Patient Enrollment, Specimen and Data Management, and Biostatistics
患者登记、样本和数据管理以及生物统计学
基本信息
- 批准号:8309107
- 负责人:
- 金额:$ 26.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-08-01 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:AllogenicBiologicalBiometryBloodBlood specimenBone Marrow TransplantationCell TransplantationCellsClinicalDevelopmentDiseaseDonor Lymphocyte InfusionEnrollmentEvaluationFreezingFutureHLA-DR AntigensHematopoieticIL2RA geneIL7R geneImmuneImmunobiologyImmunosuppressionImmunosuppressive AgentsInstructionLeftMalignant NeoplasmsMedical RecordsMonitorOutcomePatientsPharmaceutical PreparationsPhysiciansProcessProviderReactionRecurrenceResearch PersonnelSamplingSpecimenabstractingcancer carechronic graft versus host diseasedata managementgraft vs host diseaseleukemiaprogramsresearch study
项目摘要
Core B: Patient enrollment, specimen and data management, and biostatistics. This core supports
Projects 1 and 2 in four ways. First, the core is responsible for enrolling patients and collecting clinical
information that is needed for Projects 1 and 2. Patients are categorized according to the presence of graft-
versus-host disease (GVHD) activity and immunosuppressive treatment. This information is obtained
primarily by abstracting medical records from providers at the Seattle Cancer Care Alliance and from
referring physicians. Second, the core is responsible for procuring blood samples from selected patients
who have outcomes that are informative for the development of tolerance after hematopoietic cell
transplantation (HCT). For example, samples are routinely obtained from patients when they leave Seattle
at approximately 3 months after HCT and when they return for evaluation at 1 year after HCT. In addition, a
concerted effort is made to collect blood samples before the onset of immunosuppressive treatment in
patients who develop chronic GVHD. Blood samples are also collected from patients before and after
infusion of donor lymphocytes for treatment of recurrent malignancy following HCT. In these patients, blood
samples are also obtained before immunosuppressive medications are given to treat any GVHD that might
occur after donor lymphocyte infusion. These samples are likely to be particularly informative, since donor
lymphocyte infusions are used only in patients who have no GVHD after immunosuppressive medications
have been withdrawn. In these patients, immune reactions can be monitored with no potential interference
from the effects of immunosuppressive medications. Third, the core is responsible for processing blood
samples, enumerating cells that express CDS, CD4, CDS, CD25, CD127 and HLA-DR, and freezing
samples for future use in Projects 1 and 2. Fourth, the core provides support for data management and
biostatistical analysis of results from Projects 1 and 2.
RELEVANCE (See instructions):
Immune reactions of donor cells against the recipient can cause complications when blood or marrow
transplantation is used to treat leukemia and other diseases. The biological mechanisms that control these
harmful immune reactions are not well understood. This core strengthens the overall program by providing
investigators in Projects 1 and 2 with the clinical information and blood specimens needed for research
studies that will help to identify the mechanisms that control these harmful immune reactions.
核心B:患者登记、标本和数据管理以及生物统计学。该核心支持
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('PAUL J MARTIN', 18)}}的其他基金
Prevention and Treatment of Graft-Versus-Host Disease
移植物抗宿主病的预防和治疗
- 批准号:
8277819 - 财政年份:2011
- 资助金额:
$ 26.73万 - 项目类别:
EFFICACY OF CD28 ANTIBODY FOR GVHD PREVENTION
CD28 抗体预防 GVHD 的功效
- 批准号:
8172753 - 财政年份:2010
- 资助金额:
$ 26.73万 - 项目类别:
Patient Enrollment, Specimen and Data Management, and Biostatistics
患者登记、样本和数据管理以及生物统计学
- 批准号:
7676420 - 财政年份:2009
- 资助金额:
$ 26.73万 - 项目类别:
EFFICACY OF CD28 ANTIBODY FOR GVHD PREVENTION
CD28 抗体预防 GVHD 的功效
- 批准号:
7958857 - 财政年份:2009
- 资助金额:
$ 26.73万 - 项目类别:
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