HPV and HTLV Infection in Female Sex Workers in Peru

秘鲁女性性工作者的 HPV 和 HTLV 感染情况

• 批准号: 7390408
• 负责人: JOSEPH Raymond ZUNT
• 金额: $ 3.03万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-20 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390408
• 关键词: Address; Biological Assay; Blood Banks; Caring; Central Nervous System Infections; Cervical; Characteristics; Cities; Clinic; Clinical; Clinical Research; Cohort Studies; Collaborations; Collection; Colposcopy; Communicable Diseases; Country; Cross-Sectional Studies; Development; Economics; Educational Background; Enrollment; Female; Future; Goals; Government; Grant; HIV Infections; HPV-High Risk; Health; Healthcare; High Prevalence; High Risk Woman; Human; Human Papillomavirus; Human T-lymphotropic virus 1; Human papilloma virus infection; Human papillomavirus 16; Image; Infection; Institution; Interview; Investigation; Knowledge; Longitudinal Studies; Malignant neoplasm of cervix uteri; Medical; Medical History; Medical Research; Mentors; Migrant Workers; Natural History; Nervous system structure; Neurologic; Neurologist; Nomads; Numbers; Oncogenic; Parents; Participant; Pathogenesis; Persons; Peru; Physiology; Policies; Polymerase Chain Reaction; Prevalence; Prevention; Prevention program; Prospective Studies; Prostitution; Public Health; Questionnaires; Rate; Research; Research Personnel; Retroviridae Infections; Risk; Risk Factors; Role; Sampling; Screening procedure; Serological; Sex Behavior; Sexually Transmitted Diseases; Social Workers; Spinal Cord Diseases; Structure; Swab; Symptoms; T-Lymphocyte; Testing; Training Activity; Training and Education; United States; United States National Institutes of Health; Universities; Vagina; Virus; Virus Diseases; Work; base; clinical epidemiology; cohort; condoms; demographics; design; digital; migration; nervous system infection; non-oncogenic; pathogen; prospective; sex; transmission process

We propose a United States-Peru collaboration to examine two common infections of major public health importance in female commercial sex workers (CSW): human papilloma virus (HPV) and human T-cell lymphotropic virus types 1 and 2 (HTLV). The research would be conducted in Peru at the U.S. Naval Medical Research Center Detachment and the Centra de Salud "Alberto Barton" del Callao in collaboration with Dr. Silvia Montano, as an extension of NIH grant #R01NS055627-01, entitled Retrovirus Infections of the Nervous System in Peru. CSW are at increased risk for sexually transmitted infections (STI), particularly those who do not receive routine medical care or who migrate for sex work from other Andean countries. Although both HPV and HTLV carry significant potential health consequences, such as cervical cancer and HTLV-l-associated myelopathy, no prevention programs currently exist in Peru. The aims of this study are to determine the prevalence and determinants of HPV and HTLV infections in CSW, to define the acquisition of HPV strain types in CSW initiating sex work, and examine the correlates of cervico-vaginal shedding of HPV and HTLV infections. The proposed study would address these aims through: 1) A cross-sectional study of migrant CSW receiving care at CSAB and via a mobile clinic, as well as an equal number of Peruvian CSW. Participants will receive a structured, face-to-face interview administered by a social worker regarding demographic, migration and economic characteristics, medical history, sexual behavior (including sexual networks and STI/HIV knowledge) and work practices. Cervical and serological samples will be obtained to test for HPV,HTLV, and other STI. Digital colposcopy will be performed to evaluate for cervical ectopy. 2) A prospective study of CSW who initiated sex work within the last two months. One hundred fifty participants will each receive quarterly HPV testing for one year. 3) A collection of 50 stored cervical brush samples will be analyzed for HPV and correlated with digital colposcopic findings and STI information. The proposed study would define HPV and HTLV prevalences among CSW in Peru, provide additional information regarding acquisition, shedding and transmission of HPV and HTLV infections in women at highest risk for these infections, and elucidate risk factors that could be used to develop prevention policies in Peru and other countries with women at high risk for these infections.

我们建议美国与秘鲁合作，审查两种主要公共卫生的常见感染