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Development of a Personal Sampler for Nanoparticles

纳米颗粒个人采样器的开发

基本信息

批准号：
8288610
负责人：
YUNG SUNG CHENG
金额：
$ 48.16万
依托单位：
LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8288610
关键词：
Development Personal Sampler Nanoparticles

项目摘要

Project Summary Production of nanomaterials has increased continuously because of their unique physicochemical characteristics and extensive applications. There are great concerns for the potential health effects of exposure to these nanoparticles. Because of nanomaterials' small sizes and large surface areas, many studies have shown that the biological effects of nanomaterials are greater than bulk material of the same chemical composition. In 2005, the NIOSH recommended exposure limits of 1.5 mg/m3 for fine TiO2 and 0.1 mg/m3 for ultrafine TiO2, as time-weighted average concentrations (TWA) for up to 10 hr/day during a 40-hr work week. However, there are no suitable personal samplers capable of assessing the exposure level of ultrafine or nanoparticles. The overall objective of this study is to develop a personal sampler capable of collecting the ultrafine particles (nanoparticles) in the occupational environment. This sampler consists of a cyclone for respirable particle classification, a polycarbonate track-etched (PCTE) membrane filter with an acceleration nozzle to achieve nanoparticle classification, and a backup filter to collect nanoparticles. By applying high and localized filtration velocity in the nozzle, diffusion deposition of nanoparticles can be avoided in the classifying PCTE filter, and nanoparticles can be collected in the downstream backup filter. This research will lead to the development of a unique personal sampling device capable of classifying the nanoparticle fraction (d 100 nm) from the aerosol stream and collecting this fraction for gravimetric, chemical, and other analyses. This device can be used to accurately assess personal exposure to nanoparticles in terms of mass concentration and physicochemical characteristics.

项目摘要由于其独特的物理化学特性，纳米材料的产量不断增加。特点和广泛的应用。有很大的担忧，对健康的潜在影响暴露在这些纳米颗粒中。由于纳米材料的小尺寸和大表面积，许多研究表明，纳米材料的生物效应比块状材料更大。化学成分。2005年，NIOSH建议细二氧化钛的暴露限值为1.5毫克/立方米和0.1毫克/立方米毫克/立方米对于超细二氧化钛，作为时间加权平均浓度(TWA)，在40小时内最多10小时/天每周工作。然而，目前还没有合适的个人采样器来评估其暴露水平。超细或纳米颗粒。这项研究的总体目标是开发一种个人采样器，能够收集职业环境中的超细颗粒(纳米颗粒)。此采样器由一个用于可吸入颗粒物分类的旋风除尘器，聚碳酸酯径迹刻蚀(PCTE)膜过滤器加速喷嘴实现纳米颗粒分类，后备过滤器收集纳米颗粒。通过在喷嘴中应用高的局部过滤速度，可以避免纳米颗粒的扩散沉积。在分级PCTE过滤器中，纳米颗粒可以收集在下游的备用过滤器中。这研究将导致开发一种独特的个人采样设备，能够对纳米颗粒(D 100 Nm)从气溶胶气流中分离出来，收集这些颗粒用于重量分析、化学、和其他分析。这种装置可以用来准确地评估个人对纳米颗粒的暴露质量浓度和物理化学特性。