TNPRC Regional Biocontainment Laboratory Upgrade for Capacity Building

TNPRC 区域生物防护实验室升级以进行能力建设

• 批准号: 10632933
• 负责人: JAY RAPPAPORT
• 金额: $ 344.3万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632933
• 关键词: 2019-nCoV; Appointment; COVID-19; COVID-19 pandemic; Caring; Centers for Disease Control and Prevention (U.S.); Communicable Diseases; Communities; Containment; Decontamination; Detection; Development; Emerging Communicable Diseases; Ensure; Epidemic; Equipment; Faculty; Flow Cytometry; Funding; Future; Goals; Growth; Health; Human; IACUC; Immunology; Infrastructure; Joints; Laboratories; Liquid substance; Mission; Modernization; Outcome; Power Sources; Primates; Public Health; Pulmonology; Regulation; Research; Research Activity; Research Personnel; Resources; Safety; Series; Services; Site; System; Talents; Therapeutic; Tissue Sample; Toxin; Tropical Medicine; United States National Institutes of Health; Update; Vaccines; Validation; Work; animal model development; animal resource; biodefense; diagnostic assay; emerging pathogen; exhaust; improved; medical schools; multidisciplinary; nonhuman primate; novel diagnostics; operation; pathogen; population health; product development; programs; quality assurance; repaired; research clinical testing; response; restoration; risk minimization; virology; wasting

The Tulane National Primate Research Center (TNPRC) is one of seven NPRCs that serve as local, regional, and national resources to conduct nonhuman primate (NHP) research with the goal of improving human health. The TNPRC maintains a focus on infectious diseases and is the only NPRC with a Regional Biocontainment Laboratory (RBL) at biosafety level 3 (BSL-3) for the study of high consequence pathogens, including select agents and toxins, and biodefense research. In recent years, and particularly with the onset of the COVID-19 pandemic, the TNPRC RBL has seen massive growth in emerging pathogen and biodefense work. The facility is in critical need of additional upgrades, modernization projects, and laboratory enhancements, both to support the rapidly growing demand for BSL-3 research and to ensure a robust and efficient containment system that is vital for protecting workers, the Center, and the surrounding community. The purpose of the proposed project is to strategically enhance research capabilities by introducing new equipment space within the TNPRC RBL to accommodate our growing BSL-3 research portfolio. To this end, we propose the following specific aims: Aim 1. Implement a series of improvements to the TNPRC RBL infrastructure, including replacement of damaged phoenix valves, restoration of DeCon Tank capabilities, upgrade of uninterruptible power supply (UPS) systems, and update of the boiler burner which can no longer be repaired due to the discontinued manufacturing of replacement parts. Aim 2. Upgrade equipment to expand clinical evaluation capabilities in the BSL-3. Aim 3. Incorporate functional equipment pieces to support BSL-3 research activities, enabling and expanding the capacity of the RBL to conduct numerous research capabilities where regulations are extensive to be able to take them into non-select agent space. The ability to respond to potential epidemics rapidly and efficiently by developing and applying novel diagnostic assays, therapeutics, and vaccines is critical to minimize risk and negative population health outcomes. The TNPRC is uniquely capable of quickly responding to emerging threats, from detection through product development, due to our status as the only NPRC with an on-site BSL-3 Regional Biocontainment Laboratory, unique Quality Assurance Program, and extensive support of on-site core services. By mid-February 2020, we had already established a COVID-19 research program, with Centers for Disease Control & Prevention (CDC)-permitted acquisition of SARS-CoV-2 stock and IACUC approval of our animal model development studies. The TNPRC has a highly talented group of investigators with nationally recognized expertise in biocontainment, virology, immunology, pulmonology, vaccines, and veterinary care. Our faculty, with joint appointments in Departments across the Tulane Schools of Medicine and Public Health & Tropical Medicine, are involved in the development of multiple collaborative planning efforts locally, regionally, and nationally, including a Tulane-funded multidisciplinary Center of Excellence for Emerging/Re- emerging Infectious Disease (CEERID) and an application for federal funding of a Center of Excellence for Emerging Pathogens. Evidence of the impact of our collaborative research efforts is demonstrated by the allocation of close to 75% of animal resources to affiliate investigators and distribution of nearly 90,000 tissue samples to 461 NIH-funded collaborators in a recent 5-year period. This broad network of investigators will rely on the proposed project to enhance the capability and quality of our work and mission in support of studies directed toward the safe and rapid response to high consequence pathogens.

杜兰国家灵长类研究中心(TNPRC)是当地七个国家灵长类研究中心之一， 区域和国家资源，用于进行非人类灵长类(NHP)研究，目标是 改善人类健康。TNPRC继续关注传染病，是唯一的NPRC 与生物安全3级(BSL-3)的区域生物遏制实验室(RBL)合作研究高 后果病原体，包括选定的制剂和毒素，以及生物防御研究。在最近 多年来，特别是随着新冠肺炎大流行的开始，TNPRC RBL经历了大量的 新出现的病原体和生物防御工作的增长。该设施迫切需要更多的 升级、现代化项目和实验室增强，两者都是为了支持快速增长的 对BSL-3研究的需求，并确保一个强大而高效的遏制系统，这对 保护工人、中心和周围社区。拟议项目的目的 是在战略上增强研究能力，通过在 TNPRC RBL以适应我们不断增长的BSL-3研究组合。为此，我们建议 以下是具体目标： 目标1.对TNPRC RBL基础设施进行一系列改进，包括更换 修复损坏的菲尼克斯阀门，恢复十开水箱的能力，升级不间断电源 供应(UPS)系统和更新锅炉燃烧器，因为 停止生产替换部件。 目的2.升级设备以扩大BSL-3的临床评估能力。 目标3.纳入功能设备部件以支持BSL-3研究活动，使 扩大RBL的能力，以便在有法规的地方进行大量研究 范围广泛，能够将他们带入非选定的代理领域。 通过开发和应用新技术，快速有效地应对潜在流行病的能力 诊断分析、治疗和疫苗对于将风险和阴性人群降至最低至关重要。 健康结果。TNPRC是唯一能够快速应对新出现的威胁的机构，来自 通过产品开发进行检测，因为我们是唯一拥有现场BSL-3的NPRC 区域生物遏制实验室，独特的质量保证计划，以及广泛的支持 现场核心服务。到2020年2月中旬，我们已经成立了新冠肺炎研究中心 与疾病控制和预防中心(CDC)合作的计划-允许获取SARS-CoV-2 STOCK和IACUC批准我们的动物模型开发研究。TNPRC有很高的 具有国家公认的生物遏制、病毒学、 免疫学、肺病学、疫苗和兽医护理。我们的教职员工，在 杜兰医学院和公共卫生与热带医学院的系是 参与制定多项本地、区域和区域协作规划工作 在全国范围内，包括杜兰大学资助的新兴/重新崛起多学科英才中心 新发传染病(CEERID)和一个联邦资金中心的申请 新兴病原体的卓越表现。我们合作研究工作的影响的证据是 将近75%的动物资源分配给附属调查人员和 在最近5年内向461名NIH资助的合作者分发了近90,000个组织样本 句号。这一广泛的调查网络将依赖于拟议的项目 增强能力 我们的工作和使命是支持针对安全和快速反应的研究 到严重后果的病原体。