Long-Term Follow-up Core

长期跟进核心

• 批准号: 8277828
• 负责人: PAUL J MARTIN
• 金额: $ 45.83万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8277828
• 关键词: Aftercare; Applications Grants; Blood; Cancer Survivor; Cell Transplantation; Cessation of life; Clinical Research; Clinical Trials; Data; Data Base Management; Data Collection; Development; Disease; Enrollment; Fred Hutchinson Cancer Research Center; Goals; Grant; Health; Hematopoietic; Individual; Infection; Late Effects; Malignant Neoplasms; Marrow; Medical center; Methods; Multiple Myeloma; Outcome; Patients; Pediatric Hospitals; Physicians; Prospective Studies; Protocols documentation; Public Health; Recurrence; Research; Research Personnel; Research Project Grants; Retrospective Studies; Risk Factors; Second Primary Cancers; Specific qualifier value; System; Time; Universities; Washington; adult leukemia; base; cancer care; chronic graft versus host disease; cohort; follow-up; health related quality of life; improved; leukemia/lymphoma; new technology; novel strategies; prevent; programs; prospective; research study; survivorship

Core F: Long-Term Follow-Up. This core supports Projects 1- 6 by collecting long-term follow-up data for patients who have had hematopoietic cell transplantation at the Seattle Cancer Care Alliance, University of Washington Medical Center or Children's Hospital and Regional Medical Center under protocols developed at the Fred Hutchinson Cancer Research Center as part of clinical research studies sponsored by this program. The data provided through Core F are required for a variety of critically important purposes by projects in this program: 1) capture of longer-term outcomes, including the occurrence of chronic GVHD, infections, recurrent or progressive malignancy, secondary malignancy and other anticipated late complications, as well as dates of last contact and death for patients enrolled in prospective research trials, 2) capture of similar observational data for patients not enrolled in prospective studies, to be used for retrospective studies, 3) capture of observational data to be used for planning new clinical trials, and 4) capture of survivorship information to identify previously unrecognized late effects. A variety of mechanisms will be used to support these goals. a) We will continue to collect long-term data focused on survival, therapy-related complications, health and health-related quality of life relevant to the clinical research studies sponsored by this grant. These data concern the retrospective cohort of patients currently in follow-up from previous studies and the prospective cohort of patients to be enrolled .in studies described in Projects 1 - 6 of this grant application. For this purpose, a system has been established to track and maintain contact with patients and referring physicians so that data can be collected at specified time points after treatment. b)We will continue to assist investigators in obtaining long-term data specifically needed for individual research projects. c) We will continue to evaluate the methods employed in data collection and database management, identify barriers that interfere with long-term follow-up, and explore new technology to improve the efficiency and reliability of data collection and the validity and utility of the data. Relevance to Public Health: The data generated from this core unit will assist project leaders in the identification of late complications In patients who have had blood or marrow cell transplantation for treatment of leukemia, lymphoma, myeloma and other related disorders. The data will also provide the basis for hypothesis-driven research concerning risk factors for late complications, the mechanisms leading to late complications, and the development of new approaches for preventing and managing late complications among cancer survivors.

核心F：长期随访。该核心通过收集长期后续数据来支持项目1-6 在西雅图癌症护理联盟（University of University of University of）的西雅图癌症护理联盟中造血细胞移植的患者 华盛顿医疗中心或儿童医院和地区医疗中心根据规程开发了 作为临床研究的一部分，在弗雷德·哈钦森癌症研究中心发起的一部分 程序。通过核心F提供的数据是为了各种至关重要的目的而需要的数据 该计划中的项目：1）捕获长期结局，包括慢性GVHD的发生 感染，反复或进行性恶性肿瘤，继发性恶性肿瘤和其他预期的晚期 并发症以及参加前瞻性研究试验的患者的最后一次接触和死亡日期， 2）捕获未参加前瞻性研究的患者的类似观察数据，用于 回顾性研究，3）捕获用于计划新临床试验的观测数据，4） 捕获生存信息，以识别先前无法识别的后期影响。多种机制 将用于支持这些目标。 a）我们将继续收集有关生存，与治疗相关的并发症，健康和健康的长期数据 与该赠款赞助的临床研究相关的与健康相关的生活质量。这些数据 涉及目前正在研究的患者的回顾性队列和 在该赠款的项目1-6中描述的研究中，要入学的患者的预期队列 应用。为此，已经建立了一个系统来跟踪与患者的接触 并引用医生，以便可以在治疗后的指定时间点收集数据。 b）我们将继续协助调查人员获得专门需要的长期数据 研究项目。 c）我们将继续评估数据收集和数据库管理中使用的方法 确定干扰长期随访的障碍，并探索新技术以改善 数据收集的效率和可靠性以及数据的有效性和实用性。 与公共卫生的相关性：该核心单位产生的数据将帮助项目负责人 鉴定患有血液或骨髓细胞移植的患者的晚期并发症 白血病，淋巴瘤，骨髓瘤和其他相关疾病的治疗。数据还将提供基础 对于假设驱动的有关晚期并发症危险因素的研究，导致晚期的机制 并发症以及预防和管理晚期并发症的新方法的发展 在癌症幸存者中。