The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in Me

我髋部骨折后骨强度和肌肉成分的流行病学

• 批准号: 8046338
• 负责人: JAY MAGAZINER
• 金额: $ 54.49万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046338
• 关键词: 25-hydroxyvitamin D; Affect; Age; Alkaline Phosphatase; Ancillary Study; Area; Award; C-reactive protein; C-terminal; Clinical; Collagen Type I; Communities; Data; Disease; Epidemiology; Estradiol; Ethnic Origin; Event; Family; Female; Finite Element Analysis; Fracture; Goals; Health; Healthcare Systems; Hip Fractures; Hip region structure; Hormones; Incidence; Individual; Insulin-Like Growth Factor I; Interleukin-6; Intervention; Investigation; Knowledge; Measures; Metabolic; Metabolism; Muscle; Muscle function; Musculoskeletal; N-terminal; National Institute on Aging; Osteoporosis; Outcome; Parathyroid gland; Parents; Patients; Physiological; Positioning Attribute; Process; Public Health; Race; Recruitment Activity; Research Personnel; Sample Size; Scanning; Science; Serum; Sex Characteristics; Societies; Specimen; Testing; Testosterone; Thigh structure; Type I Procollagen; Vertebral column; Woman; Work; X-Ray Computed Tomography; abstracting; base; bone; bone metabolism; bone strength; bone turnover; cohort; crosslink; design; experience; human TNFRSF1A protein; improved; inflammatory marker; male; men; muscle metabolism; older men; older women; parent project; prognostic; programs; sex; skeletal; tumor necrosis factor alpha receptor

DESCRIPTION (provided by applicant): Description: Hip fracture, a very disabling and costly condition to individuals and society, is typically thought of as a health problem of older women. However, 25-30 percent of hip fractures occur in men, and by 2025, the incidence of hip fracture in men is expected to be the same as that currently seen in women, making this an emerging public health concern for older men, their families, and the healthcare system. Abstract: Most of what is known about the consequences of hip fracture comes from studies of women. In 2005, the National Institute on Aging awarded Dr. Magaziner a Merit Award (R37 AG09901) to extend this body of work on the consequences of hip fracture to include an investigation of functional, metabolic, physiologic, muscular and skeletal consequences of hip fracture in men in comparison with women. The proposed ancillary study is designed to extend this investigation of the hip fracture consequences further by examining trajectories of change in bone strength, bone metabolism, muscle composition, hormones, and markers of inflammation following hip fracture, and by comparing these changes in men and women during the year following a hip fracture. Ascertaining this information is important since without knowing how men and women differ, it is not possible to decide which information already known about women who have hip fractures can be applied confidently to men. In Component 1 of this study, men and women who are being recruited with a new hip fracture for the parent study will be compared on measures of bone strength and turnover, muscle composition, hormones and inflammatory markers. Where measures or specimens for the ancillary study can be obtained directly from information collected as part of the parent study, 200 men will be compared to 200 women. When new measures of bone strength and muscle composition are required, additional measures will be made on a subset of male and female patients. In Component 2 of this study, emphasis will turn to identifying changes in selected aspects of bone, muscle, function, and metabolism attributable to hip fracture in men. This aim will be accomplished by comparing the 200 men in the Component 1 cohort with 200 men matched on age and race/ethnicity from the Male Osteoporosis Study (MOST). Sample sizes for both components are large enough do detect small to moderate sized differences in longitudinal analyses. Together with information being collected in the parent project, new information from the ancillary study will allow us to determine where the next set of etiologic, prognostic, and mechanistic studies should be targeted, and areas in which interventions need to be developed and tested to improve the outcomes of hip fracture in men and in women.

描述(申请人提供)：描述：髋部骨折，一种对个人和社会来说非常致残和代价高昂的疾病，通常被认为是老年妇女的健康问题。然而，25%-30%的髋部骨折发生在男性，到2025年，男性髋部骨折的发病率预计将与目前在女性中看到的相同，这使这成为老年男性、他们的家人和医疗体系正在出现的公共卫生问题。摘要：人们对髋部骨折后果的了解大多来自对女性的研究。2005年，美国国家老龄研究所授予Magaziner博士优秀奖(R37 AG09901)，以扩大这项关于髋部骨折后果的研究，将髋部骨折对男性和女性的功能、代谢、生理、肌肉和骨骼后果进行比较研究。这项拟议的辅助研究旨在通过检查髋部骨折后骨强度、骨代谢、肌肉成分、激素和炎症标志物的变化轨迹，并通过比较髋部骨折后一年内男性和女性的这些变化，进一步扩展对髋部骨折后果的调查。确定这一信息很重要，因为在不知道男性和女性有何不同的情况下，无法决定哪些已知的关于髋部骨折的女性信息可以自信地应用于男性。在这项研究的第一部分中，父母研究招募的患有新髋部骨折的男性和女性将在骨骼强度和周转率、肌肉成分、激素和炎症标记物的测量方面进行比较。如果辅助研究的测量或标本可以直接从作为父母研究一部分收集的信息中获得，则将200名男性与200名女性进行比较。当需要对骨骼强度和肌肉成分进行新的测量时，将对部分男性和女性患者进行额外的测量。在这项研究的第二部分，重点将转向确定可归因于男性髋部骨折的骨骼、肌肉、功能和新陈代谢的选定方面的变化。这一目标将通过比较第一组中的200名男性与男性骨质疏松症研究(MOST)中在年龄和种族/民族方面匹配的200名男性来实现。两种成分的样本量都足够大，在纵向分析中确实可以检测到小到中等大小的差异。与母项目中收集的信息一起，来自辅助研究的新信息将使我们能够确定下一组病因、预后和机制研究的目标，以及需要开发和测试干预措施的领域，以改善男性和女性髋部骨折的结果。