Development of a Highly Efficient Personal Sampler to collect Viable Bioaerosols

开发高效个人采样器来收集活性生物气溶胶

• 批准号: 7319515
• 负责人: YUNG SUNG CHENG
• 金额: $ 44.71万
• 依托单位: LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7319515
• 关键词: Development; Highly; Efficient; Personal; Sampler

DESCRIPTION (provided by applicant): Exposures to bioaerosols in the workplace have become a significant issue in recent years. It is essential to be able to accurately assess these potential health risks. Furthermore, because each person will react differently, it is necessary to perform such assessments on an individual basis. Workplace bioaerosols include bacteria, fungi, viruses, microbial toxins and various allergens. Numerous devices exist that are capable of collecting bioaerosols, but many are not designed for personal use. Additionally, the majority of existing devices confer a high degree of biological stress resulting in a significant loss in viability. Preservation of viability is crucial for accurate exposure assessments in that viable microorganisms pose a greater health risk. This proposal has four objectives: (1) to design and construct a personal bioaerosol sampler incorporating a re-circulating liquid cyclone collection medium, (2) to test the sampling efficiency of the proposed personal sampler in an aerosol wind tunnel for aspiration efficiency, (3) to evaluate the sampler using model bioaerosols with a focus on the effects of sampling on microbial viability, and (4) to evaluate the sampler placed on the lapel of a mannequin at different wind directions in a wind tunnel. Relevance: This research will lead to the development of a unique, highly efficient personal bioaerosol sampler capable of collecting the inhalable participate mass and retaining microbial viability. The new device will not only be beneficial in occupational settings, but may also have future potential in high risk areas such as those following any possible biological attack.

描述（由申请人提供）：近年来，工作场所的生物气溶胶暴露已成为一个重要问题。必须能够准确评估这些潜在的健康风险。此外，由于每个人的反应不同，因此有必要在个人基础上进行这种评估。工作场所的生物气溶胶包括细菌、真菌、病毒、微生物毒素和各种过敏原。存在许多能够收集生物气溶胶的设备，但许多设备不是为个人使用而设计的。此外，大多数现有器械会产生高度的生物应力，导致生存力显著丧失。保持存活力对于准确的接触评估至关重要，因为存活的微生物会造成更大的健康风险。该提案有四个目标：（1）设计和建造一个包含再循环液体旋流收集介质的个人生物气溶胶采样器，（2）在气溶胶风洞中测试拟议的个人采样器的采样效率，以获得抽吸效率，（3）使用模型生物气溶胶评估采样器，重点是采样对微生物活力的影响，（4）在风洞中对置于人体模型翻领上的样品在不同风向下进行评估。相关性：这项研究将导致开发一种独特的，高效的个人生物气溶胶采样器，能够收集可吸入的参与质量和保留微生物的活力。新设备不仅在职业环境中有益，而且在高风险领域也有潜力，例如在任何可能的生物攻击之后。