Brain-informed high-precision stimulation to improve memory

大脑信息高精度刺激提高记忆力

• 批准号: 2893289
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2893289
• 关键词: Brain; informed; precision; stimulation; improve

Studentship strategic priority area: Basic and clinical researchKeywords: Neurotechnology, Closed-loop Stimulation, Hippocampus, Theta oscillations, MemoryAbstract: Memories are what make us unique. Diseases like Alzheimer's Dementia (AD) lead to a complete loss of memory with dramatic consequences for the individual and their family. Currently, no treatments exist to restore memory functions in these patients. Interventions that target memory supporting circuits with high precision in time and space are needed to support memory functions in these patients. The ability to store memories depends on at least two brain mechanisms. First, a precise level of synchronization in memory supporting circuits which involve the prefrontal cortex and the hippocampus. Second, a precise balance between excitatory and inhibitory neural activity. Both neural synchronization and excitation/inhibition balance are affected by AD. From the past literature, we know that there is considerable variability in brain activity between individuals and within an individual from one moment to the next. Therefore, stimulating an individual brain with a fixed set of parameters is unlikely to benefit memory in a consistent and effective manner. The project aims to explore the potential of individualized high precision brain stimulation protocols to improve memory function consistently on the individual level, which could potentially be used to restore memory in patients suffering from AD. The experiments will involve testing healthy human participants but also rodent animal models, in collaboration with our industrial partner Braingrade GmbH (www.braingrade.io). In this context, the efficacy of a memory enhancing neuroprostetic will be tested in a non-human primate model. This device directly interacts with the memory brain dynamics mentioned before to apply stimulation dependent on ongoing brain activity.

学生奖学金战略优先领域：基础和临床研究关键词：神经技术，闭环刺激，海马，θ振荡，记忆摘要：记忆是什么让我们独特。阿尔茨海默氏症（AD）等疾病会导致记忆完全丧失，对个人及其家庭造成严重后果。目前，没有治疗方法可以恢复这些患者的记忆功能。需要针对在时间和空间上具有高精度的记忆支持回路的干预来支持这些患者的记忆功能。存储记忆的能力取决于至少两种大脑机制。第一，记忆支持回路中的精确同步水平，包括前额皮质和海马体。第二，兴奋和抑制神经活动之间的精确平衡。AD影响神经元的同步化和兴奋/抑制平衡。从过去的文献中，我们知道个体之间和个体内部的大脑活动从一个时刻到下一个时刻存在相当大的差异。因此，用一组固定的参数刺激个体大脑不太可能以一致和有效的方式有益于记忆。该项目旨在探索个性化高精度脑刺激方案的潜力，以在个体水平上持续改善记忆功能，这可能用于恢复AD患者的记忆。这些实验将包括与我们的工业合作伙伴Braingrade GmbH（www.braingrade.io）合作测试健康的人类参与者以及啮齿动物模型。在这种情况下，将在非人灵长类动物模型中测试增强记忆的神经前列腺剂的功效。该设备直接与之前提到的记忆脑动力学相互作用，以根据正在进行的大脑活动施加刺激。