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High Throughput Transcriptomics and Proteomics

High Throughput Transcriptomics and Proteomics
高通量转录组学和蛋白质组学
批准号：
7270272
负责人：
STEVEN M KORNBLAU
金额：
$7.99万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-04-01 至 2012-03-31
来源：
https://reporter.nih.gov/project-details/7270272
关键词：
Antibody SpecificityBloodConditionCustomDiagnosisMarrowMesenchymal Stem CellsPatientsPharmaceutical PreparationsPhaseProtein ArrayProteomicsRNA InterferenceRelapseResearch PersonnelScreening procedureSpecimenStandards of Weights and MeasuresStem cellsTestingValidationdata acquisitionnovelprogramsprotein expressiontranscriptomics

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英文摘要
Aim 1.Provide standard Reverse Phase Protein Arrays (RPPA) from AMI patients to program project investigators. Different array types to include: ¿ Screening, test and validation arrays from AML patients at diagnosis ¿ Paired diagnosis relapse arrays ¿ Paired blood and marrow specimens. ¿ Stem cells Aim 2. Provide support to validate antibodies for specificity for use in RPPA and define optimal conditions for their use in RPPA. Aim 3. Provide custom RPPA arrays for program project investigators to test the effects of: ¿ Stroma and mesenchymal stem cells on protein expression and activation states. ¿ Effect of novel agents, including drugs, RNAi, microRNA etc on protein expression and activation states. Aim 4. Provide HTA arrays for transcriptional profiling. Different array types to include: ¿ Screening, test and validation arrays from AML patients at diagnosis ¿ Paired diagnosis relapse arrays ¿ Paired blood and marrow specimens. Aim 5.Assist with data acquisition and analysis from the arrays.
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