The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in Me

描述：髋部骨折，一个非常残疾和昂贵的条件，个人和社会，是典型的 被认为是老年妇女的健康问题。然而，25- 30%的髋部骨折发生在男性， 到2025年，男性髋部骨折的发病率预计将与目前女性的发病率相同， 这使得老年男性、他们的家庭和医疗保健系统成为一个新兴的公共卫生问题。 翻译后摘要：大多数什么是已知的后果髋部骨折来自研究， 妇女2005年，美国国家老龄问题研究所授予Magaziner博士一项优异奖（R37 AG 09901）， 扩展髋部骨折后果的研究范围， 男性髋部骨折的代谢、生理、肌肉和骨骼后果， 妇女建议的辅助研究旨在扩展髋部骨折的调查 通过检查骨强度、骨代谢、肌肉收缩和收缩的变化轨迹， 成分，激素和炎症标志物，并通过比较这些 男性和女性在髋部骨折后一年内的变化。确定这些信息是 重要的是，如果不知道男女之间的差异，就不可能决定哪些信息是重要的， 已经知道的关于髋部骨折的女性的方法可以自信地应用于男性。 在本研究的第1部分中，招募了新的髋部骨折的男性和女性， 将在骨强度和骨转换、肌肉成分、激素水平等指标上对母研究进行比较 和炎症标志物。可直接获得辅助研究的测量值或样本 根据作为母公司研究的一部分收集的信息，将对200名男性和200名女性进行比较。当新 需要测量骨强度和肌肉成分，将对 男性和女性患者的子集。在本研究的第二部分，重点将转向确定变化， 在骨、肌肉、功能和代谢的选定方面，可归因于男性髋部骨折。这一目标 将通过比较组分1队列中的200名男性与年龄匹配的200名男性来完成 男性骨质疏松症研究（MOST）的种族/民族。两个组件的样本量都很大 在纵向分析中足以检测到小到中等大小的差异。 与父项目中收集的信息一起， 这项研究将使我们能够确定下一组病因学、预后和机制研究应该在哪里进行。 目标明确，以及需要制定和测试干预措施以改善 男性和女性髋部骨折。

Description: Hip fracture, a very disabling and costly condition to individuals and society, is typically thought of as a health problem of older women. However, 25-30 percent of hip fractures occur in men, and by 2025, the incidence of hip fracture in men is expected to be the same as that currently seen in women, making this an emerging public health concern for older men, their families, and the healthcare system. Abstract: Most of what is known about the consequences of hip fracture comes from studies of women. In 2005, the National Institute on Aging awarded Dr. Magaziner a Merit Award (R37 AG09901) to extend this body of work on the consequences of hip fracture to include an investigation of functional, metabolic, physiologic, muscular and skeletal consequences of hip fracture in men in comparison with women. The proposed ancillary study is designed to extend this investigation of the hip fracture consequences further by examining trajectories of change in bone strength, bone metabolism, muscle composition, hormones, and markers of inflammation following hip fracture, and by comparing these changes in men and women during the year following a hip fracture. Ascertaining this information is important since without knowing how men and women differ, it is not possible to decide which information already known about women who have hip fractures can be applied confidently to men. In Component 1 of this study, men and women who are being recruited with a new hip fracture for the parent study will be compared on measures of bone strength and turnover, muscle composition, hormones and inflammatory markers. Where measures or specimens for the ancillary study can be obtained directly from information collected as part of the parent study, 200 men will be compared to 200 women. When new measures of bone strength and muscle composition are required, additional measures will be made on a subset of male and female patients. In Component 2 of this study, emphasis will turn to identifying changes in selected aspects of bone, muscle, function, and metabolism attributable to hip fracture in men. This aim will be accomplished by comparing the 200 men in the Component 1 cohort with 200 men matched on age and race/ethnicity from the Male Osteoporosis Study (MOST). Sample sizes for both components are large enough do detect small to moderate sized differences in longitudinal analyses. Together with information being collected in the parent project, new information from the ancillary study will allow us to determine where the next set of etiologic, prognostic, and mechanistic studies should be targeted, and areas in which interventions need to be developed and tested to improve the outcomes of hip fracture in men and in women.