Hemispheric Lateralization and Interlimb Transfer of Motor Learning

运动学习的半球侧化和肢体间迁移

• 批准号: 7197589
• 负责人: Jinsung Wang
• 金额: $ 12.67万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7197589
• 关键词: Age; Biomechanics; Brain Injuries; Cerebral hemisphere; Classification; Clinical; Communication; Condition; Depth; Development Plans; Educational workshop; Hand; Image; Investigation; Ipsilateral; Lateral; Lead; Left; Lesion; Limb structure; Literature; Mentored Research Scientist Development Award; Mentors; Motor; Movement; Nature; Nervous System Trauma; Patients; Pattern; Performance; Positioning Attribute; Process; Rehabilitation Research; Rehabilitation therapy; Research; Residual state; Role; Stroke; System; Testing; Upper arm; Work; base; career; experience; hemiparesis; hemiparetic stroke; improved; knowledge base; motor control; motor learning; neuromechanism; neuroregulation; novel; programs; rehabilitation strategy; relating to nervous system; skills; stem; visual motor; young adult

DESCRIPTION (provided by applicant): The proposed Mentored Research Scientist Development Award aims to prepare the candidate for a productive independent research career directed at examining the neural mechanisms underlying hemispheric lateralization and interlimb transfer of motor learning. Central to this proposal is expanding the candidate's knowledge base and research skills necessary for clinical rehabilitation research. The knowledge base and skills obtained through this career development plan will enable the candidate to develop a rehabilitation research program that is aimed at investigating neural control and motor learning in patients with neurological damage. The objective of the research plan is to characterize the neural mechanisms that underlie hemispheric lateralization and interlimb transfer of motor learning. The proposal builds on previous findings obtained by the candidate, which showed that the dominant and nondominant arm controllers are differentially proficient in controlling movement trajectory and final limb position, respectively, and that interlimb transfer of motor learning depends on the proficiency of these controllers. These findings lead to a hypothesis that such lateral advantages stem from left and right hemisphere specializations for different features of control. The candidate now proposes to test this hypothesis (1) by investigating interlimb transfer of dynamic adaptation in healthy young adults, and (2) by examining reaching movement in the ipsilesional arm of stroke patients with hemiparesis. The educational plan will focus on three basic objectives (1) obtaining a knowledge base and skills necessary for clinical rehabilitation research and neural imaging research (2) furthering the candidate's skills in computational and biomechanical analysis of movement; and (3) furthering the candidate's communication and mentoring skills. The candidate will develop these skills through the proposed course work, seminars and workshops, and research experience that incorporates computational and biomechanical analyses of movement into a clinical rehabilitation related project with the possibility of significant findings. Findings from the proposed research will directly contribute to an understanding of specialized roles of each brain hemisphere in movement control, as well as functional deficits in ipsilesional arm movements of stroke patients with unilateral brain damage. These findings may prove valuable for developing more specific and effective rehabilitation strategies for patients with neurological damage.

描述（由申请人提供）：拟议的指导研究科学家发展奖旨在为候选人准备一个富有成效的独立研究生涯，旨在研究运动学习的大脑半球偏侧化和肢体间转移的神经机制。这项建议的核心是扩大候选人的知识基础和临床康复研究所需的研究技能。通过这个职业发展计划获得的知识基础和技能将使候选人能够开发一个康复研究计划，旨在调查神经损伤患者的神经控制和运动学习。本研究计划的目的是描述运动学习的大脑半球偏侧化和肢体间转移的神经机制。该提案建立在候选人之前获得的研究结果的基础上，该研究结果表明，优势臂和非优势臂控制器分别在控制运动轨迹和最终肢体位置方面具有不同的熟练程度，并且运动学习的肢体间转移取决于这些控制器的熟练程度。这些发现导致了一个假设，这种横向优势源于左右半球对不同控制功能的专门化。候选人现在提出通过研究健康年轻人的动态适应的肢体间转移和（2）通过检查中风偏瘫患者同侧臂的伸展运动来验证这一假设。 教育计划将侧重于三个基本目标（1）获得临床康复研究和神经成像研究所需的知识基础和技能（2）促进候选人在运动的计算和生物力学分析方面的技能;（3）促进候选人的沟通和指导技能。候选人将通过拟议的课程工作，研讨会和讲习班，以及将运动的计算和生物力学分析纳入临床康复相关项目的研究经验来发展这些技能，并可能有重大发现。拟议研究的结果将直接有助于了解每个大脑半球在运动控制中的专门作用，以及单侧脑损伤中风患者同侧手臂运动的功能缺陷。这些发现可能对为神经损伤患者制定更具体、更有效的康复策略有价值。