Modeling, Monitoring and Control of Hydrocephalus

脑积水的建模、监测和控制

• 批准号: 7418333
• 负责人: ANDREAS A LINNINGER
• 金额: $ 18.66万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7418333
• 关键词: Arts; Biomechanics; Brain; Canis familiaris; Cerebrospinal Fluid; Cerebrum; Chicago; Clinical; Communicating Hydrocephalus; Coupled; Development; Feedback; Goals; Human; Hydrocephalus; Image; Indium; Intervention; Intracranial Pressure; Liquid substance; Magnetic Resonance Imaging; Maintenance; Measurement; Methods; Modeling; Monitor; Outcome; Pathogenesis; Patient Care; Patients; Phase; Plastics; Protocols documentation; Pump; Range; Science; Shunt Device; Staging; Structure; System; Techniques; Telemetry; Testing; Therapeutic; Universities; Validation; Vascular System; Ventricular; Work; base; brain tissue; cerebrospinal fluid flow; data modeling; design; human data; improved; in vivo; insight; miniaturize; novel; novel diagnostics; pressure; programs; research study; sensor; size; three-dimensional modeling; volunteer

DESCRIPTION (provided by applicant): Modeling, Monitoring and Control of Hydrocephalus. Our long range goal is to design and test a feedback control system for a better treatment of communicating hydrocephalus. New shunting systems equipped with a micro-electro telemetry volume sensor and monitor in conjunction with active feedback could significantly improve patient care and outcome if stage-specific intervention proves to be of importance in pathogenesis. Advances in MR phase contrast imaging and in-vivo intracranial pressure measurements provide new insights into the velocity and pressure distributions of cerebrospinal fluid in normal and hydrocephalic patients. A first principle model derived from our preliminary clinical and experimental work quantifies the CSF flow and the compliant brain tissue. Motivated by new data and modeling progress, it is proposed to explore the feasibility of a new micro-electro telemetry volume sensor for monitoring and directly controlling the ventricular size. For the exploratory R-21 program three specific goals are: Aim 1: Implementation of a fluid-structure interaction model for three-dimensional biomechanical deformation of the brain parenchyma in communicating hydrocephalus and validation of the model using MR imaging of hydrocephalic patients. Aim 2: The design of a micro-electro telemetry ventricular volume sensor and monitor Aim 3: A theoretical and experimental study of a feedback control shunt therapy with miniaturized volume sensor coupled with active micro pumping The novel sensor combined with active feedback control of ventricular size and ICP is expected to provide new diagnostic and therapeutic methods currently not available for patients suffering from communicating hydrocephalus.

描述（申请人提供）：脑积水的建模、监测和控制。我们的长期目标是设计和测试一种反馈控制系统，以更好地治疗通讯性脑积水。如果阶段特异性干预在发病机制中被证明是重要的，那么配备微电遥测体积传感器和监视器的新型分流系统可以显着改善患者的护理和结果。磁共振相位对比成像和体内颅内压测量的进展为正常和脑积水患者脑脊液的速度和压力分布提供了新的见解。从我们初步的临床和实验工作中得出的第一原理模型量化了脑脊液流和顺应性脑组织。在新的数据和建模进展的激励下，提出探索一种新型的微电遥测容积传感器用于监测和直接控制心室大小的可行性。探索性R-21项目有三个具体目标：目标1：建立沟通性脑积水时脑实质三维生物力学变形的流固相互作用模型，并利用脑积水患者的MR成像验证该模型。目的3：微型容积传感器与主动微泵相结合的反馈控制分流治疗的理论与实验研究。新型传感器与心室大小和ICP的主动反馈控制相结合，有望为通讯性脑积水患者提供新的诊断和治疗方法。

项目成果

Dynamic brain phantom for intracranial volume measurements.

用于颅内体积测量的动态大脑模型。

• DOI: 10.1109/tbme.2010.2050065
• 发表时间: 2011
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Basati,SukhraajS;Harris,TimothyJ;Linninger,AndreasA
• 通讯作者: Linninger,AndreasA

Cerebral microcirculation and oxygen tension in the human secondary cortex.

• DOI: 10.1007/s10439-013-0828-0
• 发表时间: 2013-11
• 期刊: ANNALS OF BIOMEDICAL ENGINEERING
• 影响因子: 3.8
• 作者: Linninger, A. A.;Gould, I. G.;Marinnan, T.;Hsu, C. -Y.;Chojecki, M.;Alaraj, A.
• 通讯作者: Alaraj, A.

Three-dimensional computational prediction of cerebrospinal fluid flow in the human brain.

• DOI: 10.1016/j.compbiomed.2010.12.001
• 发表时间: 2011-02
• 期刊: COMPUTERS IN BIOLOGY AND MEDICINE
• 影响因子: 7.7
• 作者: Sweetman, Brian;Xenos, Michalis;Zitella, Laura;Linninger, Andreas A.
• 通讯作者: Linninger, Andreas A.