Towards a better understanding of work-aggravated asthma

更好地了解工作加重哮喘

• 批准号: 7275949
• 负责人: Catherine Lemiere
• 金额: $ 14.85万
• 依托单位: HOPITAL DU SACRE'-COEUR DE MONTREAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275949
• 关键词: Towards; better; understanding; work; aggravated

Work-aggravated asthma (WAA) is a frequent condition that has been so far overlooked. The broad objective of this program is to improve the diagnosis of WAA and to assess the socio-economic burden of this disease. In order to reach this objective, we propose the following specific aims. 1.To evaluate the proportion of subjects with WAA among the subjects who are referred yearly for possible work-related asthma in two clinics specialized in this field. 2.To compare the clinical, functional and inflammatory characteristics of subjects with WAA, occupational asthma (OA), and asthmatic subjects without WAA nor OA during periods at work and away from work. 3.To evaluate the risk of developing WAA or OA according to the exposure to specific agents at the workplace. 4.To compare the clinical functional and inflammatory outcome of subjects with WAA, OA and asthmatics without WAA nor OA over 2 years and establish prognostic factors for WAA 5.To assess the economic impact of WAA in terms of work disability and use of health resources. Methods. The first part of the study will be of crossover design, with periods of 2 weeks at work and 2 weeks away from work for 3 groups of 60 subjects: subjects with OA, subjects with WAA and asthmatics without WAA nor OA. At the end of each period of time, they will undergo a methacholine challenge and a sputum induction. Next, a specific inhalation challenge will be performed in subjects with work-related asthma to differentiate OA from WAA. Case-control studies will be performed in order to assess which type of occupational agents are likely to induce WAA. The second part of the study will consist in a cohort study with a two-year follow-up of the subjects with OA, WAA and asthmatics without OA not WAA. The subjects will be followed yearly for 2 years by spirometry, methacholine challenge and sputum induction. The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA.

工作加重哮喘(WAA)是一种到目前为止被忽视的常见疾病。《博大》 该计划的目的是提高对WAA的诊断，并评估社会经济 这种疾病的负担。为了实现这一目标，我们提出了以下具体目标。1.To 评估患有WAA的受试者在每年被转介的受试者中的比例 可能与工作有关的哮喘，在这一领域的两个专门诊所。2.为了比较临床， WAA、职业性哮喘和 哮喘受试者在工作和非工作期间既没有WAA也没有OA。3.评估 根据工作场所暴露于特定制剂的情况，罹患WAA或OA的风险。 4.比较WAA、OA和WAA受试者的临床功能和炎症结局 无WAA和OA的哮喘患者2年以上，并建立WAA 5的预后因素 评估WAA在工作残疾和卫生资源使用方面的经济影响。 方法：研究方法。研究的第一部分将是交叉设计，为期2周的工作和 3组60名受试者休息2周：OA受试者、WAA受试者和 无WAA或OA的哮喘患者。在每一段时间结束时，他们将经历一个 乙酰甲胆碱激发和痰诱导。接下来，一个特定的吸气挑战将是 在患有工作相关性哮喘的受试者中进行测试，以区分OA和WAA。病例对照研究 将进行评估，以评估哪种类型的职业诱因可能引发WAA。 这项研究的第二部分将包括一项队列研究，并对受试者进行为期两年的随访 有OA、WAA和哮喘的患者没有OA而不是WAA。受试者将每年跟踪调查两年。 通过肺活量测定、乙酰甲胆碱激发和诱导痰。哮喘的发生 病情恶化将被记录下来。WAA的经济影响将从工作的角度进行评估 残疾和卫生资源的使用，并与无骨性关节炎的骨性关节炎和哮喘相比，而不是WAA。