Retrovial Infections of the Nervous System in Peru

秘鲁神经系统的逆行感染

• 批准号: 7619567
• 负责人: JOSEPH Raymond ZUNT
• 金额: $ 55.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-10 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7619567
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Adult; Blood; Blood Banks; Blood Donations; Blood donor; Blood donor screening; Brain; Brain Diseases; CD4 Lymphocyte Count; Capital; Case Series; Case-Control Studies; Cell Count; Central Nervous System Infections; Childhood; Cities; Classification; Clinic; Clinical; Clinical Investigator; Clinical Research; Cognitive; Cohort Studies; Collaborations; Communicable Diseases; Complement; Contracts; Counseling; Country; Dental; Descriptive Epidemiology; Development; Diagnosis; Diagnostic; Enrollment; Enzyme-Linked Immunosorbent Assay; Faculty; Family Study; Female; Foundations; Funding; Future; General Population; Goals; Grant; HIV; HIV Infections; HTLV Infection; HTLV-II Infections; Health; Health Personnel; Health Professional; Hepatitis C; Hepatitis C virus; High Prevalence; Human Subject Research; Human T-lymphotropic virus 1; Human T-lymphotropic virus 2; Human immunodeficiency virus test; Immune; Incidence; Infection; Institutes; Institution; Investigation; Laboratories; Letters; Maintenance; Malaria; Measures; Medical; Medical Research; Meningoencephalitis; Mentors; Morbidity - disease rate; Natural History; Nervous system structure; Neurocysticercosis; Neurologic; Neurologic Examination; Neurologic Manifestations; Neurologist; Neuropathy; Neurosciences; Neurosciences Research; Outcome; Outcome Study; Pathogenesis; Pathology; Patients; Persons; Peru; Pneumonia; Population; Prevalence; Principal Investigator; Prospective Studies; Public Health; Public Health Informatics; Research; Research Design; Research Methodology; Research Personnel; Research Training; Retroviridae; Retrovirology; Risk; Risk Factors; Ritual compulsion; Screening procedure; Sexual Partners; Site; Spinal Cord Diseases; Symptoms; Techniques; Technology Transfer; Testing; Time; Training; Training Activity; Training Programs; Training and Education; Tropical Medicine; Trust; United States; United States National Institutes of Health; Universities; Viral Load result; Viral load measurement; Washington; Western Blotting; Work; X-Ray Computed Tomography; base; blood product; case control; clinical epidemiology; clinical research site; cohort; design; experience; high risk; informatics training; interest; international center; medical schools; mortality; nervous system infection; pathogen; programs; protocol development; rectal; responsible research conduct; sex; success; symposium; transmission process; treatment trial; virology

DESCRIPTION (provided by applicant): The overarching goals of this RO1 application are to study the clinical epidemiology and pathogenesis of retroviral, opportunistic and tropical infections of the nervous system in Peru, building on research collaborations and investigations initiated during the R21 grant entitled "Central Nervous System Infections in Peru"; and to continue development of neurologist investigators in academic and research institutions in selected cities throughout Peru. The specific aims of this grant are to 1) define the risk determinants and clinical manifestations of HTLV-II, HTLV-I, HIV infections and of coinfections with two or more of these three retroviral pathogens in the four largest cities in Peru; 2) establish a national reference center for clinical research on HTLV infection for conduct of cohort studies of the natural history, clinical manifestations, and pathogenesis of HTLV-I and -II infections in persons referred from blood banks; and 3) examine the influence of these three retroviral infections on the natural history of opportunistic and tropical infections of the CNS in persons with retroviral infection. During our R21 planning grant, we discovered that HTLV-II infection was unexpectedly prevalent in selected populations in Lima (the capital) and two of the largest cities in the Amazon Jungle. In addition, we developed research collaborations with neurologists in Lima (the capital), Iquitos (Jungle), Arequipa (Andes Mountains), and Trujillo (Coast), and determined the most common manifestations of neuroAIDS in Iquitos and Arequipa; and through conferences and in-country training, provided research and human subjects training to over 200 experienced and new clinical investigators - many of them neurologists. Concurrently, UW-led HIV/AIDS-related research funding in Peru has grown to $5,000,000 per year from NIH and from private foundations, providing an outstanding foundation for further development of a CNS retroviral research program. The Collaborative Network for Tropical Neurologic Infectious Diseases established with researchers in nongovernmental and Ministry of Health institutions in Peru, with the U.S. Naval Medical Research Center Detachment (NMRCD) in Peru, and with Universities in Peru and the United States, will support future research on the clinical epidemiology of retroviral infections and their interactions with emerging tropical infections in Peru and eventually the Andean Region. In addition to continuing our investigations, we plan to continue training activities to address the research, education, training, and mentoring needs and opportunities related to CNS infection identified during the R21 planning grant.

描述（由申请方提供）：本RO 1申请的总体目标是在题为“秘鲁的中枢神经系统感染”的R21赠款期间启动的研究合作和调查的基础上，研究秘鲁神经系统逆转录病毒、机会性和热带感染的临床流行病学和发病机制;并继续在秘鲁选定城市的学术和研究机构中培养神经病学研究人员。这项赠款的具体目的是：（1）确定秘鲁四个最大城市中HTLV-II、HTLV-I、艾滋病毒感染以及同时感染这三种逆转录病毒病原体中的两种或两种以上的风险决定因素和临床表现; 2）建立国家HTLV感染临床研究参考中心，开展自然史、临床表现、和发病机制的HTLV-I和-II感染的人从血库;和3）检查这三种逆转录病毒感染的自然史的机会性和热带感染的CNS的逆转录病毒感染的人的影响。在我们的R21计划拨款期间，我们发现HTLV-II感染在利马（首都）和亚马逊丛林中两个最大城市的选定人群中出乎意料地普遍存在。此外，我们还与利马（首都）、伊基托斯（丛林）、阿雷基帕（安第斯山脉）和特鲁希略（海岸）的神经科医生开展了研究合作，确定了伊基托斯和阿雷基帕神经艾滋病的最常见表现;通过会议和国内培训，为200多名经验丰富的和新的临床研究人员提供了研究和人体受试者培训，其中许多人是神经科医生。与此同时，华盛顿大学领导的艾滋病毒/艾滋病相关的研究资金在秘鲁已经增长到每年从美国国立卫生研究院和私人基金会500万美元，提供了一个中枢神经系统逆转录病毒研究计划的进一步发展一个杰出的基础。与秘鲁的非政府机构和卫生部机构的研究人员、与秘鲁的美国海军医学研究中心分遣队以及与秘鲁和美国的大学建立了热带神经传染病合作网络，将支持今后对逆转录病毒感染的临床流行病学及其与秘鲁和最终安第斯地区新出现的热带感染的相互作用的研究地区除了继续我们的调查，我们计划继续培训活动，以解决研究，教育，培训和指导的需求和机会，在R21规划补助金期间确定的CNS感染。