Atherosclerotic Plaque Neovascular Inflation

动脉粥样硬化斑块新生血管充气

• 批准号: 7179356
• 负责人: KIRK W BEACH
• 金额: $ 22.31万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7179356
• 关键词: 3-Dimensional; Abnormal Cell; Accounting; Address; Animals; Area; Arterial Fatty Streak; Arteries; Atherosclerosis; Blood; Blood Pressure; Blood Vessels; Budgets; Caliber; Carotid Arteries; Carotid Artery Diseases; Carotid Artery Plaques; Carotid Endarterectomy; Carotid Stenosis; Cause of Death; Cessation of life; Characteristics; Coronary artery; Coronary heart disease; Correlative Study; Data; Diagnosis; Diagnostic Procedure; Diastole; Dimensions; Disease; Economic Inflation; Event; Facilities and Administrative Costs; Goals; Gold; Healthcare; Hemorrhage; Histology; Hyperlipidemia; Hypertension; Image; Ischemic Stroke; Knowledge; Lateral; Lipids; Liquid substance; Malignant Neoplasms; Maps; Measurement; Measures; Mental Depression; Methods; Modeling; Neck; Normal Statistical Distribution; Numbers; Nutrient; Operative Surgical Procedures; Oxygen; Pathology; Patients; Prevalence; Procedures; Process; Protocols documentation; Reporting; Research Personnel; Resistance; Resolution; Respiration; Risk; Rupture; Sampling; Senile Plaques; Severities; Signal Transduction; Skin; Solutions; Standards of Weights and Measures; Statistical Distributions; Stenosis; Stroke; Stroke prevention; Structure; Surface; Symptoms; Systole; Testing; Thick; Time; Tissues; Translating; Ultrasonics; Ultrasonography; United States; Veins; computerized data processing; cost; density; disability; heart rhythm; life time cost; nanometer; neovascular; nutrition; pressure; programs; prospective; systems research; vasa vasorum

DESCRIPTION (provided by applicant): The vasa vasorum are a network of tiny arteries and veins on the outer wall of major blood vessels which penetrate into the wall to supply respiration and nutrition to the vascular wall. In addition, these vessels penetrate through the arterial wall and into neovessels in the atherosclerotic plaques to provide nutrients and oxygen to the abnormal cells forming the plaque. The blood in the intraplaque neovessels is squeezed out in systole and inflates the neovessels in diastole. We are developing an ultrasound examination method that can be performed through the skin of the neck to measure the strain (deformation) of these plaques. By determining the arterial pressure when the neovessels inflate, the pressure in the vasa vasorum can be determined; the inflation volume is equal to the neovascular volume. Atherosclerotic carotid artery plaques which have a large neovascular volume are vulnerable to rupture, causing a stroke. The ultrasonic measurement developed in this project will differentiate such plaques from those that are stable. In this study we will measure the plaque strain in 300 patients to provide a distribution of normal and abnormal strain values in the people who have stenotic atherosclerotic carotid artery plaques.

描述（申请人提供）： 滋养管是主要血管外壁上的微小动脉和静脉的网络，它们穿入血管壁，为血管壁提供呼吸和营养。此外，这些血管穿透动脉壁并进入动脉粥样硬化斑块中的新生血管，为形成斑块的异常细胞提供营养和氧气。斑块内新生血管中的血液在收缩期被挤出，并在舒张期使新生血管膨胀。我们正在开发一种超声波检查方法，可以通过颈部皮肤进行测量这些斑块的应变（变形）。通过确定新生血管膨胀时的动脉压，可以确定血管滋养管的压力；膨胀体积等于新生血管体积。具有大量新生血管的动脉粥样硬化颈动脉斑块很容易破裂，导致中风。该项目中开发的超声波测量将区分此类斑块和稳定斑块。在这项研究中，我们将测量 300 名患者的斑块应变，以提供患有狭窄动脉粥样硬化颈动脉斑块的人的正常和异常应变值的分布。