ANIMAL VALIDATION OF A NEW VOLUME SENSOR FOR FEEDBACK TREATMENT OF HYDROCEPHALUS

用于脑积水反馈治疗的新型容量传感器的动物验证

• 批准号: 7963774
• 负责人: ANDREAS A LINNINGER
• 金额: $ 27.08万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7963774
• 关键词: Adolescent; Adult; Affect; Algorithms; Animal Experimentation; Animal Model; Animals; Birth; Caliber; Canis familiaris; Catheters; Childhood; Chronic; Computer Assisted; Computer Simulation; Computer-Aided Design; Consumption; Core Facility; Coupled; Deposition; Device Designs; Devices; Disease; Electrodes; Electroplating; Feedback; Goals; Grant; Histology; Human; Hydrocephalus; Image; Implant; Knowledge; MRI Scans; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Medical Imaging; Methods; Microfabrication; Modeling; Monitor; Nanotechnology; Patients; Performance; Platinum; Positioning Attribute; Preparation; Pressure Transducers; Principal Investigator; Rattus; Research; Series; Shunt Device; Simulate; Surface; System; Techniques; Testing; Time; Treatment Cost; United States National Institutes of Health; Validation; Ventricular; Vision; Work; age group; base; biomaterial compatibility; data acquisition; design; electric field; electric impedance; experience; image reconstruction; implantation; improved; in vivo; instrumentation; manufacturing process; mathematical model; miniaturize; novel; novel strategies; parylene; pressure; public health relevance; radiofrequency; research study; scale up; scientific computing; sensor; simulation

DESCRIPTION (provided by applicant): Hydrocephalus is a disease affecting one in 1,000 births, or 70,000 patients a year. Treatment cost in the U.S. for shunt revision amount to one billion dollars every year. Despite the significance of hydrocephalus, there is a lack of improvement for its treatment. Based on recent findings of our group in intracranial dynamics, proof-of- principle of a new impedance volume measurement with a prior NIH R-21 grant and comprehensive preliminary work in preparation of this proposal, we have confidence in the possibility of improving hydrocephalus treatment options. Our contention is that a new approach is necessary for proper maintenance of childhood and adult hydrocephalus. In this proposal, we wish to test a novel impedance volume sensor in small and large hydrocephalic animals. The overall vision of the project aims at improving hydrocephalus therapy based on volume sensing combined with active feedback. To realize this vision, we propose the following three specific aims: Aim #1. Chronic implantation into rat hydrocephalic model. We propose to induce hydrocephalus in juvenile rats. Dynamic volume measurements will be made with a miniaturized rat micro-sensor for a period of up to 30 days. MRI scans of the ventricles will independently verify sensor accuracy. The experience gained from rat experiments will be incorporated into a dog model. Aim #2. Intracranial volume and pressure monitoring in mongrel dogs. Sensors will be scaled for chronic dog experiments. Sensor, instrumentation and data acquisition will be implanted into a small number of hydrocephalic animals. Micro-electromechanical pressure transducers will be incorporated to acquire dynamic pressure alongside ventricular volume measurements. Real-time pressure and volume changes occurring in hydrocephalus have never been monitored simultaneously to the best of our knowledge. Aim #3. Computer-aided design of a human monitoring and control system. We will incorporate animal results into a computer-aided design for a human therapy. We will simulate ventricular expansion in hydrocephalus to determine the optimal sensor parameters for a human system. Sensor performance with an active feedback control shunting will be simulated. The proposed research will lay out the parameters and expected performance of a novel treatment system based on the novel volume measurement with active feedback control. PUBLIC HEALTH RELEVANCE: The key idea in this interdisciplinary project is to manufacture a novel impedance-based ventricular volume sensor for hydrocephalic animals. Microfabrication techniques will be used in combination with advanced medical imaging and scientific computing methods to design a novel sensor with optimal accuracy and sensitivity. The senor will be tested in a series of rat experiments. The sensor and instrumentation will be scaled for an implantable ventricular size monitor for a mongrel dog hydrocephalus model. New knowledge obtained from measuring the ventricular expansion in the course of induced hydrocephalus will be used to designing a monitoring and control systems for humans. The fundamental knowledge gain will pave the way for novel treatment options of hydrocephalus with active volume sensing and feedback.

描述（由申请人提供）：脑积水是一种影响千分之一新生儿或每年 70,000 名患者的疾病。在美国，每年分流修复的治疗费用达 10 亿美元。尽管脑积水很重要，但其治疗仍缺乏改进。基于我们小组在颅内动力学方面的最新发现、先前获得 NIH R-21 资助的新阻抗体积测量的原理验证以及准备本提案的全面前期工作，我们对改善脑积水治疗方案的可能性充满信心。我们的观点是，为了正确维持儿童和成人脑积水，需要一种新方法。在本提案中，我们希望在小型和大型脑积水动物中测试一种新型阻抗体积传感器。该项目的总体愿景旨在改善基于容量传感与主动反馈相结合的脑积水治疗。为了实现这一愿景，我们提出以下三个具体目标： 目标#1。慢性植入大鼠脑积水模型。我们建议在幼年大鼠中诱导脑积水。动态体积测量将使用微型大鼠微传感器进行，持续时间长达 30 天。心室 MRI 扫描将独立验证传感器的准确性。从老鼠实验中获得的经验将被纳入狗模型中。目标#2。杂种狗的颅内容积和压力监测。传感器将针对长期狗实验进行缩放。传感器、仪器和数据采集器将被植入少量脑积水动物体内。将采用微机电压力传感器来获取动态压力以及心室容积测量。据我们所知，从未同时监测过脑积水发生的实时压力和体积变化。目标#3。人体监测和控制系统的计算机辅助设计。我们将把动物实验结果纳入人类治疗的计算机辅助设计中。我们将模拟脑积水的心室扩张，以确定人体系统的最佳传感器参数。将模拟具有主动反馈控制分流的传感器性能。拟议的研究将列出基于主动反馈控制的新型体积测量的新型治疗系统的参数和预期性能。 公共健康相关性：这个跨学科项目的关键思想是为脑积水动物制造一种新型的基于阻抗的心室容量传感器。微加工技术将与先进的医学成像和科学计算方法相结合，设计出具有最佳精度和灵敏度的新型传感器。该传感器将在一系列大鼠实验中进行测试。传感器和仪器将针对杂种狗脑积水模型的植入式心室大小监测器进行缩放。通过测量诱发脑积水过程中的心室扩张获得的新知识将用于设计人类监测和控制系统。基础知识的获得将为通过主动体积传感和反馈的脑积水新治疗方案铺平道路。