A Cognitive-Behavioral Intervention for Children with Autism Spectrum Disorders

针对自闭症谱系障碍儿童的认知行为干预

• 批准号: 7237038
• 负责人: Susan Williams White
• 金额: $ 12.97万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7237038
• 关键词: Address; Adherence; Adolescent; Advanced Development; Amendment; Anxiety; Applications Grants; Area; Award; Child; Clinical; Clinical Trials; Cognitive Therapy; Complement; Consultations; Data; Data Analyses; Development; Development Plans; Disease; Educational Curriculum; Environment; Evaluation; Evidence based treatment; Feasibility Studies; Foundations; Funding; Goals; Growth; Impairment; Instruction; Intervention; Intervention Studies; Investigation; Knowledge; Learning; Mainstreaming; Manuals; Measures; Mentored Research Scientist Development Award; Mentors; Methodology; Modeling; Personal Satisfaction; Phase; Pilot Projects; Population Heterogeneity; Positioning Attribute; Principal Investigator; Randomized Controlled Trials; Research; Research Activity; Research Design; Research Project Grants; Research Proposals; Research Training; Sampling; School-Age Population; Scientist; Social Interaction; Social skills development; Staging; Statistical Methods; Structure; Symptoms; Techniques; Testing; Training; Translating; Translations; Treatment outcome; autism spectrum disorder; base; career; childhood anxiety; design; disability; effectiveness research; effectiveness trial; experience; novel; peer; prevent; psychosocial; social; social skills; treatment program

DESCRIPTION (provided by candidate): I am applying for the Mentored Research Scientist Development Award (K01) program to promote my growth as an independent scientist. My goal with this award is to obtain the advanced training I need to develop an evidence-based treatment manual for a social skills intervention for children with autism spectrum disorders (ASD), and subsequently apply for an R01 to test these interventions in clinical trials. Children and adolescents with ASD who are cognitively 'high-functioning' frequently present with symptoms of anxiety, in addition to the core impairment in social interaction. This anxiety can interfere with their ability to integrate into mainstream academic environments, undermine their use of appropriate social skills in natural peer contexts, and impede their overall development. Thus, anxiety can be seen as compounding the social disability inherent in spectrum disorders, preventing otherwise able children from reaping the maximum benefit from interventions targeting social skill development. The K01 career development aims will allow me to gain additional instruction, mentoring and experience in: (1) assessment and treatment of ASD and childhood anxiety; (2) the design of psychosocial treatment manuals; (3) methods and statistical techniques appropriate for the design and conduct of randomized controlled trials of psychosocial interventions; and (4) responsible and ethical conduct of research. These training objectives relate directly to my research plan, the ultimate goal of which is to develop an evidence-based, efficacious treatment program for children with ASD that targets social skill development and anxiety reduction. The aims of this research are: (1) to develop an alpha version of a treatment manual that addresses social skill development and co-occurring anxiety in school-age children and adolescents with ASD; (2) to pilot strategies comprising the treatment manual with a small group (n=5) of children to refine intervention strategies and delivery; (3) to collect preliminary data on the short-term efficacy, as well as feasibility, of this structured manual-based treatment in a sample (n=24) of children with ASD complicated by anxiety; and (4) to develop a grant application to conduct a larger scale efficacy study of the treatment curriculum. Through this training and research plan, I will be well-positioned to carry out independent investigations designed to translate an empirical understanding of anxiety and social disability in children with high-functioning ASD into novel treatment approaches.

描述（由候选人提供）：我正在申请指导研究科学家发展奖（K01）计划，以促进我作为一名独立科学家的成长。我获得该奖项的目标是获得所需的高级培训，以制定针对自闭症谱系障碍 (ASD) 儿童社交技能干预的循证治疗手册，并随后申请 R01 在临床试验中测试这些干预措施。认知能力“高功能”的患有自闭症谱系障碍的儿童和青少年除了社交互动的核心障碍外，还经常出现焦虑症状。这种焦虑会干扰他们融入主流学术环境的能力，破坏他们在自然同伴环境中使用适当的社交技能，并阻碍他们的整体发展。因此，焦虑可以被视为加剧了谱系障碍固有的社交障碍，阻碍了原本有能力的儿童从针对社交技能发展的干预措施中获得最大的益处。 K01 职业发展目标将使我能够在以下方面获得额外的指导、指导和经验：(1) 自闭症谱系障碍 (ASD) 和儿童焦虑症的评估和治疗； （二）心理社会治疗手册的设计； (3) 适合设计和进行心理社会干预随机对照试验的方法和统计技术； (4) 负责任且符合道德的研究行为。这些培训目标与我的研究计划直接相关，我的研究计划的最终目标是为患有自闭症谱系障碍的儿童制定一个基于证据的、有效的治疗计划，以发展社交技能和减少焦虑为目标。本研究的目的是：(1) 开发治疗手册的 alpha 版本，以解决患有自闭症谱系障碍 (ASD) 的学龄儿童和青少年的社交技能发展和同时发生的焦虑； (2) 对一小群儿童（n = 5）进行包括治疗手册在内的试点策略，以完善干预策略和实施； (3) 收集关于这种结构化的手动治疗在 ASD 并发焦虑儿童样本（n=24）中的短期疗效和可行性的初步数据； (4) 制定拨款申请，以对治疗课程进行更大规模的功效研究。通过这项培训和研究计划，我将能够开展独立调查，旨在将对高功能自闭症谱系障碍儿童的焦虑和社交障碍的实证理解转化为新的治疗方法。