Modelling cell choice in development and disease

发育和疾病中的细胞选择建模

• 批准号: 2905743
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2905743
• 关键词: Modelling; cell; choice; development; disease

This project involves the development and analysis of original mathematical models addressing mechanoregulation in biological tissues and its impact on the early stages of cancer progression. Working with collaborators (Dr Sarah Woolner & Dr Kerrie Marie in the Faculty of Biology, Medicine & Health, University of Manchester), the project will target the properties and behaviour of mammalian neural crest cells. These migratory and multipotent cells can develop into melanocytes, pigment-producing cells that are susceptible to transformation into the skin cancer melanoma. Exploiting data from the Woolner and Marie labs revealing cell-shape changes in mouse melanocyte precursor tissues under mechanical loading, the project will use mathematical and computational models to address the relationship of such changes to lineage progression in early tumour formation.

这个项目涉及开发和分析原始的数学模型，解决生物组织中的机械调节及其对癌症进展早期阶段的影响。与合作者(曼彻斯特大学生物、医学和健康学院的Sarah Woolner博士和Kerrie Marie博士)合作，该项目将以哺乳动物神经脊细胞的特性和行为为目标。这些迁移和多能细胞可以发育成黑素细胞，这种产生色素的细胞很容易转化为皮肤癌黑色素瘤。利用来自Woolner和Marie实验室的数据揭示在机械载荷下小鼠黑素细胞前体组织的细胞形状变化，该项目将使用数学和计算模型来解决这种变化与早期肿瘤形成的谱系进展的关系。