Modeling, Monitoring and Control of Hydrocephalus

描述（由申请人提供）：脑积水的建模、监测和控制。我们的长期目标是设计和测试一个反馈控制系统，以更好地治疗交通性脑积水。新的分流系统配备了一个微电子遥测容量传感器和监测器结合主动反馈，可以显着改善患者的护理和结果，如果阶段特定的干预被证明是重要的发病机制。MR相位对比成像和颅内压测量的进展为正常和脑积水患者脑脊液的速度和压力分布提供了新的见解。从我们的初步临床和实验工作中获得的第一原理模型量化了CSF流量和顺应性脑组织。受新数据和建模进展的启发，提出探索一种新的微电遥测容积传感器用于监测和直接控制心室大小的可行性。对于探索性R-21计划，有三个具体目标：目标1：实施交通性脑积水脑实质三维生物力学变形的流体-结构相互作用模型，并使用脑积水患者的MR成像验证模型。目标二：微电遥测脑室容量传感器和监护仪的设计目的3：一个反馈控制分流治疗的理论和实验研究与微型容量传感器耦合主动微泵的新型传感器结合主动反馈控制脑室大小和颅内压，预计将提供新的诊断和治疗方法，目前还没有为患者患有交通性脑积水。

DESCRIPTION (provided by applicant): Modeling, Monitoring and Control of Hydrocephalus. Our long range goal is to design and test a feedback control system for a better treatment of communicating hydrocephalus. New shunting systems equipped with a micro-electro telemetry volume sensor and monitor in conjunction with active feedback could significantly improve patient care and outcome if stage-specific intervention proves to be of importance in pathogenesis. Advances in MR phase contrast imaging and in-vivo intracranial pressure measurements provide new insights into the velocity and pressure distributions of cerebrospinal fluid in normal and hydrocephalic patients. A first principle model derived from our preliminary clinical and experimental work quantifies the CSF flow and the compliant brain tissue. Motivated by new data and modeling progress, it is proposed to explore the feasibility of a new micro-electro telemetry volume sensor for monitoring and directly controlling the ventricular size. For the exploratory R-21 program three specific goals are: Aim 1: Implementation of a fluid-structure interaction model for three-dimensional biomechanical deformation of the brain parenchyma in communicating hydrocephalus and validation of the model using MR imaging of hydrocephalic patients. Aim 2: The design of a micro-electro telemetry ventricular volume sensor and monitor Aim 3: A theoretical and experimental study of a feedback control shunt therapy with miniaturized volume sensor coupled with active micro pumping The novel sensor combined with active feedback control of ventricular size and ICP is expected to provide new diagnostic and therapeutic methods currently not available for patients suffering from communicating hydrocephalus.