Hemispheric Lateralization and Interlimb Transfer of Motor Learning

运动学习的半球侧化和肢体间迁移

• 批准号: 7759589
• 负责人: Jinsung Wang
• 金额: $ 13.03万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7759589
• 关键词: Age; Biomechanics; Brain Injuries; Cerebral hemisphere; Clinical; Communication; Development Plans; Educational workshop; Hand; Image; Investigation; Ipsilateral; Lateral; Lead; Left; Lesion; Limb structure; Literature; Mentored Research Scientist Development Award; Mentors; Motor; Movement; Nature; Nervous System Trauma; Patients; Pattern; Performance; Positioning Attribute; Process; Rehabilitation Research; Rehabilitation therapy; Research; Residual state; Role; Stroke; System; Testing; Work; arm; base; career; career development; experience; hemiparesis; hemiparetic stroke; improved; knowledge base; motor control; motor learning; neuromechanism; neuroregulation; novel; programs; rehabilitation strategy; relating to nervous system; skills; stem; visual motor; young adult

DESCRIPTION (provided by applicant): The proposed Mentored Research Scientist Development Award aims to prepare the candidate for a productive independent research career directed at examining the neural mechanisms underlying hemispheric lateralization and interlimb transfer of motor learning. Central to this proposal is expanding the candidate's knowledge base and research skills necessary for clinical rehabilitation research. The knowledge base and skills obtained through this career development plan will enable the candidate to develop a rehabilitation research program that is aimed at investigating neural control and motor learning in patients with neurological damage. The objective of the research plan is to characterize the neural mechanisms that underlie hemispheric lateralization and interlimb transfer of motor learning. The proposal builds on previous findings obtained by the candidate, which showed that the dominant and nondominant arm controllers are differentially proficient in controlling movement trajectory and final limb position, respectively, and that interlimb transfer of motor learning depends on the proficiency of these controllers. These findings lead to a hypothesis that such lateral advantages stem from left and right hemisphere specializations for different features of control. The candidate now proposes to test this hypothesis (1) by investigating interlimb transfer of dynamic adaptation in healthy young adults, and (2) by examining reaching movement in the ipsilesional arm of stroke patients with hemiparesis. The educational plan will focus on three basic objectives (1) obtaining a knowledge base and skills necessary for clinical rehabilitation research and neural imaging research (2) furthering the candidate's skills in computational and biomechanical analysis of movement; and (3) furthering the candidate's communication and mentoring skills. The candidate will develop these skills through the proposed course work, seminars and workshops, and research experience that incorporates computational and biomechanical analyses of movement into a clinical rehabilitation related project with the possibility of significant findings. Findings from the proposed research will directly contribute to an understanding of specialized roles of each brain hemisphere in movement control, as well as functional deficits in ipsilesional arm movements of stroke patients with unilateral brain damage. These findings may prove valuable for developing more specific and effective rehabilitation strategies for patients with neurological damage.

描述(由申请者提供)：建议的指导式研究科学家发展奖旨在为候选人进行富有成效的独立研究生涯做准备，旨在研究运动学习的大脑半球偏侧化和肢体间转移的神经机制。这项建议的核心是扩大候选人的知识库和临床康复研究所需的研究技能。通过这一职业发展计划获得的知识基础和技能将使应聘者能够开发一项康复研究计划，旨在调查神经损伤患者的神经控制和运动学习。该研究计划的目标是描述大脑半球偏侧化和肢体间运动学习迁移的神经机制。该建议建立在候选人之前获得的研究结果的基础上，该发现表明，优势臂控制器和非优势臂控制器在控制运动轨迹和最终肢体位置方面分别具有不同的熟练程度，运动学习的肢体间迁移取决于这些控制器的熟练程度。这些发现导致了一种假设，即这种横向优势源于左右半球对不同控制特征的专门化。候选人现在建议(1)通过研究健康年轻人的动态适应的肢体间转移来检验这一假设，以及(2)通过检测中风偏瘫患者偏瘫手臂的伸展运动来检验这一假说。教育计划将集中于三个基本目标(1)获得临床康复研究和神经成像研究所需的知识和技能(2)进一步提高候选人在运动计算和生物力学分析方面的技能；以及(3)进一步提高候选人的沟通和指导技能。候选人将通过拟议的课程工作、研讨会和研讨会以及研究经验来发展这些技能，这些研究经验将运动的计算和生物力学分析结合到与临床康复相关的项目中，并有可能获得重大发现。这项拟议研究的结果将直接有助于了解每个大脑半球在运动控制中的特殊作用，以及中风患者单侧脑损伤的自发性手臂运动的功能缺陷。这些发现可能被证明对开发更具体和有效的神经损伤患者的康复策略有价值。