The Rutgers Mapping Resources

罗格斯大学测绘资源

• 批准号: 7234626
• 负责人: TARA C. MATISE
• 金额: $ 10.78万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-10 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234626
• 关键词: Animals; Base Sequence; Canis familiaris; Chromosome Mapping; Collection; Commit; Communities; Computer software; Computers; Count; Custom; Data; Development; Documentation; Ensure; Facility Construction Funding Category; Genes; Genetic; Genetic Research; Genome; Genomics; Health; Hereditary Disease; Human; Human Genetics; Inherited; Instruction; International; Internet; Letters; Localized Disease; Mails; Maintenance; Maps; Meiotic Recombination; Methods; Mus; Numbers; Online Systems; Organism; Physical Map of the Human Genome; Plants; Play; Polymorphic Microsatellite Marker; Procedures; Protocols documentation; Publications; Radiation Hybrid Map; Radiation Hybrid Mapping; Rattus; Research Personnel; Resources; Role; Site; Update; base; computer program; design; evaluation/testing; genotyping technology; improved; interest; novel; physical mapping; programs; response

DESCRIPTION (provided by applicant): Genetic linkage maps continue to play a critical role for gene mapping studies in humans and other organisms. Radiation hybrid maps are also playing an important role in the genome projects of several animal species. The Rutgers Mapping Resources are a unique collection of software programs, maps, and web applications designed to facilitate the construction and dissemination of several types of genomic maps. The Rutgers Mapping Resources include the MultiMap/CRIMAP program, the Rutgers Gombined Linkage- Physical Map, and the MAP-O-MAT web-based mapping server. MultiMap automates and facilitates the construction of linkage and radiation hybrid maps. The Rutgers Combined Linkage-Physical Map is the most comprehensive linkage map available to date, and is novel in that it incorporates both meiotic recombination map data as well as sequence-based positional information. MAP-O-MAT is a web-based server with data and applications for automated linkage mapping of human polymorphic markers, and is our mechanism for dissemination of the Rutgers Maps. These resources have served, and continue to serve, an important role in the international genetics research community, for studies in humans as well as other species. The basis for this claim comes from the numerous citations of our resource publications, many strong letters of support from current users, tallies of hits to our WWW/FTP sites, and the frequent and varying e-mail inquiries we receive. The Rutgers Mapping Resources have been used to help localize disease genes for many inherited genetic disorders with significant health impact. Under this proposal we will continue to develop these important resources in order to enhance and maintain their utility for investigators studying humans and other species. In particular, we propose to implement an interpolation method for placing physically-mapped markers onto our combined linkage-physical map, a feature which has growing importance as high-throughput genotyping technologies continue to advance. We will apply our combined-mapping procedure to data from the genome projects of non-human species such as mouse, rat, dog, and others. We will improve our MAP-O-MAT web server and develop a stand-alone shareable version. We will enhance our documentation, online help, and create useful new tutorials for all of our resources. We will also improve our resource integration and continue to maintain these resources while providing excellent user support. We remain fully committed to keeping all of our software and resources freely available. Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software."

描述（由申请人提供）：遗传连锁图谱在人类和其他生物体的基因图谱研究中继续发挥着关键作用。辐射杂交图谱在几种动物物种的基因组计划中也发挥着重要作用。罗格斯大学绘图资源是软件程序、地图和网络应用程序的独特集合，旨在促进多种类型的基因组图谱的构建和传播。罗格斯地图资源包括 MultiMap/CRIMAP 程序、罗格斯 Gombined Linkage-Physical Map 和 MAP-O-MAT 基于 Web 的地图服务器。 MultiMap 可自动化并促进联动和辐射混合地图的构建。罗格斯大学联合连锁物理图谱是迄今为止最全面的连锁图谱，其新颖之处在于它结合了减数分裂重组图谱数据以及基于序列的位置信息。 MAP-O-MAT 是一个基于网络的服务器，包含用于人类多态性标记自动连锁图谱的数据和应用程序，也是我们传播罗格斯图谱的机制。这些资源已经并将继续在国际遗传学研究界、人类和其他物种的研究中发挥重要作用。这一主张的基础来自于对我们资源出版物的大量引用、来自当前用户的许多强有力的支持信、我们 WWW/FTP 站点的点击量统计以及我们收到的频繁且不同的电子邮件查询。罗格斯大学绘图资源已被用来帮助定位许多对健康产生重大影响的遗传性疾病的疾病基因。根据这项提案，我们将继续开发这些重要资源，以增强和维持它们对研究人类和其他物种的研究人员的效用。特别是，我们建议实施一种插值方法，将物理作图标记放置到我们的组合连锁物理图上，随着高通量基因分型技术的不断进步，这一功能变得越来越重要。我们将把我们的组合作图程序应用于来自非人类物种（例如小鼠、大鼠、狗等）的基因组项目的数据。我们将改进 MAP-O-MAT 网络服务器并开发独立的可共享版本。我们将增强我们的文档、在线帮助，并为我们的所有资源创建有用的新教程。我们还将完善我们的资源整合，并继续维护这些资源，同时提供优秀的用户支持。我们仍然完全致力于免费提供我们的所有软件和资源。我们的提案是根据 PAR-05-057“软件的持续开发和维护”提交的，旨在“支持现有软件的持续开发、维护、测试和评估”。