The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in Me

描述：髋部骨折是一种对个人和社会来说非常致残和代价高昂的疾病，典型的 被认为是老年女性的健康问题。然而，25%-30%的髋部骨折发生在男性， 到2025年，男性髋部骨折的发病率预计将与目前女性相同， 这使得这成为老年男性、他们的家人和医疗保健系统正在出现的公共卫生问题。 摘要：已知的有关髋部骨折后果的大部分研究都来自于 女人。2005年，美国国家老龄研究所授予马加齐纳博士荣誉奖(R37 AG09901)，以 将这项关于髋部骨折后果的工作扩展到包括对功能性、 男性髋部骨折的代谢、生理、肌肉和骨骼后果与 女人。拟议的辅助研究旨在扩大髋部骨折的调查范围。 通过检查骨骼强度、骨骼代谢、肌肉的变化轨迹进一步研究结果 髋部骨折后的成分、激素和炎症标志物，并通过比较这些 髋部骨折后一年内男性和女性的变化。确定此信息的方法是 重要的是，因为不知道男性和女性的区别，就不可能决定哪些信息 已经知道的患有髋部骨折的女性可以自信地适用于男性。 在这项研究的第一部分中，招募的男性和女性患有新的髋部骨折 家长研究将在骨骼强度和周转率、肌肉成分、激素等指标上进行比较 和炎症标志物。可直接获得辅助研究的措施或标本的地方 从父母研究中收集的信息中，200名男性与200名女性进行了比较。何时是新的 需要测量骨骼强度和肌肉成分，将在以下方面采取额外措施 男性和女性患者的子集。在本研究的构成部分2中，重点将转向确定变化 在可归因于男性髋部骨折的骨骼、肌肉、功能和新陈代谢的选定方面。这一目标 将通过比较组成1队列中的200名男性和年龄匹配的200名男性来完成 以及来自男性骨质疏松症研究(MOST)的种族/民族。两个组件的样本量都很大 足够多的人确实在纵向分析中发现了小到中等大小的差异。 连同在父项目中收集的信息，来自辅助项目的新信息 研究将使我们能够确定下一组病因学、预后和机制研究应该在哪里进行 有针对性，以及需要制定和测试哪些领域的干预措施以改善 男性和女性的髋部骨折。

Description: Hip fracture, a very disabling and costly condition to individuals and society, is typically thought of as a health problem of older women. However, 25-30 percent of hip fractures occur in men, and by 2025, the incidence of hip fracture in men is expected to be the same as that currently seen in women, making this an emerging public health concern for older men, their families, and the healthcare system. Abstract: Most of what is known about the consequences of hip fracture comes from studies of women. In 2005, the National Institute on Aging awarded Dr. Magaziner a Merit Award (R37 AG09901) to extend this body of work on the consequences of hip fracture to include an investigation of functional, metabolic, physiologic, muscular and skeletal consequences of hip fracture in men in comparison with women. The proposed ancillary study is designed to extend this investigation of the hip fracture consequences further by examining trajectories of change in bone strength, bone metabolism, muscle composition, hormones, and markers of inflammation following hip fracture, and by comparing these changes in men and women during the year following a hip fracture. Ascertaining this information is important since without knowing how men and women differ, it is not possible to decide which information already known about women who have hip fractures can be applied confidently to men. In Component 1 of this study, men and women who are being recruited with a new hip fracture for the parent study will be compared on measures of bone strength and turnover, muscle composition, hormones and inflammatory markers. Where measures or specimens for the ancillary study can be obtained directly from information collected as part of the parent study, 200 men will be compared to 200 women. When new measures of bone strength and muscle composition are required, additional measures will be made on a subset of male and female patients. In Component 2 of this study, emphasis will turn to identifying changes in selected aspects of bone, muscle, function, and metabolism attributable to hip fracture in men. This aim will be accomplished by comparing the 200 men in the Component 1 cohort with 200 men matched on age and race/ethnicity from the Male Osteoporosis Study (MOST). Sample sizes for both components are large enough do detect small to moderate sized differences in longitudinal analyses. Together with information being collected in the parent project, new information from the ancillary study will allow us to determine where the next set of etiologic, prognostic, and mechanistic studies should be targeted, and areas in which interventions need to be developed and tested to improve the outcomes of hip fracture in men and in women.