Multidisciplinary Biodefense Training Program

描述（由申请人提供）：这是一项新的申请，旨在建立一个生物防御培训计划，以培养博士前学员，帮助国家应对生物恐怖威胁的新挑战。该计划有19名教师，来自塔夫茨大学医学院和新英格兰医疗中心医院的Sackler生物医学研究生院的遗传学，免疫学和分子微生物学研究生课程。 重点培训的致病机理和微生物的遗传学是相关的生物防御将与培训在理解这些微生物的宿主反应。 通过这种方式，我们的学员将准备攻击生物防御相关的问题，深入了解病原体-宿主相互作用。 新开发的课程整合了遗传学，免疫学和分子微生物学课程。 此外，新开发的课程介绍了最有效的生物制剂的发病机制，以及与生物恐怖主义和生物战有关的科学，医学，社会和政治问题。 生物防御培训方案还与新设想的传染病免疫遗传学研究中心（SCIID）建立了联系，该中心是一个侧重于传染病遗传、免疫和微生物方面的组织。 SCIID将位于新建的Jaharis家庭中心，并将为我们的学员提供智力和身体的家园。该中心还将为学生提供在BL-3级遏制工作的机会，使用基因阵列技术研究宿主和病原体基因表达，并获得BL-3级细胞分选。 就读于遗传学，免疫学或分子微生物学研究生课程的博士前学生可以在研究生院的第一年后申请进入生物防御培训计划。 选择我们的计划将基于在实验室轮换和课程的第一年，生物防御培训计划教师作为论文导师之一的选择，并致力于工作相关的生物防御问题的论文主题的高成就。三名学生将被选为两年的支持（六个职位）。我们的计划的好处包括：1）学生已经注册谁是生物防御相关问题的工作; 2）一个经验丰富的培训教师到位; 3）一个强大的课程已经存在;和4）SCIID的发展显示机构承诺这个程序，并提供了一个优秀的培训环境。 参与教师：培训教师19人，其中教授11人，副教授3人，助教5人. 培训教员中有六名妇女。 14名培训教师在塔夫茨大学有主要任命，5名培训教师位于新英格兰医疗中心医院。主要研究领域包括遗传学、免疫学和分子微生物学。

DESCRIPTION (provided by applicant): This is a new application to establish a biodefense training program to produce predoctoral trainees who will aid the nation in combating the new challenges of the bioterror threat. The program has a faculty of 19, drawn from the Genetics, Immunology and Molecular Microbiology Graduate Programs of the Sackler School of Graduate Biomedical Sciences of Tufts University School of Medicine and New England Medical Center Hospitals. Focused training in the pathogenesis and genetics of microorganisms that are relevant to biodefense will be integrated with training in understanding host responses to these microorganisms. In this way, our trainees will be prepared to attack biodefense-related problems with an in-depth understanding of pathogen-host interaction. A newly developed curriculum integrates courses offered by Genetics, Immunology and Molecular Microbiology. In addition, a newly-developed course presents the pathogenesis of the most potent biological agents together with scientific, medical, social, and political issues relevant to bioterrorism and biowarfare. The Biodefense Training Program also interfaces with the newly conceived Study Center for the Immunogenetics of Infectious Disease (SCIID), an organization that focuses on genetic, immunological and microbiological aspects of infectious disease. The SCIID will be located in the newly constructed Jaharis Family Center, and will provide an intellectual and physical home for our trainees. This Center will also give students the opportunity to work at the BL-3 level of containment, use gene array technology to study host and pathogen gene expression, and have access to BL-3-level cell sorting. Predoctoral students enrolled in the Genetics, Immunology or Molecular Microbiology Graduate Programs may apply to enter the Biodefense Training Program after their first year of graduate school. Selection for our program will be based on high achievement in lab rotations and coursework during the first year, selection of one of the Biodefense Training Program faculty as a thesis mentor, and commitment to work on a dissertation topic relevant to biodefense concerns. Three students will be selected for two years of support (six positions). Benefits of our program include: 1) students are already enrolled who are working on biodefense related issues; 2) a highly experienced training faculty is in place; 3) a strong curriculum already exists; and 4) development of the SCIID shows institutional commitment to this program and provides an outstanding training setting. PARTICIPATING FACULTY: The 19 training faculty include 11 professors, 3 associate professors, and 5 assistant professors. Six of the training faculty are women. Fourteen of the training faculty have primary appointments at Tufts University and five training faculty are located at the New England Medical Center Hospital. The primary areas of research include genetics, immunology and molecular microbiology.