Long-Term Follow-up Core

长期跟进核心

基本信息

  • 批准号:
    7240148
  • 负责人:
  • 金额:
    $ 36.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-12-01 至 2011-11-30
  • 项目状态:
    已结题

项目摘要

Core F: Long-Term Follow-Up. This core supports Projects 1- 6 by collecting long-term follow-up data for patients who have had hematopoietic cell transplantation at the Seattle Cancer Care Alliance, University of Washington Medical Center or Children's Hospital and Regional Medical Center under protocols developed at the Fred Hutchinson Cancer Research Center as part of clinical research studies sponsored by this program. The data provided through Core F are required for a variety of critically important purposes by projects in this program: 1) capture of longer-term outcomes, including the occurrence of chronic GVHD, infections, recurrent or progressive malignancy, secondary malignancy and other anticipated late complications, as well as dates of last contact and death for patients enrolled in prospective research trials, 2) capture of similar observational data for patients not enrolled in prospective studies, to be used for retrospective studies, 3) capture of observational data to be used for planning new clinical trials, and 4) capture of survivorship information to identify previously unrecognized late effects. A variety of mechanisms will be used to support these goals. a) We will continue to collect long-term data focused on survival, therapy-related complications, health and health-related quality of life relevant to the clinical research studies sponsored by this grant. These data concern the retrospective cohort of patients currently in follow-up from previous studies and the prospective cohort of patients to be enrolled .in studies described in Projects 1 - 6 of this grant application. For this purpose, a system has been established to track and maintain contact with patients and referring physicians so that data can be collected at specified time points after treatment. b)We will continue to assist investigators in obtaining long-term data specifically needed for individual research projects. c) We will continue to evaluate the methods employed in data collection and database management, identify barriers that interfere with long-term follow-up, and explore new technology to improve the efficiency and reliability of data collection and the validity and utility of the data. Relevance to Public Health: The data generated from this core unit will assist project leaders in the identification of late complications In patients who have had blood or marrow cell transplantation for treatment of leukemia, lymphoma, myeloma and other related disorders. The data will also provide the basis for hypothesis-driven research concerning risk factors for late complications, the mechanisms leading to late complications, and the development of new approaches for preventing and managing late complications among cancer survivors.
核心F:长期随访。该核心通过收集以下方面的长期后续数据来支持项目1- 6: 曾在西雅图癌症护理联盟, 华盛顿医疗中心或儿童医院和区域医疗中心根据制定的协议 在弗雷德·哈钦森癌症研究中心,作为该中心赞助的临床研究的一部分 程序.通过核心F提供的数据用于各种极其重要的目的, 该计划的项目:1)捕获长期结果,包括慢性GVHD的发生, 感染、复发性或进行性恶性肿瘤、继发性恶性肿瘤和其他预期晚期 并发症,以及入组前瞻性研究试验的患者的末次联系和死亡日期, 2)采集未入组前瞻性研究的患者的类似观察性数据,用于 回顾性研究,3)采集用于计划新临床试验的观察性数据,以及4) 捕获生存率信息,以识别以前未识别的晚期效应。各种机制 将用于支持这些目标。 a)我们将继续收集长期数据,重点关注生存率、治疗相关并发症、健康和 与本基金资助的临床研究相关的健康相关生活质量。这些数据 关注既往研究中目前正在随访的患者回顾性队列, 本补助金项目1 - 6中描述的研究中招募的前瞻性患者队列 应用程序.为此目的,建立了一个系统,以跟踪和保持与患者的联系 以及转诊医师,以便在治疗后的特定时间点收集数据。 B)我们将继续协助研究人员获得个人特别需要的长期数据。 研究项目。 c)我们将继续评估数据收集和数据库管理所采用的方法, 确定干扰长期随访的障碍,并探索新技术以改善 数据收集的效率和可靠性以及数据的有效性和实用性。 与公共卫生的相关性:这一核心单位产生的数据将有助于项目领导人 在接受血液或骨髓细胞移植治疗的患者中, 治疗白血病、淋巴瘤、骨髓瘤和其它相关病症。这些数据也将提供基础 对于关于晚期并发症风险因素的假设驱动的研究,导致晚期并发症的机制 并发症,以及预防和管理晚期并发症的新方法的开发 在癌症幸存者中。

项目成果

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PAUL J MARTIN其他文献

PAUL J MARTIN的其他文献

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{{ truncateString('PAUL J MARTIN', 18)}}的其他基金

Protocol Review and Monitoring System
方案审查和监控系统
  • 批准号:
    8804792
  • 财政年份:
    2015
  • 资助金额:
    $ 36.01万
  • 项目类别:
Clinical Protocol and Data Management
临床方案和数据管理
  • 批准号:
    9001923
  • 财政年份:
    2015
  • 资助金额:
    $ 36.01万
  • 项目类别:
Patient Enrollment, Specimen and Data Management, and Biostatistics
患者登记、样本和数据管理以及生物统计学
  • 批准号:
    8309107
  • 财政年份:
    2011
  • 资助金额:
    $ 36.01万
  • 项目类别:
Long-Term Follow-up Core
长期跟进核心
  • 批准号:
    8277828
  • 财政年份:
    2011
  • 资助金额:
    $ 36.01万
  • 项目类别:
Prevention and Treatment of Graft-Versus-Host Disease
移植物抗宿主病的预防和治疗
  • 批准号:
    8277819
  • 财政年份:
    2011
  • 资助金额:
    $ 36.01万
  • 项目类别:
EFFICACY OF CD28 ANTIBODY FOR GVHD PREVENTION
CD28 抗体预防 GVHD 的功效
  • 批准号:
    8172753
  • 财政年份:
    2010
  • 资助金额:
    $ 36.01万
  • 项目类别:
Patient Enrollment, Specimen and Data Management, and Biostatistics
患者登记、样本和数据管理以及生物统计学
  • 批准号:
    7676420
  • 财政年份:
    2009
  • 资助金额:
    $ 36.01万
  • 项目类别:
EFFICACY OF CD28 ANTIBODY FOR GVHD PREVENTION
CD28 抗体预防 GVHD 的功效
  • 批准号:
    7958857
  • 财政年份:
    2009
  • 资助金额:
    $ 36.01万
  • 项目类别:
Core--Long-Term Follow-Up and Chronic GVHD
核心--长期随访与慢性GVHD
  • 批准号:
    7478452
  • 财政年份:
    2007
  • 资助金额:
    $ 36.01万
  • 项目类别:
Core--Long-Term Follow-Up and Chronic GVHD
核心--长期随访与慢性GVHD
  • 批准号:
    7304878
  • 财政年份:
    2006
  • 资助金额:
    $ 36.01万
  • 项目类别:
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