Metal emissions from traffic pollution as a risk factor for osteoporosis

交通污染造成的金属排放是骨质疏松症的危险因素

• 批准号: 2899556
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2899556
• 关键词: Metal; emissions; traffic; pollution; risk

The overall aim of my PhD is to identify the mechanisms linking exogenous heavy metals from traffic-related air pollution to the predisposition to osteoporotic fragility fractures. This thesis has two main objectives: first, to develop and perform analyses on in vitro micro-CT images of bone fragments exposed to particulate pollution in a bioreactor to better inform thebiological mechanisms that can be used to develop improved algorithms of the remodelling process. The second aim is to use the algorithm to develop a physiological finite element (FE)simulation of a long-time span of the same bones inside the bioreactor in order to determine what the long-term effects of exposure would have been.

我的博士学位的总体目标是确定交通相关的空气污染的外源性重金属的易感性，以减少脆性骨折的机制。本论文有两个主要目标：第一，开发和执行分析的体外micro-CT图像的骨碎片暴露于颗粒污染的生物反应器，以更好地告知thebiological机制，可用于开发改进算法的重塑过程。第二个目标是使用该算法开发生物反应器内相同骨骼的长时间跨度的生理有限元（FE）模拟，以确定暴露的长期影响。