Oxidative Stress and Metabolism Research Cluster

氧化应激和代谢研究集群

• 批准号: 7359471
• 负责人: LARRY OBERLEY
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7359471
• 关键词: Advisory Committees; Development; Environmental Health; Faculty; Gene Expression; Genetic; Genome; Genomics; Genotype; Goals; Health Sciences; Human; Individual; Investigation; Knowledge; Laboratories; Leadership; Mentors; Metabolism; Oxidative Stress; Population; Proteomics; Publications; Research; Research Personnel; Resources; Series; Techniques; base; experience; genome sequencing; health science research; innovation; programs; size

Goals and Aims Our goal is to establish a new Research Cluster to serve as a hub of intellectual activity to build innovative environmental genomics into the EHSRC research portfolio and to serve as a resource that will facilitate the transfer of knowledge, strategy and techniques to junior investigators beginning new programs and established investigators ready to incorporate genomics into existing EHSRC investigations. We will take advantage of successful efforts already in place on our campus with investigators who have a long standing experience of genomics/genetics as well as the capability to provide leadership and guidance. The primary goal in building an environmental genomics research capability is to take advantage of the developments in both laboratory techniques and analytical advances to provide a setting in which investigators can add genetics/genomics to new or ongoing research programs. The initial publication of human genome sequence in 2000 has been followed by a series of ever more startling developments that provide opportunities for individual and population based studies incorporating genetics on a scale that exceeds even the most positive views of just a few years ago. DMA sequencing capabilities, gene expression analysis, proteomics and genotype analysis are now all affordable on a genome scale to even modest size laboratory groups.

目标和目的 我们的目标是建立一个新的研究集群，作为智力活动的中心，建立创新的 环境基因组学纳入EHSRC研究组合，并作为一种资源，将促进 向初级调查人员传授知识、战略和技术，开始新的项目和 成熟的调查人员准备将基因组学纳入现有的EHSRC调查。我们会带上 利用我们校园中已有的成功努力与长期从事调查工作的人员进行合作 具备基因组学/遗传学方面的经验，以及提供领导和指导的能力。 建设环境基因组学研究能力的主要目标是利用 实验室技术和分析进步的发展，以提供一个 研究人员可以将遗传学/基因组学添加到新的或正在进行的研究项目中。最初出版的 2000年的人类基因组序列之后，出现了一系列更令人震惊的发展 为以个体和群体为基础的研究提供机会，将遗传学纳入到 甚至超过了几年前最积极的观点。DNA测序功能，基因 表达分析、蛋白质组学和基因分析现在在基因组规模上都是负担得起的 中等规模的实验室小组。