of glaucoma and macular degeneration, and a reliable method to monitor novel treatments for retinal disease.

描述（由申请人提供）： 本BRP的目的是开发和评估新的仪器，将允许前所未有的三维成像的单细胞在人类视网膜，特别是杆和锥光感受器和神经节细胞。一个跨学科的团队将把联合收割机自适应光学（AO）与光学相干断层扫描（OCT）结合起来，前者为视网膜成像提供最佳的横向分辨率，后者为视网膜成像提供最佳的轴向分辨率。将使用互补的OCT成像模式（泛光照明和表面扫描）开发两种仪器。这些仪器将用于研究与正常衰老、年龄相关性黄斑变性（AMD）和青光眼相关的细胞形态。这些仪器将相互进行定量比较，并与现有的视网膜成像设备进行比较。该项目将由加州大学戴维斯分校（UC-Davis COCD）领导，该项目与劳伦斯利弗莫尔国家实验室（LLNL）合作开发了一种高性能AO系统。这种合作将扩大到包括LLNL和印第安纳州大学（IU）的OCT专家团队。IU团队此前曾通过自适应光学中心与LLNL合作，并已开发出用于视网膜成像的工作原型AO-OCT系统。在这个BRP项目中，LLNL将在UCD现场建造一台AO-OCT仪器，在第3-5年进行临床测试，而第二台AO-OCT仪器将在IU与LLNL合作开发，并在第4-5年在实验室进行测试。将在UCD和IU获得AO-OCT和功能测量的比较。这两种工具将提供给不属于BRP的科学家和临床医生使用，并将在项目期间进行完善。UCD在视觉科学，衰老和评估AMD和青光眼进展和治疗方面具有专业知识LLNL在天文学的AO研究方面有着悠久的历史，并将其一些AO技术转移到UCD的视觉科学。LLNL还拥有OCT方面的专业知识，并率先将其应用于口腔和血管结构的体内成像。IU团队在AO-OCT和视觉科学方面拥有丰富的经验，并在视觉光学和视网膜电生理学方面拥有特定的专业知识。该BRP得到了德克萨斯大学和Carl Zeiss Meditec开发眼科OCT技术的顾问的支持。蔡司集团已经通过商业开发将OCT技术转移到临床，并将促进我们的AO-OCT系统的用户友好界面的整合。因此，该BRP结合了工程师，视觉科学家和临床医生的独特专业知识，他们具有共同工作的经验，以实现从实验室到应用的平稳过渡。该协同团队将开发新一代仪器，以推进视觉科学，允许在体内研究视网膜功能障碍，为正常衰老，青光眼和黄斑变性的发病机制提供新的见解，并提供可靠的方法来监测视网膜疾病的新治疗方法。