Core B - MYELOMA TISSUE CORE

专注于多发性骨髓瘤的基础、转化和临床科学家必须能够从分子水平上 特征化的细胞系模型系统，特别是临床注释的新鲜和冷冻的原代组织 样本，以测试和验证他们的假设。骨髓瘤组织核心的主要目的是工作 与每个SPORE项目、核心和计划一起，以确保有效采购、存储和分发 实验室和临床组织样本。D.安德森癌症中心。经验证的标准化 为所有活动建立了操作程序，并在 调查员研究护士生物统计学家血液病理学家会提供最佳组织 每份样本的采集、标准化处理、准确分析、安全储存。这些样品 将与获得并保存的相关患者临床和实验室数据相关联， 遵守所有适用的监管准则。该组织芯也将用于新型和稳健的生物标志物 翻译假设的发展和准确测试。该核心有四个具体目标： 具体目标1。开发和维护完整细胞、血清、DNA、RNA和蛋白质的储存库 来源于血浆细胞感染患者的血液、骨髓和其他组织标本， 在M. D.安德森癌症中心。在以下时间采集和处理样本： 诊断、治疗期间、缓解期或复发时。该核心将向孢子分发组织标本 研究者进行分析，同时提供全面的血液病理学特征， 收集和保存参数的注释。Tissue Core还保存了 骨髓瘤细胞系，并将作为一个集中的储存库，用于储存和分发新的 开发细胞系。 具体目标2。维护一个全面的、前瞻性的、交互式的数据库， 浆细胞恶液质患者的病理学数据。 具体目标3。促进SPORE内部和内部的协作，以及与非SPORE的协作 研究者，通过从SPORE获取和分发临床样本资源 调查人员和其他人在M。D.安德森癌症中心，以及与其他国家或 国际来源。这包括开发信息系统并与其他SPORE站点共享信息系统。 具体目标4。为SPORE研究人员提供库存和定制的反相蛋白质阵列。

Basic, translational, and clinical scientists focusing on multiple myeloma must have access to molecularly characterized cell line model systems, and especially to clinically-annotated fresh and frozen primary tissue samples, to test and validate their hypotheses. The main objective ofthe Myeloma Tissue Core is to work with each SPORE Project, Core, and Program to insure efficient procurement, storage, and distribution of laboratory and clinical tissue samples at the M. D. Anderson Cancer Center. Validated standardized operating procedures have been established for all activities, and continuous communication between the investigators, research nurses, biostatisticians. and hematopathologists will provide for optimal tissue collection, standardized processing, accurate analysis, and safe storage of each sample. These samples will be associated with relevant patient clinical and laboratory data obtained and maintained in accordance with all applicable regulatory guidelines. This Tissue Core will also be used for novel and robust biomarker development and accurate testing of translational hypotheses. There are four specific aims for this Core: Specific Aim 1. To develop and maintain a repository of intact cells, serum, DNA, RNA, and protein derived from blood, bone marrow, and other tissue specimens obtained from patients with plasma cell dyscrasias at the M. D. Anderson Cancer Center. Samples are collected and processed at the time of diagnosis, during therapy, in remission, or at relapse. This Core will distribute tissue specimens to SPORE investigators for analysis, while providing comprehensive hematopathologic characterization with detailed annotation of parameters of collection and preservation. The Tissue Core also maintains a collection of myeloma cell lines, and will act as a centralized repository for the storage and distribution of newly developed cell lines. Specific Aim 2. To maintain a comprehensive, prospective, interactive database with detailed clinical and pathologic data for patients with plasma cell dyscrasias. Specific Aim 3. To facilitate inter- and intra-SPORE collaborations, and collaborations with non-SPORE investigators, through acquisition and distribution of clinical sample resources to and from SPORE investigators and others within the M. D. Anderson Cancer Center, as well as with other national or international sources. This includes developing and sharing the informatics systems with other SPORE sites. Specific Aim 4. To provide stock and customized reverse phase protein arrays to SPORE investigators.