ANIMAL VALIDATION OF A NEW VOLUME SENSOR FOR FEEDBACK TREATMENT OF HYDROCEPHALUS

用于脑积水反馈治疗的新型容量传感器的动物验证

• 批准号: 8073574
• 负责人: ANDREAS A LINNINGER
• 金额: $ 14.99万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073574
• 关键词: Adolescent; Adult; Affect; Algorithms; Animal Experimentation; Animal Model; Animals; Birth; Caliber; Canis familiaris; Catheters; Childhood; Chronic; Computer Assisted; Computer Simulation; Computer-Aided Design; Consumption; Core Facility; Coupled; Deposition; Device Designs; Devices; Disease; Electrodes; Electroplating; Feedback; Goals; Grant; Histology; Human; Hydrocephalus; Image; Implant; Knowledge; MRI Scans; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Medical Imaging; Methods; Microfabrication; Modeling; Monitor; Nanotechnology; Patients; Performance; Platinum; Positioning Attribute; Preparation; Pressure Transducers; Principal Investigator; Rattus; Research; Series; Shunt Device; Simulate; Surface; System; Techniques; Testing; Time; Treatment Cost; United States National Institutes of Health; Validation; Ventricular; Vision; Work; age group; base; biomaterial compatibility; data acquisition; design; electric field; electric impedance; experience; image reconstruction; implantation; improved; in vivo; instrumentation; manufacturing process; mathematical model; miniaturize; novel; novel strategies; parylene; pressure; public health relevance; radiofrequency; research study; scale up; scientific computing; sensor; simulation

DESCRIPTION (provided by applicant): Hydrocephalus is a disease affecting one in 1,000 births, or 70,000 patients a year. Treatment cost in the U.S. for shunt revision amount to one billion dollars every year. Despite the significance of hydrocephalus, there is a lack of improvement for its treatment. Based on recent findings of our group in intracranial dynamics, proof-of- principle of a new impedance volume measurement with a prior NIH R-21 grant and comprehensive preliminary work in preparation of this proposal, we have confidence in the possibility of improving hydrocephalus treatment options. Our contention is that a new approach is necessary for proper maintenance of childhood and adult hydrocephalus. In this proposal, we wish to test a novel impedance volume sensor in small and large hydrocephalic animals. The overall vision of the project aims at improving hydrocephalus therapy based on volume sensing combined with active feedback. To realize this vision, we propose the following three specific aims: Aim #1. Chronic implantation into rat hydrocephalic model. We propose to induce hydrocephalus in juvenile rats. Dynamic volume measurements will be made with a miniaturized rat micro-sensor for a period of up to 30 days. MRI scans of the ventricles will independently verify sensor accuracy. The experience gained from rat experiments will be incorporated into a dog model. Aim #2. Intracranial volume and pressure monitoring in mongrel dogs. Sensors will be scaled for chronic dog experiments. Sensor, instrumentation and data acquisition will be implanted into a small number of hydrocephalic animals. Micro-electromechanical pressure transducers will be incorporated to acquire dynamic pressure alongside ventricular volume measurements. Real-time pressure and volume changes occurring in hydrocephalus have never been monitored simultaneously to the best of our knowledge. Aim #3. Computer-aided design of a human monitoring and control system. We will incorporate animal results into a computer-aided design for a human therapy. We will simulate ventricular expansion in hydrocephalus to determine the optimal sensor parameters for a human system. Sensor performance with an active feedback control shunting will be simulated. The proposed research will lay out the parameters and expected performance of a novel treatment system based on the novel volume measurement with active feedback control. PUBLIC HEALTH RELEVANCE: The key idea in this interdisciplinary project is to manufacture a novel impedance-based ventricular volume sensor for hydrocephalic animals. Microfabrication techniques will be used in combination with advanced medical imaging and scientific computing methods to design a novel sensor with optimal accuracy and sensitivity. The senor will be tested in a series of rat experiments. The sensor and instrumentation will be scaled for an implantable ventricular size monitor for a mongrel dog hydrocephalus model. New knowledge obtained from measuring the ventricular expansion in the course of induced hydrocephalus will be used to designing a monitoring and control systems for humans. The fundamental knowledge gain will pave the way for novel treatment options of hydrocephalus with active volume sensing and feedback.

描述（由申请人提供）：脑积水是一种疾病，影响1000个新生儿中的一个，或每年70000个患者。在美国，每年用于分流修复的治疗费高达10亿美元。尽管脑积水的重要性，缺乏改善其治疗。基于我们小组在颅内动力学方面的最新发现，一种新的阻抗体积测量的原理证明与先前的NIH R-21拨款以及准备该提案的全面初步工作，我们对改善脑积水治疗选择的可能性充满信心。我们的论点是一种新的方法是必要的儿童和成人脑积水的适当维护。在本提案中，我们希望在小型和大型脑积水动物中测试一种新型阻抗体积传感器。该项目的总体愿景旨在改进基于体积传感与主动反馈相结合的脑积水治疗。为实现这一愿景，我们提出以下三个具体目标：慢性植入大鼠脑积水模型。我们拟诱导幼年大鼠脑积水。在长达30天的时间里，将使用微型老鼠微传感器进行动态体积测量。心室的核磁共振扫描将独立验证传感器的准确性。从大鼠实验中获得的经验将被纳入狗模型。目标# 2。杂种犬颅内容量和压力监测。传感器将按比例进行长期的狗实验。传感器、仪器和数据采集将被植入少量脑积水动物体内。微机电压力传感器将被纳入以获得动态压力和心室容积测量。据我们所知，脑积水中发生的实时压力和体积变化从未同时监测过。目标# 3。人机监控系统的计算机辅助设计。我们将把动物实验的结果纳入人类治疗的计算机辅助设计中。我们将模拟脑积水的心室扩张，以确定人体系统的最佳传感器参数。传感器性能与主动反馈控制分流将模拟。本研究将提出一种基于主动反馈控制的新型体积测量的新型处理系统的参数和预期性能。