Retrovial Infections of the Nervous System in Peru

秘鲁神经系统的逆行感染

• 批准号: 7461911
• 负责人: JOSEPH Raymond ZUNT
• 金额: $ 4.61万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-10 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7461911
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Adult; Blood; Blood Banks; Blood Donations; Blood donor; Blood donor screening; Brain; Brain Diseases; CD4 Lymphocyte Count; Capital; Case Series; Case-Control Studies; Cell Count; Central Nervous System Infections; Childhood; Cities; Classification; Clinic; Clinical; Clinical Investigator; Clinical Research; Cognitive; Cohort Studies; Collaborations; Communicable Diseases; Complement; Contracts; Counseling; Country; Dental; Descriptive Epidemiology; Development; Diagnosis; Diagnostic; Enrollment; Enzyme-Linked Immunosorbent Assay; Faculty; Family Study; Female; Foundations; Funding; Future; General Population; Goals; Grant; HIV; HIV Infections; HTLV Infection; HTLV-II Infections; Health; Health Personnel; Health Professional; Hepatitis C; Hepatitis C virus; High Prevalence; Human Subject Research; Human T-lymphotropic virus 1; Human T-lymphotropic virus 2; Human immunodeficiency virus test; Immune; Incidence; Infection; Institutes; Institution; International AIDS; Investigation; Laboratories; Letters; Maintenance; Malaria; Measures; Medical; Medical Research; Meningoencephalitis; Mentors; Morbidity - disease rate; Natural History; Nervous system structure; Neurocysticercosis; Neurologic; Neurologic Examination; Neurologic Manifestations; Neurologist; Neuropathy; Neurosciences; Neurosciences Research; Numbers; Other Finding; Outcome; Outcome Study; Pathogenesis; Pathology; Patients; Persons; Peru; Pneumonia; Polymerase Chain Reaction; Population; Prevalence; Principal Investigator; Prospective Studies; Public Health; Public Health Informatics; Rate; Research; Research Design; Research Methodology; Research Personnel; Research Training; Retroviridae; Retrovirology; Risk; Risk Factors; Ritual compulsion; Screening procedure; Sexual Partners; Site; Spinal Cord Diseases; Symptoms; Techniques; Technology Transfer; Testing; Time; Training; Training Activity; Training Programs; Training and Education; Tropical Medicine; Trust; United States; United States National Institutes of Health; Universities; Viral Load result; Viral load measurement; Washington; Western Blotting; Work; X-Ray Computed Tomography; base; case control; clinical epidemiology; clinical research site; cohort; design; experience; informatics training; interest; international center; medical schools; mortality; nervous system infection; pathogen; programs; protocol development; rectal; sex; success; symposium; transmission process; treatment trial; virology

The overarching goals of this RO1 application are to study the clinical epidemiology and pathogenesis of retroviral, opportunistic and tropical infections of the nervous system in Peru, building on research collaborations and investigations initiated during the R21 grant entitled "Central Nervous System Infections in Peru"; and to continue development of neurologist investigators in academic and research institutions in selected cities throughout Peru. The specific aims of this grant are to 1) define the risk determinants and clinical manifestations of HTLV-II, HTLV-I, HIV infections and of coinfections with two or more of these three retroviral pathogens in the four largest cities in Peru; 2) establish a national reference center for clinical research on HTLV infection for conduct of cohort studies of the natural history, clinical manifestations, and pathogenesis of HTLV-I and -II infections in persons referred from blood banks; and 3) examine the influence of these three retroviral infections on the natural history of opportunistic and tropical infections of the CNS in persons with retroviral infection. During our R21 planning grant, we discovered that HTLV-II infection was unexpectedly prevalent in selected populations in Lima (the capital) and two of the largest cities in the Amazon Jungle. In addition, we developed research collaborations with neurologists in Lima (the capital), Iquitos (Jungle), Arequipa (Andes Mountains), and Trujillo (Coast), and determined the most common manifestations of neuroAIDS in Iquitos and Arequipa; and through conferences and in-country training, provided research and human subjects training to over 200 experienced and new clinical investigators - many of them neurologists. Concurrently, UW-led HIV/AIDS-related research funding in Peru has grown to $5,000,000 per year from NIH and from private foundations, providing an outstanding foundation for further development of a CNS retroviral research program. The Collaborative Network for Tropical Neurologic Infectious Diseases established with researchers in nongovernmental and Ministry of Health institutions in Peru, with the U.S. Naval Medical Research Center Detachment (NMRCD) in Peru, and with Universities in Peru and the United States, will support future research on the clinical epidemiology of retroviral infections and their interactions with emerging tropical infections in Peru and eventually the Andean Region. In addition to continuing our investigations, we plan to continue training activities to address the research, education, training, and mentoring needs and opportunities related to CNS infection identified during the R21 planning grant.

该RO 1应用程序的首要目标是研究临床流行病学， 秘鲁神经系统逆转录病毒、机会性和热带感染的发病机制， 关于在R21赠款期间发起的题为“中枢神经系统”的研究合作和调查 秘鲁的系统感染”;并继续在学术和 在整个秘鲁选定的城市的研究机构。该补助金的具体目标是：1） 定义HTLV-II、HTLV-I、HIV感染和HTLV-II的风险决定因素和临床表现 在秘鲁的四个最大城市中同时感染这三种逆转录病毒病原体中的两种或两种以上; 2） 建立国家HTLV感染临床研究参考中心进行队列研究 研究自然史，临床表现，和HTLV-I和-II感染的发病机制， 从血库转介的人;和3）研究这三种逆转录病毒感染的影响 关于逆转录病毒感染者中枢神经系统机会性感染和热带感染的自然史 感染在我们的R21计划拨款期间，我们发现HTLV-II感染出乎意料地 在首都利马和亚马逊河流域两个最大城市的特定人群中流行 丛林此外，我们还与首都利马的神经科医生开展了研究合作， 伊基托斯（丛林），阿雷基帕（安第斯山脉）和特鲁希略（海岸），并确定了最常见的 伊基托斯和阿雷基帕的神经艾滋病表现;并通过会议和国内 培训，为200多名经验丰富的新临床医生提供研究和人体受试者培训。 调查员--其中很多是神经学家。同时，UW领导的艾滋病毒/艾滋病相关的研究资金 在秘鲁，每年从国家卫生研究院和私人基金会获得的捐款已增至500万美元， 为进一步发展CNS逆转录病毒研究计划奠定了良好的基础。的 热带神经系统传染病合作网络与研究人员在 非政府组织和秘鲁卫生部机构，与美国海军医学研究所 在秘鲁的国家排雷中心分遣队以及在秘鲁和美国的大学，将 支持今后对逆转录病毒感染的临床流行病学及其与 在秘鲁以及最终在安第斯地区出现的热带感染。除了继续我们的 调查，我们计划继续培训活动，以解决研究，教育，培训， 在R21规划补助金期间确定的与CNS感染相关的指导需求和机会。