Modeling, Monitoring and Control of Hydrocephalus

描述(申请人提供)：脑积水的建模、监测和控制。我们的长期目标是设计和测试反馈控制系统，以更好地治疗交通性脑积水。新的分流系统配备了微电子遥测容量传感器和监测器，结合主动反馈，如果阶段特异性干预在发病机制中被证明是重要的，则可以显著改善患者的护理和预后。磁共振相位对比成像和体内颅内压测量的进展为了解正常和脑积水患者脑脊液的速度和压力分布提供了新的见解。从我们初步的临床和实验工作中得出的第一原理模型量化了脑脊液流量和顺应性脑组织。在新数据和建模进展的推动下，提出了探索一种新的微电遥测容量传感器用于监测和直接控制脑室大小的可行性。对于探索性R-21计划，三个具体目标是：目标1：实现交通性脑积水时脑实质三维生物力学变形的流固耦合模型，并使用脑积水患者的磁共振成像对该模型进行验证。目的2：微电遥测脑室容量传感器及监护仪的设计目的3：小型化脑室容量传感器与主动微泵反馈控制分流疗法的理论与实验研究该传感器与脑室大小及颅内压的主动反馈控制相结合，有望为交通性脑积水患者提供新的诊断和治疗方法。

DESCRIPTION (provided by applicant): Modeling, Monitoring and Control of Hydrocephalus. Our long range goal is to design and test a feedback control system for a better treatment of communicating hydrocephalus. New shunting systems equipped with a micro-electro telemetry volume sensor and monitor in conjunction with active feedback could significantly improve patient care and outcome if stage-specific intervention proves to be of importance in pathogenesis. Advances in MR phase contrast imaging and in-vivo intracranial pressure measurements provide new insights into the velocity and pressure distributions of cerebrospinal fluid in normal and hydrocephalic patients. A first principle model derived from our preliminary clinical and experimental work quantifies the CSF flow and the compliant brain tissue. Motivated by new data and modeling progress, it is proposed to explore the feasibility of a new micro-electro telemetry volume sensor for monitoring and directly controlling the ventricular size. For the exploratory R-21 program three specific goals are: Aim 1: Implementation of a fluid-structure interaction model for three-dimensional biomechanical deformation of the brain parenchyma in communicating hydrocephalus and validation of the model using MR imaging of hydrocephalic patients. Aim 2: The design of a micro-electro telemetry ventricular volume sensor and monitor Aim 3: A theoretical and experimental study of a feedback control shunt therapy with miniaturized volume sensor coupled with active micro pumping The novel sensor combined with active feedback control of ventricular size and ICP is expected to provide new diagnostic and therapeutic methods currently not available for patients suffering from communicating hydrocephalus.