Training Program in Free Radical and Radiation Biology

自由基和放射生物学培训计划

• 批准号: 7194150
• 负责人: LARRY OBERLEY
• 金额: $ 22.3万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7194150
• 关键词: Free Radicals; Radiobiology; Training Programs

DESCRIPTION (provided by applicant): The University of Iowa Training Program in Free Radical and Radiation Biology is oriented around six key goals for education in preparation of trainees for a career in free radical and radiation biology: 1) To impart a fundamental understanding of the subject matter of radiation biology, free radical biology, and cancer biology; 2) To provide trainees with the opportunity to achieve proficiency in the radiation biology, free radical biology, and molecular oncology disciplines leading to successful careers in cancer research; 3) To structure research experience for trainees that includes the development of a research proposal, execution of a research project, and evaluation of these results for submission in peer-reviewed publications; 4) To offer trainees experience in learning the necessary knowledge and skills to do collaborative research with faculty in clinical and basic science departments; 5) To provide trainees with critical knowledge of the structure of science and essential skills in both oral and written scientific communication; and 6) To encourage trainees to implement innovative approaches in a "real world" environment to test explicit hypotheses about the mechanisms and consequences of radiobiological and free radical phenomena. With this application, we are proposing to continue to support three predoctoral trainees per year and also to phase in the additional support of postdoctoral trainees. We propose to support one postdoctoral trainee in the first year, two in the second, and three in years 3-5. We have an internationally recognized faculty with consistent involvement in nationally recognized radiobiology and free radical research projects, program projects, individual research awards, and The University of Iowa Cancer Center. We propose to have 10 mentors in the Training Program, 4 from the Department of Radiation Oncology and one each from the Departments of Internal Medicine, Pathology, Surgery, Anatomy and Cell Biology, Exercise Science, and Chemistry. Education for our trainees involves one-on-one mentoring by faculty members, working on cancer related nationally recognized research projects, presenting work and receiving feedback at national meetings, plus formal course work offered by the department and the other excellent resources at The University of Iowa. Formal coursework includes classes in radiation, free radical, and cancer biology. The faculty, fellows, and students form a critical mass for providing a provocative environment for seminars, journal clubs, and informal discussion. Research being pursued goes from the bench top to the clinic. Communication, both verbal and written, is stressed in the Training Program, so that the science that is done can be communicated to other scientists. We believe this Training Program has all the ingredients necessary to produce the needed high quality scientists in free radical and radiation biology who will work in cancer research.

描述（由申请人提供）：爱荷华州大学自由基和辐射生物学培训计划围绕六个关键目标进行教育，为学员在自由基和辐射生物学领域的职业生涯做好准备： 1)传授辐射生物学、自由基生物学和癌症生物学的基本知识; 2)为学员提供机会，以达到熟练的放射生物学，自由基生物学，和分子肿瘤学学科导致成功的职业生涯中的癌症研究; 3)为受训人员提供研究经验，包括制定研究建议、执行研究项目以及评估这些结果，以便在同行评审的出版物中提交; 4)为学员提供学习必要知识和技能的经验，以便与临床和基础科学部门的教师进行合作研究; 5)为学员提供科学结构的关键知识和口头和书面科学交流的基本技能;以及 6)鼓励受训人员在“真实的世界”环境中采用创新办法，以检验关于放射生物学和自由基现象的机制和后果的明确假设。 通过这项申请，我们建议继续每年支持三名博士前学员，并逐步增加对博士后学员的支持。 我们建议在第一年支持一名博士后实习生，第二年支持两名，第三年至第五年支持三名。 我们有一个国际公认的教师在国家认可的放射生物学和自由基研究项目，计划项目，个人研究奖，和爱荷华州癌症中心的大学一贯参与。 我们建议在培训计划中有10名导师，其中4名来自放射肿瘤学系，1名来自内科，病理学，外科，解剖学和细胞生物学，运动科学和化学。 我们的学员的教育涉及教师一对一的指导，从事与癌症相关的国家认可的研究项目，在全国会议上展示工作并接受反馈，加上正式的课程工作由部门提供和其他优秀的资源在爱荷华大学爱荷华州。 正式的课程包括辐射、自由基和癌症生物学。 教师，研究员和学生形成了一个临界质量，为研讨会，期刊俱乐部和非正式讨论提供了一个挑衅性的环境。 正在进行的研究从实验室到诊所。 培训计划强调口头和书面沟通，以便将所做的科学工作传达给其他科学家。 我们相信，这个培训计划具有培养自由基和辐射生物学所需的高质量科学家所需的所有要素，他们将在癌症研究中工作。