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Atherosclerotic Plaque Neovascular Inflation

动脉粥样硬化斑块新生血管充气

基本信息

批准号：
7350891
负责人：
KIRK W BEACH
金额：
$ 18.52万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-01 至 2009-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7350891
关键词：
3-Dimensional Abnormal Cell Accounting Address Animals Area Arterial Fatty Streak Arteries Atherosclerosis Blood Blood Pressure Blood Vessels Budgets Caliber Carotid Arteries Carotid Artery Diseases Carotid Artery Plaques Carotid Endarterectomy Carotid Stenosis Cause of Death Cessation of life Characteristics Coronary artery Coronary heart disease Correlative Study Data Diagnosis Diagnostic Procedure Diastole Dimensions Disease Economic Inflation Event Facilities and Administrative Costs Goals Gold Healthcare Hemorrhage Histology Hyperlipidemia Hypertension Image Ischemic Stroke Knowledge Lateral Lipids Liquid substance Malignant Neoplasms Maps Measurement Measures Mental Depression Methods Modeling Neck Normal Statistical Distribution Numbers Nutrient Operative Surgical Procedures Oxygen Pathology Patients Prevalence Procedures Process Protocols documentation Reporting Research Personnel Resistance Resolution Respiration Risk Rupture Sampling Senile Plaques Severities Signal Transduction Skin Solutions Standards of Weights and Measures Statistical Distributions Stenosis Stroke Stroke prevention Structure Surface Symptoms Systole Testing Thick Time Tissues Translating Ultrasonics Ultrasonography United States Veins computerized data processing cost density disability heart rhythm life time cost nanometer neovascular nutrition pressure programs prospective systems research vasa vasorum

项目摘要

DESCRIPTION (provided by applicant): The vasa vasorum are a network of tiny arteries and veins on the outer wall of major blood vessels which penetrate into the wall to supply respiration and nutrition to the vascular wall. In addition, these vessels penetrate through the arterial wall and into neovessels in the atherosclerotic plaques to provide nutrients and oxygen to the abnormal cells forming the plaque. The blood in the intraplaque neovessels is squeezed out in systole and inflates the neovessels in diastole. We are developing an ultrasound examination method that can be performed through the skin of the neck to measure the strain (deformation) of these plaques. By determining the arterial pressure when the neovessels inflate, the pressure in the vasa vasorum can be determined; the inflation volume is equal to the neovascular volume. Atherosclerotic carotid artery plaques which have a large neovascular volume are vulnerable to rupture, causing a stroke. The ultrasonic measurement developed in this project will differentiate such plaques from those that are stable. In this study we will measure the plaque strain in 300 patients to provide a distribution of normal and abnormal strain values in the people who have stenotic atherosclerotic carotid artery plaques.

描述（由申请人提供）：血管管是在主要血管外壁上由细小的动脉和静脉组成的网络，它们穿透血管壁，为血管壁提供呼吸和营养。此外，这些血管穿过动脉壁，进入动脉粥样硬化斑块内的新血管，为形成斑块的异常细胞提供营养和氧气。在收缩期，斑块内新生血管中的血液被挤出，在舒张期使新生血管膨胀。我们正在开发一种超声检查方法，可以通过颈部皮肤来测量这些斑块的应变（变形）。通过测定新生血管膨胀时的动脉压力，可以确定血管内的压力；膨胀体积等于新生血管体积。颈动脉粥样硬化斑块有很大的新生血管容量，很容易破裂，引起中风。在这个项目中开发的超声波测量将区分这些斑块和那些稳定的斑块。在这项研究中，我们将测量300名患者的斑块应变，以提供患有狭窄的动脉粥样硬化性颈动脉斑块的人的正常和异常应变值的分布。