Structure and Function of the Chorioretinal Complex in Age-Related Macular Degene
年龄相关性黄斑变性中脉络膜视网膜复合体的结构和功能
基本信息
- 批准号:9247197
- 负责人:
- 金额:$ 47.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-04-01 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAge related macular degenerationAlgorithmsAngiographyAreaAtrophicBiological AgingBlindnessBlood VesselsBlood flowBruch&aposs basal membrane structureCell physiologyCharacteristicsChoroidChoroidal NeovascularizationComplexConeDependenceDetectionDevelopmentDiseaseDrusenEarly DiagnosisEvaluationExudative age-related macular degenerationEyeEye diseasesFluoresceinFunctional disorderFundusFutureGenerationsGoalsHealthHourHumanImageImaging technologyImpairmentIndocyanine GreenInjection of therapeutic agentKnowledgeLasersLateralLengthLightLocalized DiseaseLocationMapsMeasuresMethodsModalityMorphologyNonexudative age-related macular degenerationOphthalmoscopyOptical Coherence TomographyOpticsPathogenesisPatientsPenetrationPerfusionPhagocytosisPhasePhotoreceptorsPsychophysicsResearchResolutionRetinaRetinalRetinal ConeRetinal DiseasesRetrievalRhodopsinScanningSchemeSecondary toSourceSpeedStructureStructure of retinal pigment epitheliumSystemTechnologyTestingThickTimeTreatment FactorUrsidae FamilyVascular Endothelial Growth FactorsVascularizationWorkadaptive opticsadaptive optics scanning laser ophthalmoscopyage relatedbasedensityeffective therapygeographic atrophyhuman diseaseimage processingin vivoin vivo imagingindexinginhibitor/antagonistmaculamicroscopic imagingnoveloptical imagingphase changeprogramspublic health relevanceretinal rodsscreeningtherapy designtool
项目摘要
DESCRIPTION (provided by applicant): Three aims are proposed to study the chorioretinal complex (choroid, choriocapillaris, Bruch's membrane, retinal pigment epithelium, photoreceptors) in age-related macular degeneration (AMD). Each aim includes both technical goals involving optical imaging and tests of hypotheses related to the pathogenesis of this disease. Aim 1 will use phase changes between successive optical coherence tomography (OCT) B-scans (frames) to visualize the vascular layers behind the retina, specifically the choriocapillaris, Sattler's and Haller's layers of the choroid. Use of a 1050 nm light source will provide deep penetration through the retinal pigment epithelium to study changes in vascularization associated with nonexudative AMD, a condition for which there is currently no effective treatment. It will also permit in vivo examination of changes in subretinal vascularization associated with anti-VEGF treatment for neovascular AMD, a treatment that is generally effective but not completely understood. Aim 2 will measure fundus autofluorescence (FAF) and morphology of the retinal pigment epithelium in geographic atrophy using ultrahigh-resolution adaptive optics (AO) with simultaneous reflectance and fluorescent scanning laser ophthalmoscopy and OCT volumetric imaging to co- localize disease-related changes visualized with the two modalities. This aim will investigate the hypothesis that some of the changes in FAF characterizing AMD are secondary to changes in rhodopsin photopigment screening of the excitation and emitted light. This result may alter interpretations of FAF changes in AMD and other diseases of the chorioretinal complex associated with rod photoreceptor losses, and will be critical in developing or assessing new treatments. Aim 3 will use a newly constructed afocal AO-OCT system and phase retrieval algorithm to measure changes in length and renewal rates of the photoreceptor outer segments in normal retinae and those with drusen characteristic of early and intermediate stage AMD. Changes in photoreceptors will be characterized over short- and long-term time scales. These results may provide new and sensitive functional indicators of AMD progression and a leading indicator of changes in the health of the chorioretinal complex at the intersection between biological aging and eye disease.
描述(申请人提供):提出三个目标来研究年龄相关性黄斑变性(AMD)的脉络膜视网膜复合体(脉络膜、脉络膜毛细血管、Bruchs膜、视网膜色素上皮、光感受器)。每个目标都包括涉及光学成像的技术目标和与这种疾病的发病机制相关的假说的测试。目标1将使用连续光学相干断层扫描(OCT)B扫描(帧)之间的相位变化来可视化视网膜后面的血管层,特别是脉络膜的脉络膜毛细血管、Sattler‘s和Haller’s层。使用1050 nm光源将提供对视网膜色素上皮的深度穿透,以研究与非渗出性AMD相关的血管形成的变化,目前尚无有效的治疗方法。它还将允许体内检查与抗血管内皮生长因子治疗新生血管性AMD相关的视网膜下血管的变化,这是一种通常有效但尚未完全了解的治疗方法。目的2利用同步反射的超高分辨率自适应光学(AO)和荧光扫描激光眼底镜及OCT体积成像技术,测量地理性萎缩患者的眼底自发荧光(Faf)和视网膜色素上皮的形态,以共同定位两种模式所显示的疾病相关变化。这一目的将调查这样一种假设,即表征AMD的Faf的一些变化是继发于激发和发射光的视紫红质光色素屏蔽的变化。这一结果可能改变对AMD和其他与视杆感光细胞丧失相关的脉络膜视网膜复合体疾病的Faf变化的解释,并将对开发或评估新的治疗方法至关重要。目的3将利用新建立的无焦AO-OCT系统和相位恢复算法来测量正常视网膜和早、中期AMD玻璃体特征患者的光感受器外段的长度和更新率的变化。光感受器的变化将在短期和长期的时间尺度上进行表征。这些结果可能提供AMD进展的新的和敏感的功能指标,以及生物衰老和眼病交界处的脉络膜视网膜复合体健康变化的领先指标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN S WERNER其他文献
JOHN S WERNER的其他文献
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{{ truncateString('JOHN S WERNER', 18)}}的其他基金
Structure and Function of the Chorioretinal Complex in Age-Related Macular Degene
年龄相关性黄斑变性中脉络膜视网膜复合体的结构和功能
- 批准号:
8665661 - 财政年份:2014
- 资助金额:
$ 47.24万 - 项目类别:
Structure and Function of the Chorioretinal Complex in Age-Related Macular Degene
年龄相关性黄斑变性中脉络膜视网膜复合体的结构和功能
- 批准号:
8827354 - 财政年份:2014
- 资助金额:
$ 47.24万 - 项目类别:
Structure and Function of the Chorioretinal Complex in Age-Related Macular Degene
年龄相关性黄斑变性中脉络膜视网膜复合体的结构和功能
- 批准号:
9034586 - 财政年份:2014
- 资助金额:
$ 47.24万 - 项目类别:
NIAR01AG004058 Research Supplements to Promote Diversity in Health-Related Research
NIAR01AG004058 促进健康相关研究多样性的研究补充剂
- 批准号:
8855231 - 财政年份:2014
- 资助金额:
$ 47.24万 - 项目类别:
Ophthalmic Imaging Using Adaptive Optics and OCT
使用自适应光学和 OCT 进行眼科成像
- 批准号:
8132335 - 财政年份:2003
- 资助金额:
$ 47.24万 - 项目类别:
Ophthalmic Imaging Using Adaptive Optics and OCT
使用自适应光学和 OCT 进行眼科成像
- 批准号:
8539869 - 财政年份:2003
- 资助金额:
$ 47.24万 - 项目类别:
Ophthalmic Imaging Using Adaptive Optics and OCT
使用自适应光学和 OCT 进行眼科成像
- 批准号:
7118940 - 财政年份:2003
- 资助金额:
$ 47.24万 - 项目类别:
Ophthalmic Imaging Using Adaptive Optics and OCT
使用自适应光学和 OCT 进行眼科成像
- 批准号:
8326723 - 财政年份:2003
- 资助金额:
$ 47.24万 - 项目类别:
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