The Rutgers Mapping Resources

描述（由申请人提供）：遗传连锁图谱继续在人类和其他生物的基因定位研究中发挥关键作用。辐射杂交图谱在一些动物物种的基因组计划中也发挥着重要作用。罗格斯测绘资源是一个独特的软件程序、地图和网络应用程序的集合，旨在促进几种基因组图谱的构建和传播。罗格斯大学地图资源包括MultiMap/CRIMAP程序、罗格斯大学联合链接-物理地图和基于web的Map - o - mat地图服务器。MultiMap自动化并简化了链接和辐射混合地图的构建。罗格斯联合链接-物理图谱是迄今为止最全面的链接图谱，其新颖之处在于它结合了减数分裂重组图谱数据和基于序列的位置信息。MAP-O-MAT是一个基于web的服务器，包含用于人类多态标记自动链接映射的数据和应用程序，是我们传播罗格斯地图的机制。这些资源已经并将继续在国际遗传学研究界为人类和其他物种的研究发挥重要作用。这种说法的基础来自于对我们的资源出版物的大量引用，来自当前用户的许多强有力的支持信，对我们的WWW/FTP站点的点击记录，以及我们收到的频繁和不同的电子邮件查询。罗格斯测绘资源已被用于帮助定位许多具有重大健康影响的遗传性遗传病的疾病基因。根据这项提议，我们将继续开发这些重要的资源，以提高和保持它们对研究人类和其他物种的研究人员的效用。特别是，我们建议实现一种插值方法，将物理映射的标记放置到我们的联合链接-物理图谱上，随着高通量基因分型技术的不断发展，这一特征变得越来越重要。我们将把我们的组合制图程序应用于非人类物种的基因组计划数据，如小鼠、大鼠、狗和其他物种。我们将改进我们的MAP-O-MAT web服务器，并开发一个独立的可共享版本。我们将增强我们的文档、在线帮助，并为我们所有的资源创建有用的新教程。我们还将改进我们的资源整合，并在提供优秀用户支持的同时继续维护这些资源。我们仍然完全致力于保持我们所有的软件和资源免费提供。我们的提案是根据PAR-05-057“软件的持续开发和维护”提交的，其目的是“支持现有软件的持续开发、维护、测试和评估”。

DESCRIPTION (provided by applicant): Genetic linkage maps continue to play a critical role for gene mapping studies in humans and other organisms. Radiation hybrid maps are also playing an important role in the genome projects of several animal species. The Rutgers Mapping Resources are a unique collection of software programs, maps, and web applications designed to facilitate the construction and dissemination of several types of genomic maps. The Rutgers Mapping Resources include the MultiMap/CRIMAP program, the Rutgers Gombined Linkage- Physical Map, and the MAP-O-MAT web-based mapping server. MultiMap automates and facilitates the construction of linkage and radiation hybrid maps. The Rutgers Combined Linkage-Physical Map is the most comprehensive linkage map available to date, and is novel in that it incorporates both meiotic recombination map data as well as sequence-based positional information. MAP-O-MAT is a web-based server with data and applications for automated linkage mapping of human polymorphic markers, and is our mechanism for dissemination of the Rutgers Maps. These resources have served, and continue to serve, an important role in the international genetics research community, for studies in humans as well as other species. The basis for this claim comes from the numerous citations of our resource publications, many strong letters of support from current users, tallies of hits to our WWW/FTP sites, and the frequent and varying e-mail inquiries we receive. The Rutgers Mapping Resources have been used to help localize disease genes for many inherited genetic disorders with significant health impact. Under this proposal we will continue to develop these important resources in order to enhance and maintain their utility for investigators studying humans and other species. In particular, we propose to implement an interpolation method for placing physically-mapped markers onto our combined linkage-physical map, a feature which has growing importance as high-throughput genotyping technologies continue to advance. We will apply our combined-mapping procedure to data from the genome projects of non-human species such as mouse, rat, dog, and others. We will improve our MAP-O-MAT web server and develop a stand-alone shareable version. We will enhance our documentation, online help, and create useful new tutorials for all of our resources. We will also improve our resource integration and continue to maintain these resources while providing excellent user support. We remain fully committed to keeping all of our software and resources freely available. Our proposal is submitted under PAR-05-057 "Continued development and maintenance of software," which aims to "support the continued development, maintenance, testing and evaluation of existing software."