The Rutgers Mapping Resources

描述(由申请人提供)：遗传连锁图谱继续在人类和其他生物的基因图谱研究中发挥关键作用。辐射杂交图谱也在几个动物物种的基因组计划中发挥着重要作用。罗格斯图谱资源是一个独特的软件程序、地图和网络应用程序的集合，旨在促进几种类型基因组图谱的构建和传播。罗格斯地图资源包括多地图/CRIMAP程序、罗格斯综合链接-物理地图和MAP-O-MAT网络地图服务器。多地图使链接和辐射混合地图的构建自动化和便利化。罗格斯连锁-物理图谱是迄今为止可用的最全面的连锁图谱，其新颖之处在于它结合了减数分裂重组图谱数据和基于序列的位置信息。MAP-O-MAT是一个基于网络的服务器，包含用于人类多态标记的自动连锁作图的数据和应用程序，也是我们传播罗格斯地图的机制。这些资源在国际遗传学研究界为人类和其他物种的研究发挥了重要作用，并将继续发挥作用。这一说法的依据来自我们资源出版物的大量引用、当前用户的许多强烈支持信、对我们WWW/FTP站点的点击量统计，以及我们收到的频繁而多样的电子邮件查询。罗格斯图谱资源已被用于帮助定位许多对健康有重大影响的遗传性遗传性疾病的疾病基因。根据这项提议，我们将继续开发这些重要资源，以增强和保持它们对研究人类和其他物种的调查人员的效用。特别是，我们建议实现一种内插方法，将物理映射的标记放置到我们的组合连锁-物理图谱上，随着高通量基因分型技术的不断进步，这一功能具有越来越重要的意义。我们将把我们的组合作图程序应用于非人类物种的基因组项目中的数据，如小鼠、大鼠、狗和其他物种。我们将改进我们的MAP-O-MAT网络服务器，并开发一个独立的可共享版本。我们将增强我们的文档、在线帮助，并为我们所有的资源创建有用的新教程。我们还将完善我们的资源整合，并在提供出色用户支持的同时继续维护这些资源。我们仍然完全致力于保持我们所有的软件和资源免费可用。我们的提案是根据PAR-05-057“软件的持续开发和维护”提交的，旨在“支持现有软件的持续开发、维护、测试和评估”。

DESCRIPTION (provided by applicant): Genetic linkage maps continue to play a critical role for gene mapping studies in humans and other organisms. Radiation hybrid maps are also playing an important role in the genome projects of several animal species. The Rutgers Mapping Resources are a unique collection of software programs, maps, and web applications designed to facilitate the construction and dissemination of several types of genomic maps. The Rutgers Mapping Resources include the MultiMap/CRIMAP program, the Rutgers Gombined Linkage- Physical Map, and the MAP-O-MAT web-based mapping server. MultiMap automates and facilitates the construction of linkage and radiation hybrid maps. The Rutgers Combined Linkage-Physical Map is the most comprehensive linkage map available to date, and is novel in that it incorporates both meiotic recombination map data as well as sequence-based positional information. MAP-O-MAT is a web-based server with data and applications for automated linkage mapping of human polymorphic markers, and is our mechanism for dissemination of the Rutgers Maps. These resources have served, and continue to serve, an important role in the international genetics research community, for studies in humans as well as other species. The basis for this claim comes from the numerous citations of our resource publications, many strong letters of support from current users, tallies of hits to our WWW/FTP sites, and the frequent and varying e-mail inquiries we receive. The Rutgers Mapping Resources have been used to help localize disease genes for many inherited genetic disorders with significant health impact. Under this proposal we will continue to develop these important resources in order to enhance and maintain their utility for investigators studying humans and other species. In particular, we propose to implement an interpolation method for placing physically-mapped markers onto our combined linkage-physical map, a feature which has growing importance as high-throughput genotyping technologies continue to advance. We will apply our combined-mapping procedure to data from the genome projects of non-human species such as mouse, rat, dog, and others. We will improve our MAP-O-MAT web server and develop a stand-alone shareable version. We will enhance our documentation, online help, and create useful new tutorials for all of our resources. We will also improve our resource integration and continue to maintain these resources while providing excellent user support. We remain fully committed to keeping all of our software and resources freely available. Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software."