PROGRAM IN MOLECULAR AND COMPUTATIONAL BIOPHYSICS

分子和计算生物物理学项目

• 批准号: 7249510
• 负责人: DAVID E. DRAPER
• 金额: $ 74.13万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249510
• 关键词: Biophysics; Molecular; programs

DESCRIPTION (provided by applicant): The Program in Molecular and Computational Biophysics is seeking to renew its training grant. The Jenkins Department of Biophysics (Arts & Sciences, Homewood campus) and the Department of Biophysics and Biophysical Chemistry (School of Medicine, East Baltimore campus) form the core of the program with respect to administration and curriculum; 44 faculty, drawn from 15 departments and about evenly divided between the two campuses, participate in training activities. Students freely move between campuses and laboratories for course work, rotations, and thesis research. The training faculty roster has grown to include more faculty working in areas of NMR, X-ray crystallography, membrane proteins, computational biophysics, and biochemical transformations. The 44 participating laboratories have a strong sense of community engendered by activities such as an annual retreat, a monthly evening Biophysical Discussion, and the biennial Johns Hopkins Folding Meeting. Faculty also have access to shared instrumentation facilities for X-ray crystallography, ultracentrifugation, and high field NMR. In the first year, students take four core courses specifically designed for the program: Physical Chemistry of Biological Macromolecules; Proteins and Nucleic Acids; Methods in Molecular Biophysics; and Computer Modeling of Biological Macromolecules; the courses have recently been revamped to increase literature readings, classroom time devoted to discussion, and computer programming exercises in the curriculum. The course work has a heavier emphasis on quantitative analysis and fundamental physical principles than most biologically-oriented training programs. First year students also complete three 10 week lab rotations and attend a lecture series on Responsible Conduct of Research; a lab safety presentation is compulsory. At the end of the year, they must demonstrate proficiency in biochemistry and molecular and cellular biology in an oral exam. Second year students take Organic Mechanisms in Biology and three electives; students in a computational track substitute Statistical Mechanics for an elective. Second year students also present a formal seminar on a current topic in biophysics and take an oral qualifying exam. Currently 16 first and second year students are supported by the program, out of a total of 43 program students. Four program students are supported by a one-time grant from the Burroughs Wellcome Foundation designed to encourage students with math- and computer-intensive backgrounds to move into biological research; this program has in essence been continued with a supplement awarded in 2003 for recruitment of students into a computational track.

描述（由申请人提供）：分子和计算生物物理学计划正在寻求更新其培训补助金。生物物理学的詹金斯部门（艺术与科学，霍姆伍德校园）和生物物理学和生物物理化学（医学院，东巴尔的摩校园）的部门形成了该计划的核心相对于管理和课程; 44名教师，来自15个部门和两个校区之间的平均分配，参加培训活动。学生可以自由地在校园和实验室之间流动，进行课程作业、轮换和论文研究。培训教师名册已经发展到包括更多的教师在NMR，X射线晶体学，膜蛋白，计算生物物理学和生物化学转化领域工作。44个参与的实验室有一个强烈的社区意识产生的活动，如年度务虚会，每月晚上生物物理讨论，和两年一度的约翰霍普金斯折叠会议。教师还可以使用X射线晶体学，超离心和高场NMR的共享仪器设施。 在第一年，学生采取四个核心课程专门为该计划设计：生物大分子的物理化学;蛋白质和核酸;分子生物物理学方法;和生物大分子的计算机建模;课程最近进行了修改，以增加文献阅读，课堂时间用于讨论，并在课程中进行计算机编程练习。课程工作有一个更重的定量分析和基本的物理原理比大多数生物学为导向的培训计划的重点。一年级学生还完成三个10周的实验室轮换，并参加一系列关于负责任的研究行为的讲座;实验室安全演示是强制性的。在这一年结束时，他们必须在口头考试中展示生物化学和分子与细胞生物学的熟练程度。二年级的学生参加生物学中的有机机制和三门选修课;计算轨道的学生将选修统计力学。二年级的学生还将参加一个关于生物物理学当前主题的正式研讨会，并参加一个口头资格考试。目前，该项目共有43名学生，其中16名一年级和二年级的学生得到了该项目的支持。四个程序的学生是由一个一次性补助金支持的巴勒斯·惠康基金会，旨在鼓励学生数学和计算机密集型的背景，进入生物研究;这一计划在本质上一直在继续与补充授予2003年的学生进入计算轨道的招聘。