A Vervet Monkey(Cercopithecus Aethiops) Genetic Map

黑长尾猴（Cercopithecus Aethiops）遗传图谱

• 批准号: 7257180
• 负责人: NELSON B. FREIMER
• 金额: $ 28.83万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2009-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257180
• 关键词: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Abbreviations; Adolescent; Adult; Anatomy; Animal Model; Animals; Award; Bacterial Artificial Chromosomes; Bacterial Chromosomes; Behavior; Behavior Disorders; Behavioral; Biological; Biomedical Research; Brain; Brain region; Candidate Disease Gene; Caribbean natives; Caribbean region; Cell Line; Cercopithecus aethiops; Cercopithecus pygerythrus; Cercopithecus tantalus; Cerebrospinal Fluid; Chromosome Mapping; Chromosomes; Collaborations; Communicable Diseases; Communities; Complex; DNA Microarray Chip; DNA Microarray format; Data Analyses; Development; Disease; Dissection; European; Facility Construction Funding Category; Fluorescent in Situ Hybridization; Funding; Gene Expression; Gene Expression Profiling; Genes; Genetic; Genetic Markers; Genetic Polymorphism; Genome; Genomics; Goals; Grant; Human; Human Genome; Institutes; Internet; Investigation; Island; Letters; Libraries; Light; Macaca; Macaca mulatta; Magnetic Resonance Imaging; Maps; Microsatellite Repeats; Modeling; Molecular Profiling; Multiple Sclerosis; Mus; National Research Council; Parkinson Disease; Pediatric Hospitals; Phenotype; Physical Chromosome Mapping; Positron-Emission Tomography; Primates; Protocols documentation; Quebec; Range; Research; Research Institute; Research Personnel; Resources; SIV; Sampling; Sequence Tagged Sites; Single Nucleotide Polymorphism; Single Nucleotide Polymorphism Map; Site; Standards of Weights and Measures; Synteny; Tissue Microarray; Tissue Sample; Universities; Untranslated Regions; Variant; brain tissue; genetic analysis; genetic pedigree; genetic resource; human disease; innovation; member; nonhuman primate; research study; tool; trait; vervet

DESCRIPTION (provided by applicant): This is the renewal of a project that is developing an integrated genetic resource for investigations of complex traits in the vervet monkey (Cercopithecus aethiops), also known as the African Green monkey. Genetic investigation of complex traits will increasingly include a combination of traditional genetic mapping with identification of candidate genes through gene expression profiling. The renewal of this project will produce an integrated genomewide genetic reference map consisting of microsatellite and single nucleotide polymorphism (SNP) markers. The development of a microarray resource, covering a wide range of brain and non-brain tissues, at several points of development will enable investigations of gene expression in the vervet. Magnetic resonance imaging (MRI) studies will provide anatomic guidance for dissection of brain tissues for microarrays. The tools generated from this project will facilitate investigation of a wide range of human diseases and traits, including complex behaviors and infectious diseases. The utility of such studies derives from the fact that humans are much more similar to other primates than they are to other model organisms such as the mouse. The worldwide shortage of rhesus macaques for biomedical research has created a tremendous need for alternative non-human primate models. Vervets share many biological and behavioral similarities with macaques and are readily available to researchers. This project will further enhance the value of the vervet for biomedical research.

描述（由申请人提供）：这是一个项目的更新，该项目正在开发综合遗传资源，用于研究黑长尾猴（Cercopithecus aethiops）（也称为非洲绿猴）的复杂性状。复杂性状的遗传研究将越来越多地包括传统遗传图谱与通过基因表达谱鉴定候选基因的结合。该项目的更新将产生一个由微卫星和单核苷酸多态性（SNP）标记组成的集成全基因组遗传参考图谱。微阵列资源的开发覆盖广泛的脑和非脑组织，在多个开发点将能够研究长尾黑颚猴的基因表达。磁共振成像（MRI）研究将为微阵列脑组织解剖提供解剖学指导。该项目生成的工具将有助于研究广泛的人类疾病和特征，包括复杂的行为和传染病。此类研究的实用性源于这样一个事实：人类与其他灵长类动物的相似性远高于与小鼠等其他模式生物的相似性。全球范围内用于生物医学研究的恒河猴短缺，导致对替代非人类灵长类动物模型的巨大需求。长尾黑颚猴与猕猴有许多生物学和行为上的相似之处，研究人员很容易获得它们。该项目将进一步提升长尾黑颚猴的生物医学研究价值。