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3D NEURAL RECORDING SYSTEM: SELF-ASSEMBLY TOOLS AND TEST

3D 神经记录系统：自组装工具和测试

基本信息

批准号：
7230182
负责人：
HEIKO O JACOBS
金额：
$ 17.27万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2009-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This is a "revised" R21 application submitted in response to the "Neurotechnology Research, Development, and Enhancement" program announcement to develop and test a 3D multi-channel wireless optical neural recording system. The "first goal" of the proposed research is to develop a wireless optical neural recording system to overcome the limitations of current systems which are expensive, complex, and difficult to use. Current cabling to connect the neural implant to the amplifiers and computers limit the range of experiments that can be done. A wire-less system would greatly simplify and extend recording technology for behavioral neuroscience and find uses in epilepsy and other disease studies. The proposed system has a 3D topology. It consists of an array of optical pixel elements that are connected to a silicon platform containing an array of through holes that contain folded microfabricated silicon electrodes. The pixels amplify the neuron signals and optically transmit the signals to a remote camera. The system cannot be fabricated using traditional methods due to the required 3D topology. Traditional methods, including surface micromachining and robotic assembly lines limit the biomedical device community to 2D device topologies. The "second goal" of the proposed research is to overcome this limitation. The development of novel tools are proposed to realize the neural recording system. The tools are based on self-assembly and folding; in particular, a (i) sequential self-assembly process to fabricate, assemble, and electrically connect the pixel elements with the recording electrodes, and a (ii) folding process to rotate the recording electrodes in an out-of-plane position. The tools benefit the biomedical device community in general as they enable the rapid prototyping of 3D-miniaturized systems. The "third goal" is to test the realized system. The first system will contain an array of 96 pixels connected to 16 electrodes with 6 recording sites. The system will be used to measure local field potentials in awake-behaving rats to gain insight into the role of striatal local field potentials in behavior.

说明(申请人提供)：这是一份“修订”的R21申请，是对“神经技术研究、开发和增强”计划公告的回应，目的是开发和测试3D多通道无线光学神经记录系统。这项研究的“第一个目标”是开发一种无线光学神经记录系统，以克服目前系统昂贵、复杂和难以使用的局限性。目前连接神经植入物和放大器和计算机的电缆限制了可以进行的实验范围。无线系统将极大地简化和扩展行为神经科学的记录技术，并在癫痫和其他疾病研究中找到用途。所提出的系统具有3D拓扑结构。它由连接到硅平台的光学像素元件阵列组成，所述硅平台包含包含折叠的微制造硅电极的通孔阵列。像素放大神经元信号，并将信号光学传输到远程摄像机。由于所需的3D拓扑，该系统不能使用传统方法制造。传统的方法，包括表面微加工和机器人装配线，将生物医学设备社区限制在2D设备拓扑结构中。这项拟议研究的“第二个目标”就是克服这一局限。提出了实现神经记录系统的新工具的开发。该工具基于自组装和折叠；具体地，(I)制造、组装像素元件并将其与记录电极电连接的顺序自组装工艺，以及(Ii)在平面外位置旋转记录电极的折叠工艺。这些工具总体上有利于生物医学设备社区，因为它们能够快速制作3D微型化系统的原型。“第三个目标”是测试实现的系统。第一个系统将包含一个96个像素的阵列，连接到16个电极和6个记录点。该系统将用于测量清醒行为大鼠的局部场电位，以深入了解纹状体局部场电位在行为中的作用。