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Semantic Interference and Early Detection of Dementia

语义干扰和痴呆症的早期检测

基本信息

批准号：
7228075
负责人：
DAVID LOEWENSTEIN
金额：
$ 40.52万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-06-01 至 2010-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7228075
关键词：
Alleles Alzheimer&apos s Disease Apolipoprotein E Benign Brain Caucasians Caucasoid Race Clinical Cognitive Communities Condition Data Degenerative Disorder Delayed Memory Dementia Detection Development Diagnosis Disease Disease Progression Doctor of Philosophy Early Diagnosis Elderly Event Exhibits Future Genotype Hispanics Impaired cognition Impairment Individual Investigation Laboratories Language Measures Memory Memory Disorders Memory impairment Neuropsychological Tests Not Hispanic or Latino Patients Performance Persons Pilot Projects Populations at Risk Prevalence Purpose Rate Risk Score Semantics Sensitivity and Specificity Series Staging Testing Time Visuospatial Work base comparative executive function forgetting genetic risk factor heuristics instrument mild neurocognitive impairment neuropsychological novel older patient performance tests prospective memory skills

项目摘要

DESCRIPTION (provided by applicant): The prevalence of memory disorders increases with advancing age, presenting a challenge for clinicians who must differentiate a benign condition from a serious and progressive disorder. The early diagnosis of degenerative conditions such as Alzheimer's Disease (AD) is particularly important given the continuing development of novel pharmacological agents that show promise in decreasing the rate of progression of memory impairment. Future agents will likely be most effective by limiting the extent of brain impairment when administered early in the development of the disease, making early diagnosis critical. The purpose of the proposed investigation is to assess the utility, among Hispanic and non-Hispanic elderly who are at risk for cognitive decline, of two newly developed neuropsychological tests: the Semantic Interference Test (SIT) and the Prospective Memory Test (PMT). The SIT assesses proactive and retroactive semantic interference, whereas the PMT assesses event- and time-based prospective memory. Pilot work in our laboratories using English- and Spanish-speaking elderly indicates that vulnerability to semantic interference as measured by the SIT is a more sensitive indicator of cognitive impairment in the early stages of AD than traditional neuropsychological tests that assess delayed memory or rate of forgetting. Our data also indicate that the PMT has good sensitivity and specificity in differentiating mildly impaired AD patients from normal elderly controls. A unique aspect of this study is that the predictive utility of semantic interference and prospective memory measures will be compared to traditional neuropsychological tests in predicting cognitive decline and progression to dementia among elderly Hispanic and non-Hispanic patients who are normal or who have mild cognitive impairment (MCI). Genetic risk factors such as apolipoprotein E (ApoE) status will also be assessed with regards to its ability to predict, alone and in combination with SIT and PMT measures, which individuals will develop cognitive decline and progression to dementia. The study of increased vulnerability to semantic interference and decline in prospective memory may enhance the detection of MCI and the prediction of progression to dementia in at risk populations, thus having important clinical, heuristic, and treatment implications.

描述（由申请人提供）：记忆障碍的患病率随着年龄的增长而增加，这对临床医生提出了挑战，他们必须区分良性疾病和严重的进行性疾病。鉴于新型药理学药物的持续开发，这些药物有望降低记忆障碍的进展速度，阿尔茨海默病（AD）等退行性疾病的早期诊断尤为重要。未来的药物可能是最有效的，当在疾病发展的早期给药时，限制脑损伤的程度，使早期诊断至关重要。拟议的调查的目的是评估效用，西班牙裔和非西班牙裔老年人谁是在认知能力下降的风险，两个新开发的神经心理测试：语义干扰测试（SIT）和前瞻性记忆测试（PMT）。SIT评估主动和追溯语义干扰，而PMT评估基于事件和时间的前瞻性记忆。在我们的实验室中使用英语和西班牙语的老年人的试点工作表明，语义干扰的脆弱性所测量的SIT是一个更敏感的指标，在AD的早期阶段的认知障碍比传统的神经心理学测试，评估延迟记忆或遗忘率。我们的数据还表明，PMT在区分轻度受损的AD患者和正常老年人对照方面具有良好的敏感性和特异性。这项研究的一个独特的方面是，语义干扰和前瞻性记忆措施的预测效用将进行比较，传统的神经心理学测试在预测认知能力下降和进展为老年痴呆症的西班牙裔和非西班牙裔患者谁是正常的或谁有轻度认知障碍（MCI）。遗传风险因素，如载脂蛋白E（ApoE）状态也将评估其预测能力，单独和与SIT和PMT措施相结合，哪些人将发展认知能力下降和进展为痴呆症。对语义干扰和前瞻性记忆下降的脆弱性增加的研究可能会增强MCI的检测和对高危人群中痴呆进展的预测，从而具有重要的临床，启发式和治疗意义。

项目成果

期刊论文数量（21）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Severity of medial temporal atrophy and amnestic mild cognitive impairment: selecting type and number of memory tests.

内侧颞萎缩和遗忘性轻度认知障碍的严重程度：选择记忆测试的类型和数量。

DOI：
10.1097/jgp.0b013e3181b7ef42
发表时间：
2009
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
0
作者：
Loewenstein,DavidA;Acevedo,Amarilis;Potter,Elizabeth;Schinka,JohnA;Raj,Ashok;Greig,MariaT;Agron,Joscelyn;Barker,WarrenW;Wu,Yougui;Small,Brent;Schofield,Elizabeth;Duara,Ranjan
通讯作者：
Duara,Ranjan

The utility of age-specific cut-offs for visual rating of medial temporal atrophy in classifying Alzheimer's disease, MCI and cognitively normal elderly subjects.

DOI：
10.3389/fnagi.2013.00047
发表时间：
2013
期刊：
Frontiers in aging neuroscience
影响因子：
4.8
作者：
Duara R;Loewenstein DA;Shen Q;Barker W;Varon D;Greig MT;Curiel R;Agron J;Santos I;Potter H
通讯作者：
Potter H

An investigation of PreMCI: subtypes and longitudinal outcomes.

对PREMCI的调查：亚型和纵向结果。

DOI：
10.1016/j.jalz.2011.03.002
发表时间：
2012-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
0
作者：
Loewenstein DA;Greig MT;Schinka JA;Barker W;Shen Q;Potter E;Raj A;Brooks L;Varon D;Schoenberg M;Banko J;Potter H;Duara R
通讯作者：
Duara R

The use of amnestic and nonamnestic composite measures at different thresholds in the neuropsychological diagnosis of MCI.

在 MCI 的神经心理学诊断中使用不同阈值的遗忘和非遗忘复合测量。

DOI：
10.1080/13803390600681206
发表时间：
2007
期刊：
Journal of clinical and experimental neuropsychology
影响因子：
2.2
作者：
Loewenstein,DavidA;Acevedo,Amarilis;Agron,Joscelyn;Martinez,Glenda;Duara,Ranjan
通讯作者：
Duara,Ranjan

Evaluating different aspects of prospective memory in amnestic and nonamnestic mild cognitive impairment.