Repiratory Health and Community Asbestos Exposure

呼吸系统健康和社区石棉接触

• 批准号: 7278253
• 负责人: Bruce H. Alexander
• 金额: $ 35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278253
• 关键词: Repiratory; Health; Community; Asbestos; Exposure

Asbestos is a known causal factor for lung cancer, asbestosis, and mesothelioma. These associations are well established in occupationally exposed populations, however the risks at lower environmental exposures are not clear. The mission of the ATSDR includes developing the knowledge base related to understanding the effects of hazardous substances, like asbestos, on human health. The proposed research builds on previous worked funded by the ATSDR evaluating an asbestos contaminated environment. From 1938-1989 a densely populated urban residential neighborhood in Minneapolis MN experienced significant environmental asbestos exposure from processing asbestos contaminated vermiculite ore from Libby Montana at the Western Minerals/WR Grace facility. Waste rock from the processing plant was distributed widely around the neighborhood and children in the neighborhood frequently played on the piles of waste rock. The Minnesota Department of Health in cooperation with the ATSDR has established a roster of current and former residents of the neighborhood and have made initial estimates of exposure to this population. The long-term goal of this research effort is to determine the extent to which asbestos exposure from contaminated ore at the WM/WRG facility in Minneapolis resulted in adverse health consequences to workers and members of the surrounding community. The proposed research will focus on non-occupational exposure in the community. The following hypotheses will be addressed in this research. 1. Non-occupational exposure to asbestos contaminated vermiculite products and waste products is associated with increased prevalence of non-malignant asbestos related respiratory disease, specifically pleural abnormalities, in the members of the Northeast Minneapolis Community Vermiculite Investigation Cohort. 2. Exposure during childhood is more strongly related to onset of non-malignant respiratory disease. A sample of 600 of the identified residents will be selected based on probability of exposure. A respiratory screening protocol for detection of non-malignant respiratory abnormalities (radiographic and spirometry) consistent with asbestos exposure will establish prevalent asbestos related respiratory disease. The prevalence of these conditions will be compared on the basis of estimated asbestos exposure while controlling for potentially confounding covariates. Analyses will consider cumulative exposure and short, intense periods of exposure, with specific reference to exposure in childhood.

石棉是肺癌、石棉沉着病和间皮瘤的已知致病因素。这些协会 在职业接触人群中已得到充分确认，但在较低的环境接触下， 还不清楚美国毒物和疾病登记署的使命包括发展与了解有关的知识库 石棉等有害物质对人类健康的影响。拟议的研究建立在 以前的工作由ATSDR资助评估石棉污染的环境。 从1938年到1989年，明尼苏达州明尼阿波利斯市人口稠密的城市居民区经历了 处理石棉污染的蛭石矿石， Libby Montana在Western Minerals/WR Grace工厂。加工厂的废石 广泛分布在附近，附近的孩子们经常在成堆的 废石明尼苏达州卫生部与美国毒物与疾病登记署合作， 社区的现任和前任居民，并对暴露于此进行了初步估计 人口 这项研究工作的长期目标是确定石棉暴露的程度， 在明尼阿波利斯的WM/WRG工厂，受污染的矿石对工人的健康造成了不良后果 以及周围社区的成员拟议的研究将侧重于非职业性接触 在社区本研究将探讨以下假设。 1.非职业性接触石棉污染的蛭石产品和废物， 与非恶性石棉相关呼吸道疾病的患病率增加有关， 胸膜异常，在东北明尼阿波利斯社区蛭石调查的成员 队列。 2.儿童时期的接触与非恶性呼吸道疾病的发病有更强的相关性。 将根据暴露概率从已确定的居民中选出600名样本。呼吸 用于检测非恶性呼吸系统异常的筛查方案（放射学和肺功能测定） 与石棉暴露一致将确立普遍的石棉相关呼吸道疾病。的 将根据估计的石棉暴露情况比较这些情况的流行程度， 控制潜在的混杂协变量。分析将考虑累积暴露和短期， 强烈的接触时期，特别是儿童时期的接触。

项目成果

Radiographic evidence of nonoccupational asbestos exposure from processing Libby vermiculite in Minneapolis, Minnesota.

明尼苏达州明尼阿波利斯市利比蛭石加工过程中非职业性石棉暴露的放射线证据。

• DOI: 10.1289/ehp.1103529
• 发表时间: 2012
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Alexander,BruceH;Raleigh,KatherineK;Johnson,Jean;Mandel,JeffreyH;Adgate,JohnL;Ramachandran,Gurumurthy;Messing,RitaB;Eshenaur,Tannie;Williams,Allan
• 通讯作者: Williams,Allan