Prostaglandins & Oxidative Damage in ADAPT Participants
Prostaglandins & Oxidative Damage in ADAPT Participants
批准号:
7273520
负责人:
John C S Breitner
金额:
$29.43万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-09-30 至 2009-08-31
关键词:
AftercareAge-associated memory impairmentAlzheimer disease preventionAlzheimer&aposs DiseaseAnti-Inflammatory AgentsAnti-inflammatoryAspirinBiological AssayBiological MarkersClinicalClinical ResearchClinical TreatmentClinical TrialsCultured CellsDataDementiaDoseDrug usageDrug userEicosanoid ProductionEnd PointEnrollmentEnzymesEpidemiologic StudiesFoundationsFundingGoalsHumanIbuprofenImpaired cognitionIncidenceIndividualLaboratoriesLipid PeroxidationMeasuresNeuraxisOutcomeParticipantPathogenesisPathologic ProcessesPatientsPeptidesPharmaceutical PreparationsPhasePreventionProceduresProcessProductionProstaglandin ProductionProstaglandin-Endoperoxide SynthaseProstaglandinsRateResearch PersonnelResourcesSpecimenStagingTestingTransgenic MiceTreatment Efficacycyclooxygenase 1cyclooxygenase 2insightpre-clinicalpreventprogesterone 11-hemisuccinate-(2-iodohistamine)protective effect
中文摘要
几项大型流行病学研究表明,老年痴呆症的发病率显著降低
英文摘要
Several large epidemiological studies have associated a profound reduction in the incidence of Alzheimer's
Disease (AD) in older individuals who took non-steroidal anti-inflammatory drugs (NSAIDs) for longer than
2 years. However, clinical trials of NSAIDs in patients with established AD failed to show efficacy. This has
led to the hypothesis that NSAIDs suppress pathologic processes critical to the initiation of AD and that these
processes may be related to inhibition of the cyclooxygenase enzymes and subsequent prostaglandin (PG)
production. We propose to test this hypothesis by quantifying endogenous eicosanoid production in subjects
enrolled in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT), an NIA-sponsored study
of NSAIDs in the prevention of AD. Specifically, we will 1) determine the efficacy of selective and non-
selective NSAIDs t o suppress 1 evels o f quantitative b iomarkers o f P G p reduction systemically and in t he
central nervous system of ADAPT participants; 2) determine the efficacy of NSAIDs to suppress levels of
quantitative biomarkers of oxidative damage systemically and in the central nervous system of ADAPT
participants; and 3) correlate changes in the levels of biomarkers of PG production and oxidative damage
with rates of cognitive decline as determined in ADAPT. We have developed highly accurate and precise
mass spectrometric assays to quantify PGs, PG metabolites, and lipid peroxidation products and are routinely
performing these assays in our laboratory. These studies will provide important insights into the mechanisms
by which NSAIDs prevent AD.
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Prostaglandins & Oxidative Damage in ADAPT Participants
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批准号:6794320
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项目类别:
-
资助金额:$28.54万
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财政年份:2003
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负责人:John C S Breitner
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依托单位:
Prostaglandins & Oxidative Damage in ADAPT Participants
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批准号:6933146
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项目类别:
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资助金额:$31.04万
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财政年份:2003
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负责人:John C S Breitner
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依托单位:
Prostaglandins & Oxidative Damage in ADAPT Participants
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批准号:6802719
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项目类别:
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资助金额:$27.89万
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财政年份:2003
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负责人:John C S Breitner
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依托单位:
Prostaglandins & Oxidative Damage in ADAPT Participants
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批准号:7119183
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项目类别:
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资助金额:$30.31万
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财政年份:2003
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6725374
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项目类别:
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资助金额:$421.11万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6502289
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项目类别:
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资助金额:$12.4万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
Prevention of Alzheimer Dementia and Cognitive Decline
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批准号:7916459
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项目类别:
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资助金额:$286.98万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:7049675
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项目类别:
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资助金额:$613.16万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6754733
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项目类别:
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资助金额:$10.0万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6041161
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项目类别:
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资助金额:$478.78万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6362223
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项目类别:
-
资助金额:$679.78万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6594396
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项目类别:
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资助金额:$12.01万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6509864
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项目类别:
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资助金额:$518.82万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:6682750
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项目类别:
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资助金额:$560.46万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
PREVENTION OF ALZHEIMER DEMENTIA & COGNITIVE DECLINE
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批准号:7188320
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项目类别:
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资助金额:$539.7万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
Prevention of Alzheimer Dementia and Cognitive Decline
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批准号:7467669
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项目类别:
-
资助金额:$311.58万
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财政年份:2000
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负责人:John C S Breitner
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依托单位:
HEAD INJURY & ALZHEIMER'S DISEASE
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批准号:2294208
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项目类别:
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资助金额:$23.37万
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财政年份:1994
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负责人:John C S Breitner
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依托单位:
HEAD INJURY & ALZHEIMER'S DISEASE
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批准号:2294206
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项目类别:
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资助金额:$118.12万
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财政年份:1994
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负责人:John C S Breitner
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依托单位:
EPIDEMIOLOGY OF ALZHEIMERS DEMENTIA IN CACHE COUNTY UT
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批准号:2052560
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项目类别:
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资助金额:$140.1万
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财政年份:1994
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负责人:John C S Breitner
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依托单位:
HEAD INJURY & ALZHEIMER'S DISEASE
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批准号:2294204
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项目类别:
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资助金额:$72.41万
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财政年份:1994
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负责人:John C S Breitner
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依托单位:
海外基金