High-precision dosimetry for ultra-short, high dose-rate irradiation sources
超短、高剂量率照射源的高精度剂量测定
基本信息
- 批准号:2892817
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The projects aims at developing and testing new methods for high-precision dosimetry in a novel regime of irradiation of biological samples, with the final aim of establishing a new scheme for radiotherapeutic cancer treatment.Recent work carried out by our group has demonstrated that laser-driven electron and photon beams can access unprecedented regimes of cell response to radiation, with the clear potential to provide significant benefit to patients undergoing radiotherapeutic treatment. In particular, we have demonstrated the possibility of delivering Gy-scale irradiations over ultra-short temporal scales, tuneable from tens of picoseconds down to tens of femtoseconds, resulting in ground-breaking dose rates in the range of 10^11 - 10^14 Gy/s, well beyond the recently discovered FLASH effect. Notably, preliminary work carried out by our group has demonstrated novel features in the response of both healthy and tumour cells, with a significant increase in sparing of healthy tissues and increase in cell killing for tumour cells.In order to continue work in this direction, and precisely establish the effects of ultra-short irradiation on cells, it is mandatory to have precise measurements of the dose delivered to both in-vitro and in-vivo samples. While dosimetric techniques and diagnostics are well established for relatively long irradiation times, detailed work must be done to establish techniques for precise dosimetry at the sub-picosecond level. The group of Prof. Giuseppe Schettino at the National Physics Laboratory (NPL) is a world-leader in dosimetry, and responsible for developing and maintaining the UK primary dosimetry standard which are disseminated to all UK radiotherapy centres. We thus plan to team up with them to study ultra-fast dosimetry that can have deep and far-reaching repercussions in radiobiology and cancer treatment. The successful student will be jointly supervised by myself and Prof. Schettino and, while they will be based for the majority of their time at QUB, they will have placements at NPL. This work at the frontier of both radiation generation and applications will allow the student to gain expertise in a wide range of cutting-edge physical and engineering techniques, such as generating laser-driven ultra-fast radiation sources, characterising them, and developing dosimetric techniques. This work naturally aligns with my research interests, as demonstrated by the sustained funding obtained from research councils on the application of laser-driven radiation and particle sources (£ >10M overall funding secured from research councils in the last 10 years on this topic). This studentship will also complement a research proposal to EPSRC in this area (with NPL as project partner), planned to be submitted in the first half of 2023 in collaboration with the School of Pharmacy and the Centre for Cancer Research & Cell Biology (expected overall value £ >1.5M).The proposed work also naturally aligns with key research priorities within QUB, as demonstrated, for example, by the recent establishment of the Advanced Manufacturing Innovation Centre, and the Institute for Research Excellence in Advanced Clinical Healthcare.
该项目旨在开发和测试在生物样品辐照的新机制中进行高精度剂量测定的新方法,最终目的是建立放射性癌症治疗的新方案。我们小组最近进行的工作表明,激光驱动的电子和光子束可以进入前所未有的细胞对辐射的反应机制,具有为接受放射治疗的患者提供显著益处的明显潜力。特别是,我们已经证明了在超短时间尺度上提供Gy级辐射的可能性,从几十皮秒到几十飞秒可调,导致突破性的剂量率在10^11 - 10^14戈伊/s的范围内,远远超过了最近发现的FLASH效应。值得注意的是,我们小组进行的初步工作已经证明了健康细胞和肿瘤细胞的反应具有新的特征,健康组织的保留率显著增加,肿瘤细胞的细胞杀伤率增加。为了继续这一方向的工作,并精确地建立超短辐射对细胞的影响,必须精确测量传递到体外和体内样品的剂量。虽然相对较长的辐照时间的剂量测定技术和诊断方法已经很成熟,但必须开展详细的工作,以建立亚皮秒级的精确剂量测定技术。国家物理实验室(NPL)的Giuseppe Schettino教授小组是剂量学领域的世界领导者,负责制定和维护英国主要剂量学标准,并将其分发给所有英国放射治疗中心。因此,我们计划与他们合作研究超快剂量测定法,这对放射生物学和癌症治疗有着深远的影响。成功的学生将由我和Schettino教授共同监督,虽然他们大部分时间将在QUB工作,但他们将在NPL实习。在辐射产生和应用的前沿这项工作将使学生获得广泛的尖端物理和工程技术的专业知识,如产生激光驱动的超快辐射源,表征它们,并开发剂量测定技术。这项工作自然符合我的研究兴趣,正如从研究委员会获得的持续资金所证明的那样,激光驱动辐射和粒子源的应用(在过去的10年里,研究委员会在这一主题上获得了1000万英镑的总资金)。该奖学金还将补充EPSRC在该领域的研究提案(与NPL作为项目合作伙伴),计划于2023年上半年与药学院和癌症研究与细胞生物学中心合作提交(预期总价值£ > 150万)。拟议的工作也自然与QUB内的关键研究优先事项保持一致,例如,最近成立了先进制造创新中心和先进临床医疗卓越研究所。
项目成果
期刊论文数量(0)
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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用于实时测量循环生物标志物的植入式生物传感器微系统
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