HPV and HTLV Infection in Female Sex Workers in Peru

秘鲁女性性工作者的 HPV 和 HTLV 感染情况

• 批准号: 7236288
• 负责人: JOSEPH Raymond ZUNT
• 金额: $ 3.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-20 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7236288
• 关键词: Address; Biological Assay; Blood Banks; Caring; Central Nervous System Infections; Cervical; Characteristics; Cities; Clinic; Clinical; Clinical Research; Cohort Studies; Collaborations; Collection; Colposcopy; Communicable Diseases; Country; Cross-Sectional Studies; Development; Economics; Educational Background; Enrollment; Female; Future; Goals; Government; Grant; HIV Infections; HPV-High Risk; Health; Healthcare; High Prevalence; High Risk Woman; Human; Human Papillomavirus; Human T-lymphotropic virus 1; Human papilloma virus infection; Human papillomavirus 16; Image; Infection; Institution; Interview; Investigation; Knowledge; Longitudinal Studies; Malignant neoplasm of cervix uteri; Medical; Medical History; Medical Research; Mentors; Migrant Workers; Natural History; Nervous system structure; Neurologic; Neurologist; Nomads; Numbers; Oncogenic; Parents; Participant; Pathogenesis; Persons; Peru; Physiology; Policies; Polymerase Chain Reaction; Prevalence; Prevention; Prevention program; Prospective Studies; Prostitution; Public Health; Questionnaires; Rate; Research; Research Personnel; Retroviridae Infections; Risk; Risk Factors; Role; Sampling; Screening procedure; Serological; Sex Behavior; Sexually Transmitted Diseases; Social Workers; Spinal Cord Diseases; Structure; Swab; Symptoms; T-Lymphocyte; Testing; Training Activity; Training and Education; United States; United States National Institutes of Health; Universities; Vagina; Virus; Virus Diseases; Work; base; clinical epidemiology; cohort; condoms; demographics; design; digital; migration; nervous system infection; non-oncogenic; pathogen; prospective; sex; transmission process

DESCRIPTION (provided by applicant): We propose a United States-Peru collaboration to examine two common infections of major public health importance in female commercial sex workers (CSW): human papilloma virus (HPV) and human T-cell lymphotropic virus types 1 and 2 (HTLV). The research would be conducted in Peru at the U.S. Naval Medical Research Center Detachment and the Centra de Salud "Alberto Barton" del Callao in collaboration with Dr. Silvia Montano, as an extension of NIH grant #R01NS055627-01, entitled Retrovirus Infections of the Nervous System in Peru. CSW are at increased risk for sexually transmitted infections (STI), particularly those who do not receive routine medical care or who migrate for sex work from other Andean countries. Although both HPV and HTLV carry significant potential health consequences, such as cervical cancer and HTLV-l-associated myelopathy, no prevention programs currently exist in Peru. The aims of this study are to determine the prevalence and determinants of HPV and HTLV infections in CSW, to define the acquisition of HPV strain types in CSW initiating sex work, and examine the correlates of cervico-vaginal shedding of HPV and HTLV infections. The proposed study would address these aims through: 1) A cross-sectional study of migrant CSW receiving care at CSAB and via a mobile clinic, as well as an equal number of Peruvian CSW. Participants will receive a structured, face-to-face interview administered by a social worker regarding demographic, migration and economic characteristics, medical history, sexual behavior (including sexual networks and STI/HIV knowledge) and work practices. Cervical and serological samples will be obtained to test for HPV, HTLV, and other STI. Digital colposcopy will be performed to evaluate for cervical ectopy. 2) A prospective study of CSW who initiated sex work within the last two months. One hundred fifty participants will each receive quarterly HPV testing for one year. 3) A collection of 50 stored cervical brush samples will be analyzed for HPV and correlated with digital colposcopic findings and STI information. The proposed study would define HPV and HTLV prevalences among CSW in Peru, provide additional information regarding acquisition, shedding and transmission of HPV and HTLV infections in women at highest risk for these infections, and elucidate risk factors that could be used to develop prevention policies in Peru and other countries with women at high risk for these infections.

描述（由申请人提供）：我们提议美国与秘鲁合作，检查对女性商业性工作者 (CSW) 具有重大公共卫生重要性的两种常见感染：人乳头瘤病毒 (HPV) 和人类 T 细胞淋巴细胞病毒 1 型和 2 型 (HTLV)。该研究将在秘鲁的美国海军医学研究中心支队和 Centra de Salud "Alberto Barton" del Callao 与 Silvia Montano 博士合作进行，作为 NIH 拨款 #R01NS055627-01 的延伸，题为秘鲁神经系统的逆转录病毒感染。 CSW 感染性传播感染 (STI) 的风险增加，特别是那些没有接受常规医疗护理或从其他安第斯国家移居从事性工作的人。尽管 HPV 和 HTLV 都会带来严重的潜在健康后果，例如宫颈癌和 HTLV-1 相关脊髓病，但秘鲁目前尚无预防计划。本研究的目的是确定 CSW 中 HPV 和 HTLV 感染的患病率和决定因素，确定 CSW 开始性工作时获得 HPV 毒株类型，并检查宫颈阴道脱落 HPV 和 HTLV 感染的相关性。拟议的研究将通过以下方式实现这些目标： 1) 对在 CSAB 和通过流动诊所接受护理的移民 CSW 以及同等数量的秘鲁 CSW 进行横断面研究。参与者将接受由社会工作者进行的结构化、面对面的访谈，内容涉及人口、移民和经济特征、病史、性行为（包括性网络和性传播感染/艾滋病毒知识）和工作实践。将获取宫颈和血清学样本以检测 HPV、HTLV 和其他 STI。将进行数字阴道镜检查以评估宫颈异位。 2) 对最近两个月内开始从事性工作的 CSW 进行前瞻性研究。一百五十名参与者将每人接受为期一年的季度 HPV 检测。 3) 对 50 个储存的宫颈刷样本进行 HPV 分析，并与数字阴道镜检查结果和 STI 信息相关联。拟议的研究将确定秘鲁 CSW 中 HPV 和 HTLV 的患病率，提供有关高危女性 HPV 和 HTLV 感染的获得、排泄和传播的更多信息，并阐明可用于在秘鲁和其他有这些感染高危女性的国家制定预防政策的风险因素。